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[ CAS No. 590417-55-3 ]

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Chemical Structure| 590417-55-3
Chemical Structure| 590417-55-3
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Product Details of [ 590417-55-3 ]

CAS No. :590417-55-3 MDL No. :MFCD08435875
Formula : C9H8BrN Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :210.07 g/mol Pubchem ID :-
Synonyms :

Safety of [ 590417-55-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338 UN#:N/A
Hazard Statements:H302-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 590417-55-3 ]

  • Downstream synthetic route of [ 590417-55-3 ]

[ 590417-55-3 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 590417-55-3 ]
  • [ 108-94-1 ]
  • [ 866721-35-9 ]
YieldReaction ConditionsOperation in experiment
73% With palladium diacetate; potassium phosphate; CyJohnPhos In tetrahydrofuran at 100℃; for 48h;
  • 2
  • [ 590417-55-3 ]
  • [ 597540-82-4 ]
  • (10S,11R,14S,15S)-5,13-diaza-14-isopropyl-5-methyl-16-methylene-10-phenyl-13-(2,4,6-trimethylphenylsulfonyl)tetracyclo[7.7.0.02,6.011,15]hexadeca-1(9),2(6),3,7-tetraene [ No CAS ]
  • (10S,11S,14S,15S)-5,13-diaza-14-isopropyl-5-methyl-16-methylene-10-phenyl-13-(2,4,6-trimethylphenylsulfonyl)tetracyclo[7.7.0.02,6.011,15]hexadeca-1(9),2(6),3,7-tetraene [ No CAS ]
YieldReaction ConditionsOperation in experiment
1: 43% 2: 6% With potassium carbonate In 1,4-dioxane for 12h; Heating;
  • 3
  • [ 52488-36-5 ]
  • [ 74-88-4 ]
  • [ 590417-55-3 ]
YieldReaction ConditionsOperation in experiment
100% With sodium hydride In N,N-dimethyl-formamide at 20℃; for 3h;
100% Stage #1: 4-bromo-1H-indole With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Schlenk technique; Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; Schlenk technique;
98% With sodium hydride In tetrahydrofuran at 20℃; for 4h;
97% Stage #1: 4-bromo-1H-indole With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 5h; Inert atmosphere; 4-bromo-1-methyl-1H-indole (15) To a solution of THF (50 mL) was added NaH (263 mg, 6.58 mmol, 1.2 eq.) at rt, to which compound 14 (0.7 mL, 5.48 mmol) was added drop wise and allowed to stir. After 30 min, methyl iodide (0.48 mL, 7.67 mmol, 1.4 eq.) was added and allowed to stir for 5 h. The reaction was quenched with brine and extracted with hexane (x2). The organic layers were combined, washed with water and brine, dried over MgSO4 and concentrated. The crude material was purified by flash silica gel chromatography (1:4 EtOAc:hexane) to afford product in 97% yield.
95% Stage #1: 4-bromo-1H-indole With sodium hydride In 1,2-dimethoxyethane; dimethyl sulfoxide at 20℃; for 0.5h; Stage #2: methyl iodide In 1,2-dimethoxyethane; dimethyl sulfoxide at 20℃;
91% Stage #1: 4-bromo-1H-indole With potassium hydroxide In tetrahydrofuran at 20℃; for 0.25h; Schlenk technique; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran for 6h; Schlenk technique; Inert atmosphere;
73% With potassium <i>tert</i>-butylate In diethyl ether at 0℃; for 24h;
73% With potassium <i>tert</i>-butylate In diethyl ether at 0℃; for 24h;
56% Stage #1: 4-bromo-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 0℃; for 3h; 4-Bromo- 1 -methyl- lH-indole . NaH (1.22 g, 51.02 mmol, 2.0 eq) was added portion wise to a stirred solution of 4-bromo-lH-indole (5.0 g, 25.51 mmol, 1.0 eq) in DMF (100 mL), at 0°C. The mixture was stirred for 30 min, and then CH3I (9.0 g, 63.77 mmol, 2.5 eq) in DMF (20 mL) was added at 0 °C. The reaction mixture was stirred at 0 °C for 3 h. TLC and LC-MS indicated completion, water (50 mL) was added and the mixture was extracted with EtOAc (2 χ 50 mL), dried over sodium sulfate, concentrated and purified by silica column to give 4- bromo-1 -methyl- lH-indole (3.2 g, 56%). NMR (300 MHz, CDCb): 7.31-7.27 (m, 2 H), 7.14-7.12 (m, 2 H), 6.56 (s, 1FL3.82 (s, 3 H). ESI-MS (m/z): 210.0 (M+H)+.
