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Chemical Structure| 59965-20-7
Chemical Structure| 59965-20-7
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CAS No. :59965-20-7 MDL No. :MFCD27965647
Formula : C10H21Br Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :221.18 Pubchem ID :-
Synonyms :

Safety of [ 59965-20-7 ]

Signal Word: Class:N/A
Precautionary Statements: UN#:N/A
Hazard Statements: Packing Group:N/A

Application In Synthesis of [ 59965-20-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59965-20-7 ]

[ 59965-20-7 ] Synthesis Path-Downstream   1~80

  • 1
  • [ 106-21-8 ]
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YieldReaction ConditionsOperation in experiment
100% With sulfuric acid; hydrogen bromide; In water; at 120 - 125℃; for 3h; EXAMPLE 1 Racemic 1-Bromo-3,7-dimethyloctane (Dihydrocitronellyl Bromide) Concentrated sulfuric acid (17 mL) was added to 48% hydrobromic acid (100 mL) with stirring, and then 3,7-dimethyloctanol (dihydrocitronellol, Aldrich, 67 mL, 100 g) was added to the mixture. The mixture was then heated to 120-125 C., and kept at this temperature for 3 hours. The reaction was cooled, and extracted into heptane (300 mL). The heptane layer was washed with hydrochloric acid, water, sodium bicarbonate solution, dried and concentrated to leave an oil, 81.5 g. This oil was distilled under vacuum at a bath temperature of 120-125 C., to afford the bromide product as an oil, b.p. 85-87 C./10 mmHg, 78.2 g, 100% yield. Mass Spec: m/z 220, 222 (M+).
100% With sulfuric acid; hydrogen bromide; In water; at 120 - 125℃; for 3h; Concentrated sulfuric acid (17 mL) was added to 48% 41 hydrobromic acid (100 mL) with stirring, and then 42 3,7-dimethyloctanol (dihydrocitronellol, Aldrich, 67 mL, 100 g) was added to the mixture. The mixture was then heated to 120-125 C., and kept at this temperature for 3 hrs. The reaction was cooled, and extracted into heptane (300 mL). The heptane layer was washed with hydrochloric acid, water, sodium bicarbonate solution, dried and concentrated to leave an oil, 81.5 g. This oil was distilled under vacuum at a bath temperature of 120-125 C., to afford the bromide product as an 43 oil, b.p. 85-87 C./10 mmHg, 78.2 g, 100% yield. Mass Spec: m/z 220,222 (M+).
95.1% With sulfuric acid; hydrogen bromide; In water; at 100℃; for 16h; 3,7-Dimethyloctan-1-ol (10.0 g, 63.2 mmol) was suspended in 48% aqueous hydrobromic acid solution, concentratedsulfuric acid (0.17 ml) was added dropwise and the mixture was stirred at 100C for 16 hr. The reaction mixturewas allowed to cool to room temperature, extracted with hexane (200 ml), and washed twice with 5% aqueous sodiumhydrogen carbonate solution (100 ml) and once with 20% brine (100 ml). The organic layer was dried over sodiumsulfate, and the solvent in the filtrate was evaporated to give the title compound (13.3 g, 95.1%) as a colorless oil.
95.1% With sulfuric acid; hydrogen bromide; In water; at 100℃; for 16h; (1) Synthesis of 1-bromo-3,7-dimethyloctane 3,7-Dimethyloctan-1-ol (10.0 g, 63.2 mmol) was suspended in 48% aqueous hydrobromic acid solution, concentrated sulfuric acid (0.17 ml) was added dropwise and the mixture was stirred at 100 C. for 16 hr. The reaction mixture was allowed to cool to room temperature, extracted with hexane (200 ml), and washed twice with 5% aqueous sodium hydrogen carbonate solution (100 ml) and once with 20% brine (100 ml). The organic layer was dried over sodium sulfate, and the solvent in the filtrate was evaporated to give the title compound (13.3 g, 95.1%) as a colorless oil.
82.1% With sulfuric acid; hydrogen bromide; (1) Synthesis of 3,7-dimethyl-1-octyl bromide 48% HBr (200 ml) and concentrated sulfuric acid (0.46 ml) were added to 3,7-dimethyl-1-octanol (21.0 g, 157.9 mmol), and the mixture was heated overnight. After allowing to cool to room temperature, and the mixture was extracted with hexane. The organic layer was washed with 5% aqueous sodium hydrogen carbonate solution and saturated brine, dried and concentrated to give the title compound (28.7 g, 82.1%).
With phosphorus tribromide; In hexane; water; Preparation 17 To neat 3,7-dimethyloctanol (5 ml) was added phosphorus tribromide (1.01 ml). The mixture was stirred for 4 hours at 60 C. The reaction mixture was added to a mixture of water and n-hexane. The organic layer was separated and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 3,7-dimethyloctyl bromide (4.40 g). IR (Neat): 2900, 1450 cm-1 NMR (CDCl3, delta): 0.87 (6H, d, J=6.6 Hz), 0.89 (3H, d, J=6.4 Hz), 1.1-1.3 (6H, m), 1.5-1.9 (4H, m), 3.3-3.5 (2H, m)
With sulfuric acid; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; In water; General procedure: The synthesis of pyridine-based calamitic esters 3a-e is given in Scheme 1. Firstly, 4-Bromophenol was alkylated with the corresponding n-alkyl bromide to give 4-alkoxybromobenzene 1a-e[29-32]. 3,7-Dimethyloctyl bromide in racemic and chiral form were prepared from commercially available 3,7-Dimethyl-1-octanol and (S)-(-)-b-citronellol. As described previously [33], (S)-(-)-b-citronellol was firstly reduced by catalytic hydrogenation (H2,Pd/C in MeOH) to obtain (S)-3,7-dimethyl-1-octanol. Then, both alcohols reacted with. conc. aqu. HBr/conc. H2SO4 using tetrabutylammoniumhydrogensulfate (TBAHS) as catalyst to obtain the corresponding 3,7-Dimethyloctyl bromides. Compounds 1a-e were subjected to halogen-lithium exchange reaction by using n-butyllithiumin 2.5M hexane solution, followed by the treatment with B(OCH3)3 and then acidic hydrolysis to obtain 4-alkoxybenzeneboronic acids 2a-e [29,31,34,35]. In the final step,compounds 2a-e reacted with commercially available Methyl 5-bromopyridine-2-carboxylate in 1,2-dimetoxyethane by using Pd(PPh3)4 as catalyst and saturated NaHCO3 solution to yield the target compounds 3a-e.

