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Chemical Structure| 620630-82-2 Chemical Structure| 620630-82-2

Structure of 620630-82-2

Chemical Structure| 620630-82-2

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Product Details of [ 620630-82-2 ]

CAS No. :620630-82-2
Formula : C12H16O6
M.W : 256.25
SMILES Code : OC1=C(C2OC(C)(C)OC2)OC3=C1OC(C)(C)O3
MDL No. :MFCD28099784

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Application In Synthesis of [ 620630-82-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 620630-82-2 ]

[ 620630-82-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 620630-82-2 ]
  • [ 66137-74-4 ]
  • C16H19F8IO9S [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% To a solution of 1,2,5,6-di-O-isopropylidene-alpha-D-allofuranose (781 mg, 3.00 mmol, 1.00 eq.) in dry THF (10.0 mL), was added KHMDS (0.5 M THF solution, 6.80 mL, 3.60 mmol, 1.20 eq.) with ice-cooling in an argon atmosphere, and the mixture was stirred at the same temperature for 30 minutes. To the resulting solution was dropwise added <strong>[66137-74-4]5-iodooctafluoro-3-oxapentanesulfonyl fluoride</strong> (1.40 g, 3.30 mmol, 1.10 eq.) over 30 minutes. The mixture was stirred for further 15 minutes at the same temperature, and then the reaction solution was poured into saturated sodium bicarbonate water. The aqueous phase was extracted twice with ethyl acetate, and then the organic phase was washed with saturated sodium bicarbonate water and a saturated salt solution, and finally dried over magnesium sulfate. The solvent was removed under reduced pressure to obtain a crude product. The obtained crude product was purified by silica gel column chromatography (eluent: hexane:ethyl acetate=92:8) to obtain 1,2,5,6-di-O-isopropylidene-3-O-(5-iodooctafluoro-3-oxapentanesulfonyl)-alpha-D-allofuranose as shown below (1.70 g, 2.55 mmol, 85%).
 

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