50% Stage #1: 4-bromo-1H-indole With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 3h; 171.1 Step 1: 4-bromo-1-methyl-1H-indole: [00653] To a solution of 4-bromo-1H-indole (2.0 g, 0.01 mol) in DMF (30 mL) was added NaH (0.6 g, 0.015 mol) at 0 °C. The resultant solution was stirred at rt for 30 min, then Mel (1.42 g, 0.01 mol) was added and stirred at for 3 h. The reaction mixture was poured into ice-water and extracted with EtOAc, the organic phase was dried over Na2S04, filtered and concentrated, the crude was purified by SGC to obtain 4-bromo-1-methyl-1H-indole (1.05 g, 50%) as a yellow solid.
48% Stage #1: 4-bromo-1H-indole With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1.75h; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 24h;
Stage #1: 4-bromo-1H-indole With sodium hydride In DMF (N,N-dimethyl-formamide) at 0℃; for 0.166667h; Stage #2: methyl iodide In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 0.666667h; 121 Example 121; Synthesis of 4-bromo-1-methyl-1H-indole (Intermediate 51) Example 121 Synthesis of 4-bromo-1-methyl-1H-indole (Intermediate 51) A solution of 4-bromoindole (5 g, TCI) in DMF (30 ml) was added with 60% sodium hydride (1.14 g) under ice cooling and stirred for 10 minutes.The mixture was added dropwise with methyl iodide (3.18 ml, TCI), stirred for 10 minutes, then warmed to room temperature and further stirred for 30 minutes.The reaction mixture was poured into ice water and added with ethyl acetate (300 ml) for extraction.The organic layer was washed successively with saturated aqueous sodium hydrogencarbonate, saturated aqueous ammonium chloride and saturated brine and dried, and then the solvent was evaporated under reduced pressure.The residue was purified by column chromatography (Quad, hexane:ethyl acetate=10:1) to obtain the title compound (Intermediate 51, 4.95 g).
Stage #1: 4-bromo-1H-indole With sodium hydride In N,N-dimethyl-formamide at -10 - 20℃; for 0.166667h; Stage #2: methyl iodide In N,N-dimethyl-formamide at -10 - 20℃; for 3h; 23 Example 23; Preparation of A44; Synthesis of 4-Bromo-l -methyl- lH-indole, K-56; To a solution of NaH (60% in oil, 600 mg, 15 mmol) in DMF (20 mL), 4-bromoindole (1.96 g, 10 mmol) was added at -10 0C. and stirred at room temperature for 10 min. Iodomethane (6.7 g, 50 mmol) was added at -10 0C. The reaction mixture was stirred at room temperature for 3 h and then diluted with methylene chloride (200 mL). The reaction mixture was washed with water (3 x 200 mL), brine and dried over sodium sulfate. The mixture was filtered and concentrated to give 3 g of K-56 that was used without further purification.
With potassium <i>tert</i>-butylate In diethyl ether at 0℃; for 24h;
Stage #1: 4-bromo-1H-indole With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1.25h; Inert atmosphere; Glovebox; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h;
Stage #1: 4-bromo-1H-indole With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 2h; Inert atmosphere; Stage #2: methyl iodide In dimethyl sulfoxide; mineral oil for 2h; Inert atmosphere;
Stage #1: 4-bromo-1H-indole With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1.25h; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h;
Stage #1: 4-bromo-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere; Cooling; Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 20℃; for 12h; Cooling; Inert atmosphere;
Stage #1: 4-bromo-1H-indole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; Inert atmosphere;

Reference: [1]Location in patent: scheme or table Zhou, Nian; Zeller, Wayne; Zhang, Jun; Onua, Emmanuel; Kiselyov, Alex S.; Ramirez, Jose; Palsdottir, Gudrun; Halldorsdottir, Gudrun; Andresson, Thorkell; Gurney, Mark E.; Singh, Jasbir [Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 5, p. 1528 - 1531]
[2]Zheng, Hong-Xing; Shan, Xiang-Huan; Qu, Jian-Ping; Kang, Yan-Biao [Organic Letters, 2017, vol. 19, # 19, p. 5114 - 5117]