Reference: [1]Patent: US8471035,2013,B1 .Location in patent: Page/Page column 9; 10
[2]Patent: US2018/273524,2018,A1 .Location in patent: Paragraph 0044
[3]Patent: EP2816053,2014,A1 .Location in patent: Paragraph 0352
[4]Patent: US9371353,2016,B2 .Location in patent: Page/Page column 73; 74; 75
[5]Helvetica Chimica Acta,1981,vol. 64,p. 1158 - 1173
[6]Molecular Crystals and Liquid Crystals (1969-1991),1991,vol. 195,p. 291 - 305
[7]Patent: US2013/267697,2013,A1 .Location in patent: Page/Page column
[8]Tetrahedron Letters,2006,vol. 47,p. 7071 - 7075
[9]Archiv der Pharmazie,2002,vol. 335,p. 535 - 546
[10]Chemical and Pharmaceutical Bulletin,1998,vol. 46,p. 1428 - 1431
[11]Chemische Berichte,1914,vol. 47,p. 2456
[12]Chemische Berichte,1914,vol. 47,p. 2456
[13]Bulletin of the Chemical Society of Japan,1975,vol. 48,p. 2317 - 2322
[14]Chemische Berichte,1923,vol. 56,p. 2272
[15]Journal of Organic Chemistry,1939,vol. 4,p. 340
[16]Bulletin de la Societe Chimique de France,1937,vol. <5>4,p. 750
[17]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1952,vol. 72,p. 731,734
    Chem.Abstr.,1954,p. 2637
[18]Collection of Czechoslovak Chemical Communications,1951,vol. 16/17,p. 278,281
[19]Bulletin de la Societe Chimique de France,1929,vol. <4> 45,p. 165
[20]Tetrahedron,1957,vol. 1,p. 186,192
[21]Journal of Natural Products,2003,vol. 66,p. 34 - 38
[22]Patent: US5376634,1994,A
[23]Journal of Physical Chemistry A,2011,vol. 115,p. 5525 - 5539
[24]Reactive and functional polymers,2015,vol. 86,p. 67 - 79
[25]Nature Chemistry,2016,vol. 8,p. 80 - 89
[26]Patent: US2017/342091,2017,A1 .Location in patent: Paragraph 0339; 0350
[27]Journal of Molecular Structure,2019,vol. 1198
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  • linalool potassium [ No CAS ]
  • 6-Isopropenyl-3,9,13-trimethyl-tetradec-1-en-3-ol [ No CAS ]
  • (Z)-3,7,11,15-Tetramethyl-hexadeca-1,6-dien-3-ol [ No CAS ]
  • (E)-3,7,11,15-Tetramethyl-hexadeca-1,6-dien-3-ol [ No CAS ]
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  • (+/-)-5-(3,7-dimethyloctyl)thiophene [ No CAS ]
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  • [ 1081-34-1 ]
  • 5,5"-bis(3,7-dimethyloctyl)-2,2':5',2"-terthiophene [ No CAS ]
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  • [ 660394-00-3 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In dichloromethane; 2,7-Dichloro-9-(3,7-dimethyl-octyl)-9H-carbazole 2,7-Dichlorocarbazole (synthesised according to the procedure by Leclerc et al: Morin, Jean-Francois; Leclerc, Mario; Macromolecules (2001), 34(14), 4680-4682) (10.7 g, 45.3 mmol) was added to a 50% w/w aqueous solution of potassium hydroxide (75 ml) and Aliquat-336 (0.5 ml). <strong>[59965-20-7]1-Bromo-3,7-dimethyloctan</strong>e (12.0 g, 54.3 mmol) was added dropwise and the reaction mixture was heated at 85 C. for 12 h. After cooling to room temperature, methylene chloride was added. The reaction mixture was transferred to a separation funnel and the organic layer was removed. The aqueous layer was extracted with methylene chloride (3*) and the combined organic layers were dried over magnesium sulfate. After removal of the solvent in vacuo, the crude product was purified by column chromatography (silica gel, hexane) to yield 13.5 g of the product as colorless solid.
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  • C74H128O8 [ No CAS ]
