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Chemical Structure| 60331-03-5 Chemical Structure| 60331-03-5

Structure of 60331-03-5

Chemical Structure| 60331-03-5

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Product Details of [ 60331-03-5 ]

CAS No. :60331-03-5
Formula : C6H6ClN3O4
M.W : 219.58
SMILES Code : O=[N+](C1=C(OC)N=C(OC)N=C1Cl)[O-]

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Application In Synthesis of [ 60331-03-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 60331-03-5 ]

[ 60331-03-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21911-84-2 ]
  • [ 60331-03-5 ]
  • [ 1398113-56-8 ]
YieldReaction ConditionsOperation in experiment
78% In tert-butyl alcohol; for 8h;Reflux; General procedure: 4-chloro-2,6-dimethoxy-5-nitropyrimidine (2) (1.43g, 6.5mmol) and appropriate methyl 3-aminopropanoate (6.5mmol) were dissolved in 25mL t-BuOH. The reaction mixture was stirred under reflux for 8h and monitored by TLC. Then the reaction mixture was concentrated in vacuo, diluted with ethyl acetate, washed with brine. The organic phase was dried over anhydrous Na2SO4, and concentrated in vacuo to yield the crude products. Purification by column chromatography provided the desired pure products 3 in good yields.
 

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