[3]Liu, Haichao; Chen, Lijun; Yuan, Kuo; Jia, Yanxing [Angewandte Chemie - International Edition, 2019, vol. 58, # 19, p. 6362 - 6365][Angew. Chem., 2019, vol. 131, p. 6428 - 6431,4]
[4]Rafferty, Ryan J.; Williams, Robert M. [Tetrahedron Letters, 2011, vol. 52, # 17, p. 2037 - 2040]
[5]Stadlwieser, Josef F.; Dambaur, Markus E. [Helvetica Chimica Acta, 2006, vol. 89, # 5, p. 936 - 946]
[6]Despotopoulou, Christina; McKeon, Sean C.; Connon, Robert; Coeffard, Vincent; Müller-Bunz, Helge; Guiry, Patrick J. [European Journal of Organic Chemistry, 2017, vol. 2017, # 45, p. 6734 - 6738]
[7]Ji, Yuan-Zhao; Li, Hui-Jing; Zhang, Jin-Yu; Wu, Yan-Chao [Chemical Communications, 2019, vol. 55, # 79, p. 11864 - 11867]
[8]Ji, Yuan-Zhao; Li, Hui-Jing; Wang, Yi-Ruo; Wu, Yan-Chao; Zhang, Zheng-Yan [Advanced synthesis and catalysis, 2020]
[9]Current Patent Assignee: SIHUAN PHARMACEUTICAL HOLDINGS GROUP LTD. - WO2019/10295, 2019, A1 Location in patent: Page/Page column 163
[10]Current Patent Assignee: NAVITOR PHARMACEUTICALS - WO2018/191146, 2018, A1 Location in patent: Paragraph 00653
[11]Tolnai, Gergely L.; Székely, Anna; Makó, Zita; Gáti, Tamás; Daru, János; Bihari, Tamás; Stirling, András; Novák, Zoltán [Chemical Communications, 2015, vol. 51, # 21, p. 4488 - 4491]
[12]Current Patent Assignee: ASAHI KASEI CORPORATION - US2004/44258, 2004, A1 Location in patent: Page 77
[13]Current Patent Assignee: AMGEN INC - WO2006/44415, 2006, A2 Location in patent: Page/Page column 87
[14]Xing, Qi; Shi, Lijun; Lang, Rui; Xia, Chungu; Li, Fuwei [Chemical Communications, 2012, vol. 48, # 89, p. 11023 - 11025]
[15]Wang, Qiang; Qi, Zisong; Xie, Fang; Li, Xingwei [Advanced Synthesis and Catalysis, 2015, vol. 357, # 2-3, p. 355 - 360]
[16]Yan, Guobing; Cao, Xihan; Zheng, Wanbin; Ke, Qiumin; Zhang, Jieyu; Huang, Dayun [Organic and Biomolecular Chemistry, 2017, vol. 15, # 28, p. 5904 - 5907]
[17]Shen, Chaoren; Fink, Cornel; Laurenczy, Gabor; Dyson, Paul J.; Wu, Xiao-Feng [Chemical Communications, 2017, vol. 53, # 92, p. 12422 - 12425]
[18]Duan, Shengguo; Zhang, Wan; Hu, Yuntong; Xu, Ze-Feng; Li, Chuan-Ying [Advanced Synthesis and Catalysis, 2020, vol. 362, # 17, p. 3570 - 3575]
[19]Duan, Shengguo; Xue, Bing; Meng, Hui; Ye, Zihang; Xu, Ze-Feng; Li, Chuan-Ying [Chinese Journal of Chemistry, 2021, vol. 39, # 5, p. 1145 - 1152]
  • 4
  • [ 590417-55-3 ]
  • 4,4,5,5-tetramethyl-1,3,2-dioxaborolane [ No CAS ]
  • 1-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole [ No CAS ]
YieldReaction ConditionsOperation in experiment
79% With triethylamine In 1,4-dioxane at 80℃;
  • 5
  • [ 590417-55-3 ]
  • [ 866721-32-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 73 percent / (2-biphenylyl)dicyclohexylphosphine; K3PO4; Pd(OAc)2 / tetrahydrofuran / 48 h / 100 °C 2: 73 percent / POCl3 / 1 h / 20 °C
  • 6
  • [ 590417-55-3 ]
  • C16H17NO [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 73 percent / (2-biphenylyl)dicyclohexylphosphine; K3PO4; Pd(OAc)2 / tetrahydrofuran / 48 h / 100 °C 2: 73 percent / POCl3 / 1 h / 20 °C 3: 92 percent / TsOH; Et3SiH / tetrahydrofuran / 24 h / 50 °C
  • 7
  • [ 590417-55-3 ]
  • C16H15NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 73 percent / (2-biphenylyl)dicyclohexylphosphine; K3PO4; Pd(OAc)2 / tetrahydrofuran / 48 h / 100 °C 2: 73 percent / POCl3 / 1 h / 20 °C 3: 45 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; TsOH / tetrahydrofuran / 24 h / 50 °C
  • 8
  • [ 590417-55-3 ]
  • C16H17NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: 73 percent / (2-biphenylyl)dicyclohexylphosphine; K3PO4; Pd(OAc)2 / tetrahydrofuran / 48 h / 100 °C 2: 73 percent / POCl3 / 1 h / 20 °C 3: 92 percent / TsOH; Et3SiH / tetrahydrofuran / 24 h / 50 °C 4: 52 percent / N-bromosuccinimide / 2-methyl-propan-2-ol / 2 h / 20 °C
  • 9
  • [ 74-88-4 ]
  • [ 590417-55-3 ]
YieldReaction ConditionsOperation in experiment
