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Chemical Structure| 607383-80-2 Chemical Structure| 607383-80-2

Structure of 607383-80-2

Chemical Structure| 607383-80-2

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Product Details of [ 607383-80-2 ]

CAS No. :607383-80-2
Formula : C10H14N2O2
M.W : 194.23
SMILES Code : C[C@H](N)C(NC1=CC=C(CO)C=C1)=O

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Application In Synthesis of [ 607383-80-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 607383-80-2 ]

[ 607383-80-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 607383-80-2 ]
  • [ 96-81-1 ]
  • C17H25N3O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0℃; for 18h; (S)-(9H-fluoren-9-yl)methyl l-(4-(hydroxymethyl)phenylamino)-l-oxopropan-2- ylcarbamate (6 g, 14.41 mmol) was dissolved in DMF (25 ml), piperidine (9.81 g, 115 mmol) added and stirred for 1 hr. The mixture was concentrated and coevaporated with toluene. The crude product (solid) was stirred in ether (150 ml) for 1 hr and filtered. This procedure was repeated once and the obtained solid product was dried on high vacuum to yield deprotected compound 66 (2.4 g, 12.36 mmol, 86%) as a white solid and used directly in the next step.A solution of compound 65 (224 mg, 1.55 mmol, 1 eq.) and deprotected compound 66 (300 mg, 1.55 mmol, 1 eq.) in DMF (5 ml) was cooled to 0C in an ice bath and ED AC (474 mg, 2.47 mmol, 1.6 eq.), HOBt (284 mg, 1.85 mmol, 1.2 eq.) and DIPEA (1.35 ml, 7.72 mmol, 5 eq.) were added. The resulting mixture was stirred for 18 hrs allowing it to warm to RT. The crude mixture concentrated in vacuo and purified by silica gel column chromatography (DCM/MeOH, 1:0 to 9: 1, v/v) to yield compound 67 in quantitative yield.MS (ESI) m z; calculated: 336.19 [M+H]+, found: 336.36 [M+H]+
 

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