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Chemical Structure| 61109-48-6 Chemical Structure| 61109-48-6

Structure of 61109-48-6

Chemical Structure| 61109-48-6

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Product Details of [ 61109-48-6 ]

CAS No. :61109-48-6
Formula : C13H12O3
M.W : 216.23
SMILES Code : O=C(OC)C1=C2C=CC(OC)=CC2=CC=C1

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Application In Synthesis of [ 61109-48-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 61109-48-6 ]

[ 61109-48-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 67-56-1 ]
  • [ 36112-61-5 ]
  • [ 61109-48-6 ]
YieldReaction ConditionsOperation in experiment
208 g (96%, based on 6-hydroxy-1-naphthoic acid employed) 208 g (96%, based on 6-hydroxy-1-naphthoic acid employed) (the total yield of methyl 6-methoxy-1-naphthoate and 6-methoxy-1-naphthoic acid, based on the mixture of 6-hydroxy- and 6-methoxy-1-naphthoic acid employed, is 98%) Pure substance content: >99% (GC) Melting point: 44 C.
  • 3
  • [ 61109-48-6 ]
  • [ 36112-61-5 ]
YieldReaction ConditionsOperation in experiment
95% With potassium hydroxide; In tetrahydrofuran; water; at 100℃; for 4h; Method D: to a solution of compound 8a (1.70 g, 7.87 mmol) inTHF (6 mL) was added a 85% aqueous potassium hydroxide solution(3 mL). The mixture was stirred at 100 C for 4 h, cooled to roomtemperature, and acidified with a 1 M HCl solution. The resultingprecipitate was filtered and washed with water to afford thedesired acid 9a (1.51 g, 95%) as a-pink solid.Mp 95.3 C. 1H NMR (300 MHz, DMSO-d6) d 8.77 (d, 1H,J 9.3 Hz, H8), 8.04 (dd, 1H, J 8.1, 1.2 Hz, H2), 7.97 (dd, 1H, J 8.4,1.2 Hz, H4), 7.53 (dd, 1H, J 8.4, 8.1 Hz, H3), 7.42 (d, 1H, J 2.7 Hz,H5), 7.28 (dd, 1H, J 9.3, 2.7 Hz, H7), 3.89 (s, 3H, CH3). 13C NMR(75 MHz, DMSO-d6) d 168.8, 157.1, 135.2, 131.9, 127.7, 127.5, 127.2,126.1, 125.5, 120.0, 106.7, 55.3.
 

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