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Chemical Structure| 59293-11-7 Chemical Structure| 59293-11-7

Structure of 59293-11-7

Chemical Structure| 59293-11-7

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Product Details of [ 59293-11-7 ]

CAS No. :59293-11-7
Formula : C5H10N2O2
M.W : 130.15
SMILES Code : O=C(C1OCCC1)NN
MDL No. :MFCD02193362

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Application In Synthesis of [ 59293-11-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59293-11-7 ]

[ 59293-11-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 16874-34-3 ]
  • [ 59293-11-7 ]
YieldReaction ConditionsOperation in experiment
With hydrazine; In butan-1-ol; for 3h;Heating / reflux; a) (rac.)-(Tetrahydro-furan-2-yl)-acetic acid hydrazide A solution of (rac.)-(tetrahydro-furan-2-yl)-acetic acid ethyl ester (3.84 g, 24 mmol) in n-butanol (24 mL) was treated with hydrazine hydrate (1.4 mL, 29 mmol) and the resulting mixture was then heated under reflux for 3 h. The solvent was evaporated and residual volatile components were azeotropically removed by coevaporation with toluene. Chromatographic purification (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1) afforded the title compound as a viscous, colorless oil (1.1 g, 32%). 1H-NMR (300 MHz, DMSO): delta=1.45 (mc, 1H), 1.70-1.95 (m, 3H), 2.13 (dd, J=6 Hz, J=14 Hz, 1H), 2.24 (dd, J=7 Hz, J=14 Hz, 1H), 3.56 (dd, J=8 Hz, J=14 Hz, 1H), 3.72 (dd, J=7 Hz, J=14 Hz, 1H), 4.05 (mc, 1H), 4.16 (s, 2H), 8.94 (s, 1H).
 

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