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Chemical Structure| 6960-22-1 Chemical Structure| 6960-22-1
Chemical Structure| 6960-22-1

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Product Details of 6-Methylnicotinamide

CAS No. :6960-22-1
Formula : C7H8N2O
M.W : 136.15
SMILES Code : C1=CC(=NC=C1C(N)=O)C
MDL No. :MFCD00006342
InChI Key :IJXDURUAYOKSIS-UHFFFAOYSA-N
Pubchem ID :96351

Safety of 6-Methylnicotinamide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 6-Methylnicotinamide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6960-22-1 ]

[ 6960-22-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6960-22-1 ]
  • [ 56622-54-9 ]
YieldReaction ConditionsOperation in experiment
58% With lithium aluminium tetrahydride; In tetrahydrofuran; at 60℃; for 24.75h; Example 4: Synthesis of 106Step 1 :3.00 g (22.0 mmol) 6-methylnicotinamide is dissolved in 10 ml THF under argon-atmosphere and 34 ml (34 mmol; 1.5 eq.) 1 M lithium aluminum hydride in THF are added. After 45 min additional lithium aluminum hydride (1.22 g; 1.5 eq.) in 40 ml THF is added. The reaction mixture is heated to 60C for 24 h under stirring. The reaction mixture is carefully quenched under stirring with isopropyl alcohol, methanol and finally water at 0C. The solvent is removed under vacuum. After addition of 100 ml 2N NaOH solution and 100 ml DCM the white precipitate is centrifuged off and the aqueous layer is extracted 4 times with 60 ml DCM. The combined organic layers are dried over magnesium sulphate and the solvent is removed under reduced pressure yielding 1.57 g (12.9 mmol; 58%) of the amine 2 which is used without further purification for subsequent reaction steps.
 

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