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  • C58H96O8 [ No CAS ]
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  • C62H104O8 [ No CAS ]
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  • [ 205243-39-6 ]
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  • C66H112O8 [ No CAS ]
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  • C70H120O8 [ No CAS ]
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  • [ 500761-23-9 ]
  • C32H49BrO2 [ No CAS ]
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  • 2,3,11,12-tetrakis(4-(3,7-dimethyloctyl)phenyl)imidazo[1,2-f]imidazo[1',2':1,2]quino[4,3-j]phenanthridine [ No CAS ]
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  • [ 916841-14-0 ]
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  • 5-((E)-4,8-Dimethyl-non-1-enyl)-[2,2';5',2'']terthiophene [ No CAS ]
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  • 2,4,6-tris-[3,4-bis-(3,7-dimethyl-octyloxy)-phenylamino]-methylene}-cyclohexane-1,3,5-trione [ No CAS ]
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  • 1,1-difluoro-4,8-dimethylnon-1-ene [ No CAS ]
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  • [ 881744-37-2 ]
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  • 3-(4,8-dimethyl-1-nonyl)pyridine [ No CAS ]
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  • [ 321858-69-9 ]
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  • ethyl 2,2-difluoro-5,9-dimethyldecanoate [ No CAS ]
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  • [ 611185-34-3 ]
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  • 1-(3,7-dimethyl-octyloxy)-4-ethynyl-2-methyl-benzene [ No CAS ]
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  • 4-[4-(3,7-dimethyl-octyloxy)-phenyl]-2-methyl-but-3-yn-2-ol [ No CAS ]
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  • 4-[4-(3,7-dimethyl-octyloxy)-3-methyl-phenyl]-2-methyl-but-3-yn-2-ol [ No CAS ]
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  • (2E,4E)-3,7,11-trimethyl-2,4-dodecadiene [ No CAS ]
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  • 1,1-difluoro-4,8-dimethylnonane [ No CAS ]
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  • (+/-)-3,7-dimethyl-1-octylamine hydrochloride [ No CAS ]
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  • (+/-)-N-(3,7-dimethyloctyl)-N'-phenethylguanidine hydrochloride [ No CAS ]
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  • (+/-)-N-[2-(1-cyclohexenyl)ethyl]-N'-(3,7-dimethyloctyl)guanidine hydrochloride [ No CAS ]
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  • 1,1-difluoro-4,8-dimethyl-1-methylthiononane [ No CAS ]
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  • 1,1,1-trifluoro-4,8-dimethylnonane [ No CAS ]
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  • C60H86O6 [ No CAS ]
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  • [ 336184-06-6 ]
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  • [ 1025917-79-6 ]
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  • methyl (E)-4-{2-[2-(3,7-dimethyloctyloxy)-4-methylphenyl]ethenyl}benzoate [ No CAS ]
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  • [ 261517-61-7 ]
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  • 2-(3,7-Dimethyloctylsulfoyl)-1,4-divinylbenzol [ No CAS ]
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