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[ CAS No. 59434-19-4 ]

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Chemical Structure| 59434-19-4
Chemical Structure| 59434-19-4
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Product Details of [ 59434-19-4 ]

CAS No. :59434-19-4 MDL No. :MFCD04117950
Formula : C8H7NO2 Boiling Point : 411°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :149.15 g/mol Pubchem ID :12284649
Synonyms :

1. 4-Aminophthalide

Safety of [ 59434-19-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 59434-19-4 ]

  • Upstream synthesis route of [ 59434-19-4 ]
  • Downstream synthetic route of [ 59434-19-4 ]

[ 59434-19-4 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 65399-18-0 ]
  • [ 59434-19-4 ]
YieldReaction ConditionsOperation in experiment
96% With hydrogen In ethyl acetate at 25℃; for 3 h; A suspension of 4-nitroisobenzofuran-1(3H)-one (1.0 g, 5.58 mmol) and 10percent Pd/C (0.1 g) in ethyl acetate (30 mL) was purged in 1 atm hydrogen and stirred at 25° C. for 3 hr. The mixture was filtered, and the filtrate was concentrated to give 4-aminoisobenzofuran-1(3H)-one (0.8 g, yield 96percent) as a off-white solid. MS (ESI) m/z: 150(M+1)+. 1H-NMR (400 MHz, CDCl3) δ 3.82 (s, br 1H), 5.19 (s, 3H), 6.91-6.95 (m, 1H), 7.32-7.36 (m, 2H)
96% With hydrogen In ethyl acetate at 25℃; for 3 h; Example 2B4-Aminoisobenzofuran- 1 (3H)-one[00472] A suspension of 4-nitroisobenzofuran- l(3H)-one (1.0 g, 5.58 mmol) and 10percent Pd/C (0.1 g) in ethyl acetate (30 mL) was purged in latm hydrogen and stirred at 25 °C for 3 hr. The mixture was filtered, and the filtrate was concentrated to give 4-aminoisobenzofuran-l(3H)-one (0.8 g, yield 96percent) as a off- white solid. MS (ESI) m/z: 150(M+1)+. ^-NMR (400 MHz, CDC13) δ 3.82 (s, br 1H), 5.19 (s, 3H), 6.91- 6.95 (m, 1H), 7.32-7.36 (m, 2H).
Reference: [1] Patent: US2010/35883, 2010, A1, . Location in patent: Page/Page column 48
[2] Patent: WO2011/130661, 2011, A1, . Location in patent: Page/Page column 84-85
[3] Journal fuer Praktische Chemie/Chemiker-Zeitung, 1993, vol. 335, # 1, p. 17 - 22
[4] Advanced Synthesis and Catalysis, 2010, vol. 352, # 11-12, p. 1834 - 1840
[5] Chemistry - A European Journal, 2011, vol. 17, # 21, p. 5903 - 5907
[6] Bulletin de la Societe Scientifique de Bretagne, 1951, vol. 26, p. Sonderheft 5, S. 7, 96[7] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1952, vol. 235, p. 962
[8] Green Chemistry, 2012, vol. 14, # 8, p. 2289 - 2293
  • 2
  • [ 641-70-3 ]
  • [ 59434-19-4 ]
Reference: [1] Patent: WO2011/130661, 2011, A1,
  • 3
  • [ 103260-67-9 ]
  • [ 59434-19-4 ]
Reference: [1] Bulletin de la Societe Scientifique de Bretagne, 1951, vol. 26, p. Sonderheft 5, S. 7, 96[2] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1952, vol. 235, p. 962
[3] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1950, vol. 231, p. 912
  • 4
  • [ 6296-53-3 ]
  • [ 59434-19-4 ]
Reference: [1] Bulletin de la Societe Scientifique de Bretagne, 1951, vol. 26, p. Sonderheft 5, S. 7, 96[2] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1952, vol. 235, p. 962
[3] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1950, vol. 231, p. 912
  • 5
  • [ 87-41-2 ]
  • [ 59434-19-4 ]
Reference: [1] Bulletin de la Societe Scientifique de Bretagne, 1951, vol. 26, p. Sonderheft 5, S. 7, 96[2] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1952, vol. 235, p. 962
  • 6
  • [ 59434-19-4 ]
  • [ 102308-43-0 ]
Reference: [1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 5, p. 1941 - 1946
[2] Bulletin de la Societe Scientifique de Bretagne, 1951, vol. 26, p. Sonderheft 5, S. 7, 96[3] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1952, vol. 235, p. 962
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