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Chemical Structure| 6224-91-5 Chemical Structure| 6224-91-5

Structure of 6224-91-5

Chemical Structure| 6224-91-5

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Product Details of [ 6224-91-5 ]

CAS No. :6224-91-5
Formula : C6H12Si
M.W : 112.25
SMILES Code : CC#C[Si](C)(C)C
MDL No. :MFCD00009271
InChI Key :DCGLONGLPGISNX-UHFFFAOYSA-N
Pubchem ID :80363

Safety of [ 6224-91-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P210-P261-P305+P351+P338
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 6224-91-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6224-91-5 ]

[ 6224-91-5 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 6224-91-5 ]
  • [ 10016-52-1 ]
  • 2-bromo-8-(prop-1-yn-1yl)dibenzo(b,d)furan [ No CAS ]
YieldReaction ConditionsOperation in experiment
29.9% With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; at 20 - 80℃; To a mixture of (Example 14-1) (4.00g, 12.3 mmol), PPh3(0.03g, 0.12 mmol), Cul (0.47g, 2.46 mmol), PdCI2 (PPh3)2(0.lg, 0.12 mmol), and triethylamine (80 ml was added trimethyl(prop-1-yn-1-yl)silane (2 .1 ml, 18.5 mmol) at room temperature. To the resultant mixture was added a solution of tetrabutylammonium fluoride (TBAF) (1 M in THE, 28.5 ml) over 20 minutes. The mixture was stirred at 8000 overnight. The reaction was quenched with water and extracted with CH2CI2. The organic layer was collected, dried over anhydrous MgSO4 and concentrated in vacuo to yield the product as black oil. The product obtained was then purified by silica gel column chromatography (100percent n-hexane Rf = 0.45) to afford the title compound (Example 14-2) (1 .05g, 29.9percent).
 

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