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Chemical Structure| 60166-91-8 Chemical Structure| 60166-91-8

Structure of 60166-91-8

Chemical Structure| 60166-91-8

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Product Details of [ 60166-91-8 ]

CAS No. :60166-91-8
Formula : C13H8Cl2I3NO5
M.W : 709.83
SMILES Code : CC(O[C@@H](C)C(NC1=C(C(C(Cl)=O)=C(C(C(Cl)=O)=C1I)I)I)=O)=O

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Application In Synthesis of [ 60166-91-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 60166-91-8 ]

[ 60166-91-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 60166-91-8 ]
  • [ 534-03-2 ]
  • [ 60166-93-0 ]
YieldReaction ConditionsOperation in experiment
94% In ISOPROPYLAMIDE; at 8 - 20℃; for 10h; 680 g of S-(-)-5-((2-acetyloxy)-1-oxopropyl)amino)-2,4,6-triiodo-1,3-benzendicarboxylic acid dichloride (prepared as described in WO 96/37460) are dissolved in 1360 g of dimethylacetamide at room temperature and after cooling at 15C [Solution A ]. 181 g of 2-ammino-1,3-propanediol purified with the method described in the previous Example 1 are dissolved in 1360 g of dimethylacetamide and added to the solution A in one hour at 8-15C whilst stirring. The reaction is completed after ten hours at room temperature. The reaction mixture is concentrated at 100C at 10 mbar until 98% of the solvent is distilled. 1700 g of water are added to the residue and the solution is purified using the method described in WO 97/30735.Yield on dry Iopamidol: 94% Contents of by-products determined with HPLC method (according to the method described in USP XXIII-NF, 1996, Vsuppl.) = 0.11% The by-product N-[2-hydroxy-1-(hydroxymethyl)ethyl]-- N'-(2,3-dihydroxypropyl)-5-(2-hydroxy-1-oxopropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide, coming from isoserinol, is under the detection limit. No presence of other by-products derived from 3-amino-1,2-propanediol are detected (see as ref. Pharmeuropa, 6, 343-345, 19949.
  • 2
  • [ 60166-91-8 ]
  • [ 60166-93-0 ]
 

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