Alternatived Products of [ 59724-53-7 ]
Product Details of [ 59724-53-7 ]
CAS No. : | 59724-53-7 |
MDL No. : | MFCD02225949 |
Formula : |
C10H15NO3S
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
229.30
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 59724-53-7 ]
Signal Word: | Warning |
Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 |
UN#: | N/A |
Hazard Statements: | H302 |
Packing Group: | N/A |
GHS Pictogram: |
|
Application In Synthesis of [ 59724-53-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 59724-53-7 ]
- 1
-
[ 384-64-5 ]
-
[ 59724-53-7 ]
-
C19H20FNO3S
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
70% |
With lithium hydroxide In dimethyl sulfoxide at 40℃; for 12h; Schlenk technique; chemoselective reaction; |
2.1 Procedure for defluorinative cyclization of (trifluoromethyl)alkenes with amino alcohols
General procedure: In a 25 mL oven-dried Schlenk tube equipped with a magneticstirring bar, amino alcohols 1 (0.2 mmol), (trifluoromethyl)-alkenes 2 (0.4 mmol), t-BuOLi or LiOH(0.8 mmol), and dimethyl sulfoxide (DMSO, 2 mL) werevigorously stirred at 40 °C for 12 h. Then the stirring wasstopped. Add water (15 mL) to the mixture, which wassuccessively extracted with EtOAc (15 mL×3). The combinedorganic phases were dried over anhydrous Na2SO4,filtered and concentrated in vacuo. Further purification byflash column chromatography on silica gel (eluting with petroleum ether/ethyl acetate) provided the product 3 or 4. |
- 2
-
[ 69843-10-3 ]
-
[ 59724-53-7 ]
-
C19H19ClFNO3S
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
90% |
With lithium hydroxide In dimethyl sulfoxide at 40℃; for 12h; Schlenk technique; chemoselective reaction; |
2.1 Procedure for defluorinative cyclization of (trifluoromethyl)alkenes with amino alcohols
General procedure: In a 25 mL oven-dried Schlenk tube equipped with a magneticstirring bar, amino alcohols 1 (0.2 mmol), (trifluoromethyl)-alkenes 2 (0.4 mmol), t-BuOLi or LiOH(0.8 mmol), and dimethyl sulfoxide (DMSO, 2 mL) werevigorously stirred at 40 °C for 12 h. Then the stirring wasstopped. Add water (15 mL) to the mixture, which wassuccessively extracted with EtOAc (15 mL×3). The combinedorganic phases were dried over anhydrous Na2SO4,filtered and concentrated in vacuo. Further purification byflash column chromatography on silica gel (eluting with petroleum ether/ethyl acetate) provided the product 3 or 4. |