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Chemical Structure| 6051-53-2 Chemical Structure| 6051-53-2

Structure of 6051-53-2

Chemical Structure| 6051-53-2

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Product Details of [ 6051-53-2 ]

CAS No. :6051-53-2
Formula : C10H10O2
M.W : 162.19
SMILES Code : CC(C=CC1=CC=CC=C1O)=O

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Application In Synthesis of [ 6051-53-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6051-53-2 ]

[ 6051-53-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 58421-80-0 ]
  • [ 6051-53-2 ]
  • [ 1442476-82-5 ]
YieldReaction ConditionsOperation in experiment
78.5% With potassium carbonate; In acetonitrile; at 30 - 50℃; for 8h;Inert atmosphere; General procedure: A 100mL oven-dried round bottom flask charged with 1.62g (10.0mmol) (E)-4-(2-hydroxy-phenyl)-3-butylene-2-one or 4-(4-hydroxy-phenyl)-3-butylene-2-one, 1.65g (10.0mmol) 4-chloroquinazoline, and 3g potassium carbonate in dry acetonitrile (20mL) was placed at room temperature. The reaction mixture was stirred further for 8h at 30 to 50C. In the reaction mixture, the excess K2CO3 was filtered out, and the solvent was removed by evaporation. The crude product was recrystallized with anhydrous ethanol solvent to yield 75% to 86% of intermediates 4a to 4f. The data for 4a to 4f are shown below.
 

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