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Chemical Structure| 613-11-6 Chemical Structure| 613-11-6

Structure of Hydromethylthionine
CAS No.: 613-11-6

Chemical Structure| 613-11-6

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Synonyms: Leukomethylene blue

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Product Details of [ 613-11-6 ]

CAS No. :613-11-6
Formula : C16H19N3S
M.W : 285.41
SMILES Code : CN(C)C1=CC(SC2=CC(N(C)C)=CC=C2N3)=C3C=C1
Synonyms :
Leukomethylene blue
MDL No. :MFCD09029488

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Application In Synthesis of [ 613-11-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 613-11-6 ]

[ 613-11-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 32315-10-9 ]
  • [ 613-11-6 ]
  • [ 302348-51-2 ]
  • 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl 3,7-bis(dimethyl amino)-10H-phenothiazine-10-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Methylene blue (374 mg, 1 mmol), 10 ml of LDCM and 10 mL of water were added to a 50 mL round bottom flask under argon and stirred well. Na2S2O4 (525 mg, 1.5 mmol) and NaHCO3 (168 mg, 2 mmol) were slowly added to the mixture.The mixture was then stirred for 20 minutes until the aqueous phase turned yellow.The aqueous layer was extracted with dichloromethane (2×5 mL) and organic layer was separated.Combine the organic phase,It was dried over anhydrous sodium sulfate.The dried organic phase was quickly poured into a round bottom flask containing triethylamine (TEA, 170 uL, 1.2 mmol) under argon.1mL DCM containing triphosgene (TPG, 120mg, 0.32mmol)Slowly added to the reaction mixture.After the completion of the dropwise addition, the reaction was stirred at room temperature for additional 0.5 hours.4-Hydroxymethylphenylboronic acid (234 mg, 1.0 mmol) and triethylamine (140 muL, 1.0 mmol) were added to the solution, and the mixture was evaporated.The crude product was extracted with EtOAc (3×20 mL) andEtOAc. The crude product was purified by flash column chromatography (EtOAc /EtOAcEtOAcRecrystallization from acetonitrile gave the product as a yellow solid (53.8 g, 10%).
 

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[ 613-11-6 ]

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A1362543 [951131-15-0]

N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dihydrobromide

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