Alternatived Products of [ 62150-48-5 ]
Product Details of [ 62150-48-5 ]
CAS No. : | 62150-48-5 |
MDL No. : | MFCD13195089 |
Formula : |
C6H6BrN3O
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | RTLFVRMZSLFBRU-UHFFFAOYSA-N |
M.W : |
216.04
|
Pubchem ID : | 67057353 |
Synonyms : |
|
Application In Synthesis of [ 62150-48-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 62150-48-5 ]
- 1
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[ 62150-47-4 ]
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[ 62150-48-5 ]
Yield | Reaction Conditions | Operation in experiment |
85% |
With ethanol; hydrazine hydrate; at 70℃; for 12.0h; |
To a stirred solution of <strong>[62150-47-4]ethyl 4-bromopicolinate</strong> 5 (15 g, 65.51 mmol) in ethanol (150 mL) was added hydrazine hydrate (6.55 g, 6.42 mL, 131.01 mmol). The reaction mixture was heated at 70 C for 12 h. Upon completion of the reaction (TLC), the solid precipitate was filtered off and dried under vacuum to give compound 6 (85 %). |
0.620 g |
With hydrazine hydrate; In ethanol; at 0 - 20℃; for 0.5h; |
To a stirred solution of <strong>[62150-47-4]ethyl 4-bromopicolinate</strong> (CAS Number 62150-47-4; 0.700 g, 3.04 mmol) in ethanol (7 ml) was added hydrazine hydrate (0.456 g, 9.12 mmol) drop-wise at 0C. The reaction temperature was raised from 0C to rt and stirred for an additional 30 mm. Ethanol wasremoved under reduced pressure. To the crude reaction, was added water (50 ml) and the product was extracted in EtOAc (2 x 50 ml). Combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give 4-bromopicolinohydrazide (0.620 g, 2.88 mmol, Cmde). The cmde solid was directly used for next step without purification. LCMS: Method C, 1.291 mi MS: ES+ 216.13. |