Stage #1: 4-bromo-1H-indole With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; for 1h; 16 A solution of [4-BROMO-1H-INDOLE] (6.7 g) in tetrahydrofuran (75 [ML)] was treated with sodium hydride (1.24 g) and stirred for 0.5 h at room temperature. The resulting suspension was treated with a solution of iodomethane (2.34 ml) in tetrahydrofuran (35 mi) at [0°C] and allowed to warm to room temperature over 1 h, whilst stirring. The reaction mixture was poured onto water and partitioned between [DICHLOROMETHANE] and water. The organic phase was dried over [(MGS04)] and concentrated in vacuo to afford the title compound (7.2 g). TLC Silica (cyclohexane-ethyl acetate [1: 1] ), Rf = 0.55.
Stage #1: 4-bromo-1H-indole With sodium hydride In N,N-dimethyl-formamide at -10 - 20℃; for 0.166667h; Stage #2: methyl iodide In N,N-dimethyl-formamide at -10 - 20℃; for 3h; 41 Example 41. Preparation of B43.Synthesis of 4-Bromo-l -methyl- lH-indole, 1-32. To a solution of NaH (60% in mineral oil, 600 mg, 15 mmol) in DMF (20 mL), 4-bromo-lH-indole (1.96 g, 10 mmol) was added at -10 0C. The stirring mixture was allowed to warm to rt for 10 min, recooled to -10 0C and then iodomethane (6.7 g, 50 mmol) was added at -10 0C. The reaction mixture was stirred at rt for 3 h and diluted with CH2Cl2 (-200 mL). The reaction mixture was washed with water (3 x 200 mL), brine and dried over sodium sulfate. After filtration and removal of the solvent, 3 g of crude product 1-32 was obtained. This compound was directly used in next step reaction without further purification. 1H-NMR (500 MHz, CDCl3) confirmed the structure.
  • 10
  • [ 590417-55-3 ]
  • [ 407-25-0 ]
  • [ 1448890-62-7 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran at 0 - 20℃; for 6h; 17 A solution of [4-BROMO-1-METHYL-1H-INDOLE] [(D16)] (7.0 g) in tetrahydrofuran (50 [ML)] was treated with a solution of trifluoroacetic anhydride (5.65 ml) in tetrahydrofuran (20 ml) at [0°C.] The reaction mixture was allowed to warm to room temperature over 6 h, whilst stirring. The reaction mixture was concentrated in vacuo and then re-suspended in ethanol (25 [ML).] The solution was treated with 5N sodium hydroxide solution (50 ml) and heated under reflux for 18 h. The reaction mixture was washed with diethyl ether and the aqueous phase acidified with 5N hydrochloric acid solution. The precipitate was filtered, washed with water and concentrated in vacuo to afford the title compound (4.88 g). TLC, Silica (cyclohexane-ethyl acetate-acetic acid [3: 1: 0.1]), Rf = 0.35.
  • 11
  • [ 590417-55-3 ]
  • [ 590417-56-4 ]
YieldReaction ConditionsOperation in experiment
Stage #1: 4-bromo-1-methyl-1H-indole With n-butyllithium In tetrahydrofuran; pentane at -78℃; for 1h; Stage #2: With Triisopropyl borate In tetrahydrofuran; pentane at 20℃; for 4h; 121 Synthesis of 1-methyl-1H-indole-4-boronic Acid (Intermediate 52) Synthesis of 1-methyl-1H-indole-4-boronic Acid (Intermediate 52) A solution of Intermediate 51 (4.90 g) in anhydrous THF (30 ml) was cooled to -78° C. under argon atmosphere, then added dropwise with 1.62 M solution of n-butyllithium in pentane (28.8 ml) over 30 minutes and stirred for 30 minutes.The mixture was added dropwise with (iPrO)3B (10.77 ml) over 10 minutes, stirred for 1 hour, then warmed to room temperature and further stirred for 2.5 hours.The reaction mixture was poured into 1.2 N aqueous phosphoric acid (250 ml) added with ice, and extracted with diethyl ether (200 ml*3).The organic layer was extracted with 0.4 N aqueous sodium hydroxide (150 ml*3), and the aqueous layer was acidified with 5 N aqueous hydrochloric acid under ice cooling and extracted with diethyl ether (200 ml*3) again.The organic layer was washed with saturated brine and dried, and then the solvent was evaporated under reduced pressure.The residue was washed with hexane to obtain the title compound (Intermediate 52, 3.17 g).
