Alternatived Products of [ 623588-40-9 ]
Product Details of [ 623588-40-9 ]
| CAS No. : | 623588-40-9 |
MDL No. : | MFCD20486596 |
| Formula : |
C8H5ClFNO4
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
233.58
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 623588-40-9 ]
| Signal Word: | |
Class: | |
| Precautionary Statements: | |
UN#: | |
| Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 623588-40-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 623588-40-9 ]
- 1
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[ 234082-35-0 ]
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[ 623588-40-9 ]
| Yield | Reaction Conditions | Operation in experiment |
| 85.11% |
With sulfuric acid; nitric acid; In sulfuric acid; at 25℃; |
Example 2 Nitration process (step (a)) In a 250 ml four-necked round bottom flask, equipped with a mechanical stirrer, condenser and thermometer, 126 g of concentrated sulphuric acid are loaded, 80 g of methyl 3-chloro-4-fluoro-benzoate are added under stirring, the temperature is controlled with a water bath, 31 g of HN03 are added slowly in 3-4 hours. The reaction is only moderately exothermic. At the end of metering, about 20% of the product is still not reacted, so it is left overnight under stirring at 25C. 50 ml of methylene chloride are added, the organic phase is poured into ice, under stirring, then the 2 phases are separated, the organic phase is neutralised with 5% sodium bicarbonate, it is washed again and a liquid is obtained which, after evaporation of the solvent, becomes a pale yellow solid of 92 g corresponding to the compound methyl 5-chloro-4- fluoro-2-nitro-benzoate. Titre 89%, yield = 85. 11 % . |
- 2
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[ 623588-40-9 ]
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[ 2475-81-2 ]
| Yield | Reaction Conditions | Operation in experiment |
| 97.8% |
With ammonium formate;palladium 10% on activated carbon; In water; isopropyl alcohol; at 50℃; for 3h; |
Example 3 Process by reduction and de-halogenation (step (b)) In a 250 mi round bottom flask, under a flow of nitrogen, 10g of methyl 5-chloro-4-fluoro-2-nitro-benzoate of the previous preparation are loaded, it is dissolved with 100 gr of isopropanol, and 5g of Pd/C 10%, 50% wet are added. The reaction mixture is heated to about 50C. A solution of 24.24 g of ammonium formate in 24.24 g of water is prepared. The aqueous solution is metered slowly onto the alcohol solution in about 2 hours. It is then left under stirring for 1 hour, and left to cool. The end of the reaction is controlled with TLC. The Pd/C is filtered on paper, thus obtaining a pale yellow solution containing methyl 2-amino-4-fluoro-benzoate which turns brown in the air. Yield in solution 97.8%. |
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