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Chemical Structure| 62415-75-2 Chemical Structure| 62415-75-2

Structure of 62415-75-2

Chemical Structure| 62415-75-2

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Product Details of [ 62415-75-2 ]

CAS No. :62415-75-2
Formula : C11H8Br2
M.W : 299.99
SMILES Code : CC1=CC(Br)=C2C=CC=CC2=C1Br

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Application In Synthesis of [ 62415-75-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 62415-75-2 ]

[ 62415-75-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 62415-75-2 ]
  • [ 952514-79-3 ]
  • C49H34N4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
35.8% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 80℃; for 16h; 1,4-Dibromo-2-methyl-naphthalene (10 g,34.69 mmol), 4- (1 -phenyl-1 H-benzimidazol-2- yl) phenylboronic acid (4- (. 1-phenyl-IH-benzimidazol-2-yL) phenylboronic acid) (23.17 g of, 76.91mmol), potassium carbonate (24.16g, 157.96mmol) and Pd (PPh3. 3). 4(4.04 g) into a reaction flask, add 150 ml of toluene, 30 ml of ethanol and 60 ml of deionized water, and stir andreflux for 16 hoursat 80 C.After the reaction, add 100 ml deionized water and stir to room temperature, filter out the solid, add250 mltetrahydrofuran andstir until the solid is completely dissolved, pass through a silica gel column, concentrate by distillation, add ethyl acetate and filter out thesolid , Compound A2 was dried to give a white solid (8.5 g, 35.8% yield).
  • 2
  • [ 62415-75-2 ]
  • [ 626-13-1 ]
  • C39H36N2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.8 g With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate; In toluene; at 50 - 60℃; 1,4-Dibromo-2-methylnaphthalene (3 g, 10 mmol) and di-m-tolylamine (4.14 g, 21 mmol) were added in a reaction flask. After the toluene was sufficiently dry, dry toluene (35 mL) was added thereto, and then the mixture was heated and stirred. Sodium t-butoxide (2.49 g, 2.6 mmol) was added when the mixture was heated to 50 C., and the mixture was heated and stirred again. Pd(OAc)2 (0.067 g, 0.3 mmol) and tri-tert-butylphosphine (0.1728 g, 0.8 mmol) were added when the temperature reached 60 C., and the reaction underwent overnight. After the reaction completed, deionized water (50 mL) was added, and the mixture was stirred for 30 minutes. Solid was filtered, and the organic layer was collected after removing the aqueous layer from the filtrate. The organic layer was purified through silicon chromatography, and the purified organic layer and the solid filtered were combined and concentrated via distillation. Methanol (100 mL) was added for precipitation, and the precipitate was filtered to obtain Compound A4 (1.8 g) as a pale-yellow solid. 1H NMR (400 MHz, CDCl3, delta):delta 7.97-7.9 (dd, 3H); 7.35-7.24 (m, 5H); 7.23-7.1 (s, 2H); 7.14-7.05 (m, 8H); 6.91-6.86 (s, 6H); 6.83-6.8 (t, 6H); 6.79-6.745 (d, 3H); 6.74-6.685 (d, 3H).
 

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