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[ CAS No. 607373-84-2 ] {[proInfo.proName]}

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Chemical Structure| 607373-84-2
Chemical Structure| 607373-84-2
Structure of 607373-84-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 607373-84-2 ]

CAS No. :607373-84-2 MDL No. :MFCD09907962
Formula : C7H8N2O4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 184.15 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 607373-84-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 607373-84-2 ]

[ 607373-84-2 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 607373-82-0 ]
  • [ 124-41-4 ]
  • [ 607373-84-2 ]
  • 2
  • [ 31872-62-5 ]
  • [ 607373-84-2 ]
  • 3
  • [ 607373-84-2 ]
  • [ 89943-34-0 ]
YieldReaction ConditionsOperation in experiment
99% With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; under 1500.15 Torr; for 7.0h; To a QianCap glass reactor (1850 mL) equipped with magnetic stirrer was added C-7B2 (40 g, 217 mmol) followed by THF (500 mL). Next, 10% palladium on carbon (1.5 g) was added in one portion and the reactor was connected to the source of the hydrogen. Hydrogen pressure was set at 2 bar and reaction was well stirred for 7 h under continuous flow of hydrogen. After that time, UPLCMS analysis showed complete conversion of starting material. The reaction mixture was filtered through the Cellite pad and the filtrate was concentrated in vacuo. As a result, amine C-7B was obtained as a brown solid (33g, 99% yield).
  • 4
  • [ 67-56-1 ]
  • [ 4487-56-3 ]
  • [ 607373-84-2 ]
YieldReaction ConditionsOperation in experiment
98% With sodium; at 0 - 40℃; for 4.16h;Inert atmosphere; To a 2 L three-neck round-bottom flask, containing thermometer, water condenser, connection to inert gas source (argon) and mechanical stirrer, was added methanol (900 mL, HPLC grade) and under argon atmosphere small pieces of sodium (26.7g, 1.16 mol, 2.1 eq) were slowly added for around 1 h with well stirring (CAUTION: reaction is exothermic, but the reaction mixture was not cooled; usually another sodium piece was added when first was consumed). After dissolving the whole portion of sodium, reaction mixture was cooled to -5 C and freshly prepared suspension of the compound C-7B1 (106.25 g, 0.55 mol, 1 eq) in methanol (100 mL, HPLC grade) was carefully added (around 30 minutes) in small portions with well stirring (CAUTION: reaction is highly exothermic, one should avoid exceeding +10 C during the addition). After the whole amount of the substrate C-7B1 suspension was added, reaction mixture was maintained at 0 - 5 C for around 40 min and then it was warmed to room temperature and stirred at 40 C for 3.5 h. After that time, UPLCMS analysis showed complete consumption of the substrate. Then, the reaction mixture was cooled below 10 C and the solid product was filteredand washed with a small amount (50 mL) of cold methanol, water (100 mL), n-hexane (100 mL) and dried on air overnight. In result, 99.3 g of the compound C-7B2 was obtained as a light yellow solid (98 % yield, 97 % purity according to UPLCMS analysis).
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