  • 12
  • [ 590417-55-3 ]
  • [ 135-19-3 ]
  • [ 885226-02-8 ]
YieldReaction ConditionsOperation in experiment
83% With N,N-dimethylglycine hydrochoride; caesium carbonate In 1,4-dioxane at 105℃; for 48h; 41 Synthesis of l-Methyl-4-(naphthalen-2-yloxy)-lH-indole, 1-33. A mixture of 1-32 (2.4 g, 11.42 mmol), CuI (217 mg, 1.142 mmol), N,N-dimethylglycine HCl salt (480 mg, 3.42 mmol), 2-naphthol (2.47 g, 17.14 mmol) and Cs2CO3 (7.42 g, 22.84 mmol) in dioxane (22 mL) was stirred under Ar at 105 0C for 2 d. The reaction mixture was diluted with ethyl acetate and washed with water, brine and dried over sodium sulfate. After removal of solvent, the residue was purified by column chromatography on silica gel with 2% ethyl acetate/hexane as an eluent to give 2.16 l-Methyl-4-(naρhthalen-2-yloxy)-lH-indole, 1-33 (83% yield) 1H-NMR (500 MHz, CDCl3) confirmed the structure.
With copper(l) iodide; N,N-dimethylglycine hydrochoride; caesium carbonate In 1,4-dioxane at 105℃;
With copper(l) iodide; N,N-dimethylglycine hydrochoride; caesium carbonate In 1,4-dioxane at 105℃; for 72h; 23 General Procedure (P-5); Coupling of 4-bromoindole K-56 with selected phenols, Products K-57x; A mixture of K-56 (420 mg, 2 mmol), CuI (38 mg, 0.2 mmol, 0.1 eq.), N,N-dimethylglycine HCl salt (84 mg, 0.6 mmol, 0.3 eq.), the appropriate phenol (3 mmol, 1.5 eq) and Cs2CO3 (1.3 g, 4 mmol, 2 e.q.) in dioxane (4 mL) was stirred under Ar at 105 0C. for 3 days. The reaction mixture was diluted with ethyl acetate and washed with water, brine and dried over sodium sulfate. After filtration and removal of the solvent, the residue was purified by column chromatography on silica gel with ethyl acetate/hexane as an eluent to give K-57x.
  • 13
  • [ 590417-55-3 ]
  • [ 25015-63-8 ]
  • 1-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole [ No CAS ]
YieldReaction ConditionsOperation in experiment
79% With palladium diacetate; triethylamine In 1,4-dioxane under Ar atm.; Schlenk flask charged with Pd(CH3COO)2 and P(C6H11)2(C6H4C6H5); evapd.; filled (Ar); 1,4-dioxane added; stirred for 30 min at room temp.; Et3N added; soln. of bromoindole in dioxane added; neat pinacolborane added; stirred at 80°C; cooled to room temp.; Celite and activated charcoal added; stirred for 15 min; filtered; solvent removed (vac.); residue diluted (cyclohexane); filtered through a short pad of neutral alumina; purified by column chromy (SiO2, cyclohexane/ethyl acetate);
  • 14
  • [ 590417-55-3 ]
  • [ 580-16-5 ]
  • [ 1057257-51-8 ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; N,N-dimethylglycine hydrochoride; caesium carbonate In 1,4-dioxane at 105℃;
  • 15
  • [ 590417-55-3 ]
  • [ 150-19-6 ]
  • [ 1057257-47-2 ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; N,N-dimethylglycine hydrochoride; caesium carbonate In 1,4-dioxane at 105℃;
  • 16
  • [ 590417-55-3 ]
  • [ 1996-41-4 ]
  • [ 1057257-25-6 ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; N,N-dimethylglycine hydrochoride; caesium carbonate In 1,4-dioxane at 105℃;
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