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Chemical Structure| 60524-00-7 Chemical Structure| 60524-00-7

Structure of 60524-00-7

Chemical Structure| 60524-00-7

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Product Details of [ 60524-00-7 ]

CAS No. :60524-00-7
Formula : C14H18N2O2
M.W : 246.31
SMILES Code : C(C)(C)(C)OC(NCC1=C[NH]C2=CC=CC=C12)=O
MDL No. :MFCD12405320
InChI Key :VEHKDBGCOVLARX-UHFFFAOYSA-N
Pubchem ID :12504746

Safety of [ 60524-00-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H317
Precautionary Statements:P280

Application In Synthesis of [ 60524-00-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 60524-00-7 ]

[ 60524-00-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 22259-53-6 ]
  • [ 60524-00-7 ]
YieldReaction ConditionsOperation in experiment
46% With dmap; triethylamine; In tetrahydrofuran; dichloromethane; at 20℃; for 2h; To a 500 mL four-neck flask were added <strong>[22259-53-6]3-aminomethylindole</strong> (21 g, 144 mmol), DCM (200 mL), TEA (29 g, 288 mmol) and DMAP (3.5 g, 29 mmol). Boc2O (35.5 g, 158 mmol) in THF was added dropwise and the mixture was stirred at RT for 2 h. After completion, the mixture was washed with water (100 mL x 2), dried over sodium sulfate, concentrated and purified by column chromatography to give 3-(N-t-butoxycarbonylaminomethyl)indole (15.9 g, 46%). 1H NMR (300 MHz, DMSO-d6) = 10.87 (br, 1 H), 7.59 (s, 1 H), 7.34 (s, 1 H), 7.18-6.99 (m, 4 H), 4.26 (s, 2 H), 1.39 (s, 9 H).
 

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