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Chemical Structure| 624-86-2 Chemical Structure| 624-86-2

Structure of 624-86-2

Chemical Structure| 624-86-2

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Product Details of [ 624-86-2 ]

CAS No. :624-86-2
Formula : C2H7NO
M.W : 61.08
SMILES Code : NOCC
MDL No. :MFCD03703420
InChI Key :AQFWNELGMODZGC-UHFFFAOYSA-N
Pubchem ID :69357

Safety of [ 624-86-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P210-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 624-86-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 624-86-2 ]

[ 624-86-2 ] Synthesis Path-Downstream   1~1

  • 1
  • 4,5-dihydroxyornithine-N2 -[4'-n-octyloxy[1,1'-biphenyl]-4-carbonyl]pneumocandin B0 [ No CAS ]
  • [ 2002-24-6 ]
  • [ 75-05-8 ]
  • [ 624-86-2 ]
YieldReaction ConditionsOperation in experiment
98% With camphor-10-sulfonic acid; In 4,5-Dihydroxyomithine-N2[-4'-n-octyloxy[1,1'-biphenyl]-4-carbonyl]Pneumocandin B0; dimethyl sulfoxide; Part B. Preparation of the Aminoethylether A solution of 4,5-dihydroxyornithine-N2 -[4'-n-octyloxy[1,1'-biphenyl]-4-carbonyl]pneumocandin B0. (0.350 g, prepared in Part A), ethanolamine hydrochloride (1.2 g) and camphorsulfonic acid (0.0716 g) in 4 mL of anhydrous dimethylsulfoxide was stirred at 25 C. for 4 days. The mixture was diluted five-fold with water. Prepurification was accomplished on Lichroprep C-18 (80% aqueous acetonitrile to 70% aqueous acetonitrile). The product containing fractions were combined and lyophilized to obtain the crude Compound Ib. Purification by preparative HPLC (DeltaPak, 60% aqueous acetonitrile/0.1% trifluoroacetic acid, 220 nm) gave 80 mg of the desired product (>98% pure) as the trifluoroacetate salt after lyophilization. Partial 1 H NMR (400 MHz, CD3 OD) delta 1.19 (d, 3H), 1.79 (m, 2H), 2.85 (dd, 1H), 3.71 (m, 2H), 3.82 (m, 2H), 4.01 (t, 2H), 5.06 (dd, 1H), 5.11 (dd, 1H), 5.35 (d, 1H), 6.77 (d, 2H), 7.01 (d, 2H), 7.14 (d, 2H), 7.61 (d, 2H), 7.69 (d, 2H), 7.92 (d, 2H). Mass spectrum (M+H): 1178.6.
 

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