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Chemical Structure| 60710-39-6 Chemical Structure| 60710-39-6

Structure of 60710-39-6

Chemical Structure| 60710-39-6

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Product Details of [ 60710-39-6 ]

CAS No. :60710-39-6
Formula : C7H7BrO
M.W : 187.03
SMILES Code : BrC1=C(C=CC(=C1)O)C
MDL No. :MFCD08273793
InChI Key :GMZKNRDHSHYMHG-UHFFFAOYSA-N
Pubchem ID :10307913

Safety of [ 60710-39-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302+H312+H332-H315-H319-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 60710-39-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 60710-39-6 ]
  • Downstream synthetic route of [ 60710-39-6 ]

[ 60710-39-6 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 60710-39-6 ]
  • [ 73502-04-2 ]
References: [1] Journal of the Chemical Society. Perkin Transactions 2, 2000, # 2, p. 311 - 315.
  • 2
  • [ 60710-39-6 ]
  • [ 18162-48-6 ]
  • [ 164513-48-8 ]
YieldReaction ConditionsOperation in experiment
78% With triethylamine In dichloromethane at 20℃; Cooling with ice Intermediate 71{(S)-6-[(R)-4-(5-Hvdroxy-2-methyl-phenyl)-indan-1 -yloxy1-2,3-dihydro-benzofuran-3- yl)-acetic acid methyl esterStep 1 : (3-bromo-4-methyl-phenoxy)-tert-butyl-dimethyl-silane tert-Butyldimethylsilyl chloride (0.18 g) is added to a solution of 3-bromo-4-methyl- phenol (0.20 g) and triethylamine (0.23 ml_) in dichloromethane (3 ml_) chilled in an ice bath. 4-Dimethylaminopyridine (13 mg) is added and the solution is stirred at room temperature overnight. Dichloromethane is added and the solution is washed with 1 M hydrochloric acid, aqueous NaHC03 solution, and brine, and dried (MgS04). The solvent is evaporated and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate) to give the title compound. Yield: 0.25 g (78percent of theory); LC (method 1 ): tR = 1 .59 min.
78% With dmap; triethylamine In dichloromethane at 20℃; Cooling with ice Intermediate 71{(S)-6-[(R)-4-(5-Hydroxy-2-methyl-phenyl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester Step 1: (3-bromo-4-methyl-phenoxy)-tert-butyl-dimethyl-silanetert-Butyldimethylsilyl chloride (0.18 g) is added to a solution of 3-bromo-4-methyl-phenol (0.20 g) and triethylamine (0.23 mL) in dichloromethane (3 mL) chilled in an ice bath. 4-Dimethylaminopyridine (13 mg) is added and the solution is stirred at room temperature overnight. Dichloromethane is added and the solution is washed with 1 M hydrochloric acid, aqueous NaHCO3 solution, and brine, and dried (MgSO4).The solvent is evaporated and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate) to give the title compound. Yield: 0.25 g (78percent of theory); LC (method 1): tR=1.59 min.
References: [1] Patent: WO2012/72691, 2012, A1, . Location in patent: Page/Page column 107-108.
[2] Patent: US2012/302566, 2012, A1, . Location in patent: Page/Page column 48.
[3] Organic Letters, 2012, vol. 14, # 9, p. 2350 - 2353.
 

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