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[ CAS No. 6004-21-3 ] {[proInfo.proName]}

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Chemical Structure| 6004-21-3
Chemical Structure| 6004-21-3
Structure of 6004-21-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 6004-21-3 ]

CAS No. :6004-21-3 MDL No. :MFCD00018436
Formula : C13H10ClNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 231.68 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 6004-21-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6004-21-3 ]

[ 6004-21-3 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 265659-62-9 ]
  • [ 6004-21-3 ]
  • [ 6167-08-4 ]
YieldReaction ConditionsOperation in experiment
(i) NaH, (ii) /BRN= 1755651/; Multistep reaction;
  • 2
  • [ 6004-21-3 ]
  • [ 75032-86-9 ]
  • [ 6064-03-5 ]
YieldReaction ConditionsOperation in experiment
(i) NaH, (ii) /BRN= 6287836/; Multistep reaction;
  • 3
  • [ 625-99-0 ]
  • [ 55-21-0 ]
  • [ 6004-21-3 ]
YieldReaction ConditionsOperation in experiment
72% With potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 110℃; for 48h;Schlenk technique; Inert atmosphere; General procedure: An oven-dried Schlenk tube was charged with benzamide 1 (0.5 mmol), K2CO3 (207 mg, 1.5 mmol) and aryl iodide 2 (1.0 mol). The tube was evacuated and backfilled with N2 (3 ×), and then DMEDA (0.2 mmol) and anhyd toluene (5.0 mL) were added. The reaction mixture was stirred at 110 C for 48 h. H2O was added and the crude product was extracted with EtOAc. The combined organic phases were washed with brine and H2O, dried (Na2SO4), and concentrated under reduced pressure. The product was purified by silica gel chromatographyto give the desired N-arylated benzamides (Table 2).
  • 4
  • [ 1016-78-0 ]
  • [ 6004-21-3 ]
  • [ 6832-92-4 ]
YieldReaction ConditionsOperation in experiment
85% With formic acid; hydroxylamine hydrochloride; silica gel; at 80℃; for 3h; General procedure: A mixture of 10 mmol of ketone 1-10, 30 mmol of hydroxylamine hydrochloride, 1 g of silica gel in 8 mL of formic acid was heated at 80 while stirring (TLC monitoring) for the time indicated in the table. Silica gel was filtered from the reaction mixture, the filtrate was diluted with 150 mL of water and neutralized with 20% solution of NaOH. The separated precipitate of amides 11, 12a, 12b-16a, 16b, and 18a was filtered off, washed with water on the filter, and dried. Amides 17a, 17b, 19a, 19b, and 20 were extracted from the water solution with toluene (3 × 20 mL), the extract was dried with Na2SO4 and evaporated on a rotary evaporator. The prevailing amide isomer obtained from ketones 2-6 was isolated by recrystallization from 2-propanol. Amides 17, 17b and 19, 19b were analyzed as mixtures.
  • 5
  • [ 94-97-3 ]
  • [ 93-97-0 ]
  • [ 6004-21-3 ]
  • [ 2866-82-2 ]
  • 6
  • [ 6004-21-3 ]
  • [ 57039-63-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: thionyl chloride / 4 h / 80 °C 2.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 2 h / Reflux 2.2: 0 - 20 °C 3.1: bis(1,5-cyclooctadiene)diiridium(I) dichloride / toluene; N,N-dimethyl-formamide / 0.75 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube
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