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Chemical Structure| 6021-21-2 Chemical Structure| 6021-21-2

Structure of 6021-21-2

Chemical Structure| 6021-21-2

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Product Details of [ 6021-21-2 ]

CAS No. :6021-21-2
Formula : C16H13Cl2NO2
M.W : 322.19
SMILES Code : O=C(N(C1=CC=C(Cl)C=C1C(C2=CC=CC=C2)=O)C)CCl
MDL No. :MFCD00127917

Safety of [ 6021-21-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 6021-21-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6021-21-2 ]

[ 6021-21-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 79-04-9 ]
  • [ 1022-13-5 ]
  • [ 6021-21-2 ]
YieldReaction ConditionsOperation in experiment
99% In 2-methyltetrahydrofuran; dichloromethane; at 90℃; under 5171.62 Torr;Flow reactor; Reactor Set-Up: A 25 mL solution of <strong>[1022-13-5]5-chloro-2-(methylamino)benzophenone</strong> (6.14 g, 1 M) in 2-MeTHF was prepared and placed in a 20 mL stainless steel syringe for Syringe Pump A. Neatchloroacetyl chloride was placed in a 8 mL stainless steel syringe for Syringe Pump B, and CH2Cl2was placed in a 20 mL stainless steel syringe for for Syringe Pump C. Reactors were constructedusing 0.04? ID tubing. Reactor I was heated in an oil bath set to the appropriate temperature. ABPR was placed on the system exit and set to 100 psi was installed at the end of the reactor.Procedure: Flow rates for Pump A and Pump C were set to 0.15 mL/min, and Pump B wasset between 0.012 to 0.015 mL/min. The system was equilibrated for 20 min prior to samplecollection for 10 min in a vial containing 1 mL of saturated NaHCO3 as a quench. The resultingorganic solution collected was separated from the aqueous quench and dried with Na2SO4. The product was purified by automated flash chromatography (Rf = 0.17 in 20percent EtOAc/hexanes) toyield amide 5 as a white solid.
 

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Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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