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[ CAS No. 601517-02-6 ] {[proInfo.proName]}

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Chemical Structure| 601517-02-6
Chemical Structure| 601517-02-6
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Product Details of [ 601517-02-6 ]

CAS No. :601517-02-6 MDL No. :MFCD20720775
Formula : C8H7FN2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 166.15 Pubchem ID :-
Synonyms :

Safety of [ 601517-02-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 601517-02-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 601517-02-6 ]
  • Downstream synthetic route of [ 601517-02-6 ]

[ 601517-02-6 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 601517-02-6 ]
  • [ 64-18-6 ]
  • [ 944742-29-4 ]
YieldReaction ConditionsOperation in experiment
0.8 g at 100℃; for 1 h; To a mixture of formic acid (11.43 mL, 298 mmol) and sulfuric acid (0.866 mL, 16.25 mmol) was added 2-amino-6-fluoro-4-methoxybenzonitrile (0.9 g, 5.42 mmol) in portions. The reaction mixture was stirred at 100° C. for 1 hour, cooled to ambient temperature, and poured into 80 mL of an ice-water mixture. The resulting precipitate was collected by vacuum filtration and dried in vacuo to provide the title intermediate (0.8 g, 4.12 mmol) as an off-white solid. LC/MS (ESI+) m/z=195 (M+H)
0.8 g at 100℃; for 1 h; To a mixture of formic acid (11.43 mL, 298 mmol) and sulfuric acid (0.866 mL, 16.25 mmol) was added 2-amino-6-fluoro-4-methoxybenzonitrile (0.9 g, 5.42 mmol) in portions. The reaction mixture was stirred at 100 °C for 1 hour, cooled to ambient temperature, and poured into 80 mL of an ice-water mixture. The resulting precipitate was collected by vacuum filtration and dried in vacuo to provide the title intermediate (0.8 g, 4.12 mmol) as an off-white solid. LC/MS (ESI+) m/z = 195 (M+H)+
0.8 g at 100℃; for 1 h; To a mixture of formic acid (11.43 mL, 298 mmol) and sulfuric acid (0.866 mL, 16.25 mmol) was added 2-amino-6-fluoro-4-methoxybenzonitrile (0.9 g, 5.42 mmol) in portions. The reaction mixture was stirred at 100° C. for 1 hour, cooled to ambient temperature, and poured into 80 mL of an ice-water mixture. The resulting precipitate was collected by vacuum filtration and dried in vacuo to provide the title intermediate (0.8 g, 4.12 mmol) as an off-white solid. LC/MS (ESI+) m/z=195 (M+H).
0.8 g at 100℃; for 1 h; To a mixture of formic acid (11.43 mL, 298 mmol) and sulfuric acid (0.87 mL, 16.25 mmol) was added 2-amino-6- fluoro-4-methoxybenzonitrile (0.9 g, 5.42 mmol) in portions. The reaction mixture was stirred at 100 °C for 1 h, cooled to RT, and poured into 80 mL of an ice-water mixture. The resulting precipitate was collected by vacuum filtration and dried in vacuo to provide the title intermediate (0.8 g, 4.12 mmol) as an off-white solid. LC/MS (ESI+) m/z = 195 (M+H) +.

Reference: [1] Patent: US2014/213581, 2014, A1, . Location in patent: Paragraph 0635
[2] Patent: WO2014/138484, 2014, A1, . Location in patent: Page/Page column 146
[3] Patent: US2015/38497, 2015, A1, . Location in patent: Paragraph 0799
[4] Patent: WO2016/22724, 2016, A1, . Location in patent: Page/Page column 319
  • 2
  • [ 601517-02-6 ]
  • [ 944742-29-4 ]
Reference: [1] Patent: US2014/107109, 2014, A1, . Location in patent: Page/Page column
[2] Patent: US2014/249104, 2014, A1, . Location in patent: Page/Page column
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