Home Cart Sign in  
Chemical Structure| 62482-26-2 Chemical Structure| 62482-26-2

Structure of 62482-26-2

Chemical Structure| 62482-26-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 62482-26-2 ]

CAS No. :62482-26-2
Formula : C11H8ClNO2
M.W : 221.64
SMILES Code : O=C(C1=CC(Cl)=NC2=CC=CC=C12)OC
MDL No. :MFCD03413689
InChI Key :TZKVCCWVZWZXKK-UHFFFAOYSA-N
Pubchem ID :5202936

Safety of [ 62482-26-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P260-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 62482-26-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 62482-26-2 ]

[ 62482-26-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 5467-57-2 ]
  • [ 62482-26-2 ]
  • [ 114935-92-1 ]
YieldReaction ConditionsOperation in experiment
Preparation 17 Methyl 2-chloroquinoline-4-carboxylate Utilizing substantially the same procedure as recited in Preparation 16, but substituting <strong>[5467-57-2]4-carboxy-2-chloroquinoline</strong> (Bader, 1001 West Saint Paul Avenue, Milwaukee, Wis., 53233 USA) for 4-chloroquinaldic acid, the title compound of this Preparation was prepared. 1 H NMR (DMSO-d6): delta 8.56 (1H, d, J=7), 8.05 (1H, d, J=7), 7.94 (1H, s), 7.92 (1H, ddd, J=9,7,1), 7.78 (1H, ddd, J=9,7,1), 4.00 (3H, s).
  • 2
  • [ 5467-57-2 ]
  • [ 74-88-4 ]
  • [ 62482-26-2 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 20℃;Inert atmosphere; [Reference Example 3] Synthesis of <strong>[5467-57-2]2-chloro-4-quinolinecarboxylic acid</strong> methyl ester Potassium carbonate (5.55 g, 40.2 mmol) and methyl iodide (1.88 mL, 30.2 mmol) were added to a DMF (25 mL) solution of commercially available <strong>[5467-57-2]2-chloro-4-quinolinecarboxylic acid</strong> (4.17 g, 20.1 mmol), and the mixture was stirred overnight at room temperature in an argon atmosphere. The reaction solution was added to a saturated aqueous solution of sodium chloride, and the deposited crystal was collected by filtration, washed with water, and dried to obtain the title compound (3.53 g, 15.9 mmol) as a pale yellow solid. ES-MS (m/z): 224 (37ClM + H)+, 222 (35ClM + H)+.
  • 3
  • [ 67-56-1 ]
  • [ 5467-57-2 ]
  • [ 62482-26-2 ]
YieldReaction ConditionsOperation in experiment
78.2% c) <strong>[5467-57-2]2-chloroquinoline-4-carboxylic acid</strong> (9.8 g, 47 mmol) was dissolved in 50 mL of dichloromethane. A catalytic amount of DMF was dropped, oxalyl chloride (7.9 mL, 94 mmol) was slowly added dropwise under ice bath, reacted at room temperature for 2 h, 20 mL of methanol was added, and stirred continuously for 1 h.The solvent was evaporated, diluted with water and extracted with dichloromethane (50 mL×3). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated to obtain 8.2 g of methyl 2-chloroquinoline-4-carboxylate. Yield 78.2percent. Methyl 2-methylquinoline-4-carboxylate (8.2 g, 37 mmol) was dissolved in methanol, NaBH4 (4.2 g, 111 mol) was added in portions under ice bath conditions, stirred at room temperature for 24 hours, the reaction solution was poured into a saturated aqueous solution of ammonium chloride, methanol was distilled off and extracted with dichloromethane (50 mL×3). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated to obtain 2-chloroquinoline-4-methanol 5g, the yield is 70.4percent. 2-chloroquinoline-4-methanol (5 g, 25.8 mmol) was dissolved in 30 mL of DMSO, IBX (8g, 28.4mmol) was aded, reacted at room temperature for 2h. Then the reaction solution was poured into water, extracted with ethyl acetate (50 mL × 3), the organic phases were combined, washed with 10percent aqueous NaOH solution three times, washed with saturated saline, dried over anhydrous sodium sulfate, concentrated and 4.2 g of 2-chloroquinoline-4-carbaldehyde was obtained in a yield of 84percent. 2-chloroquinoline-4-carbaldehyde (4.2 g, 22 mmol) was dissolved in dry THF, 3 mol/L ethylmagnesium bromide in diethyl ether (15 mL, 44 mmol) was slowly injected under nitrogen, reacted at room temperature for 2 h, diluted with water, extracted with dichloromethane (50mL × 3), the organic phase was combined and washed with saturated brine, dried over anhydrous sodium sulfate, concentrated and purified by column chromatography (PE/EA 2:1) to obtain 3.5 g as colorless oil, yield 72.9percent; The product from the previous step (2 g, 9 mmol) was dissolved in dichloromethane, Dess Martin reagent (3g, 10.8mmol) was added and stirred at room temperature for 2h, diluted with water, extracted with dichloromethane (50mL × 3), organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated and purified by column chromatography (PE/EA 2:1) to obtain 2-chloro-4-propionylquinoline 1.3 g in a yield of 65.0percent.
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 62482-26-2 ]

Chlorides

Chemical Structure| 1192569-38-2

A162492 [1192569-38-2]

Methyl 2-chloroquinoline-5-carboxylate

Similarity: 1.00

Chemical Structure| 1094217-62-5

A321773 [1094217-62-5]

Methyl 2-chloro-6-methylquinoline-4-carboxylate

Similarity: 1.00

Chemical Structure| 1617517-85-7

A896718 [1617517-85-7]

Ethyl 2-chloro-5-methylquinoline-4-carboxylate

Similarity: 0.97

Chemical Structure| 5467-61-8

A244854 [5467-61-8]

Ethyl 2-chloroquinoline-4-carboxylate

Similarity: 0.97

Chemical Structure| 849807-09-6

A413112 [849807-09-6]

Methyl 2-chloroquinoline-6-carboxylate

Similarity: 0.96

Esters

Chemical Structure| 1192569-38-2

A162492 [1192569-38-2]

Methyl 2-chloroquinoline-5-carboxylate

Similarity: 1.00

Chemical Structure| 1094217-62-5

A321773 [1094217-62-5]

Methyl 2-chloro-6-methylquinoline-4-carboxylate

Similarity: 1.00

Chemical Structure| 1617517-85-7

A896718 [1617517-85-7]

Ethyl 2-chloro-5-methylquinoline-4-carboxylate

Similarity: 0.97

Chemical Structure| 5467-61-8

A244854 [5467-61-8]

Ethyl 2-chloroquinoline-4-carboxylate

Similarity: 0.97

Chemical Structure| 849807-09-6

A413112 [849807-09-6]

Methyl 2-chloroquinoline-6-carboxylate

Similarity: 0.96

Related Parent Nucleus of
[ 62482-26-2 ]

Quinolines

Chemical Structure| 1192569-38-2

A162492 [1192569-38-2]

Methyl 2-chloroquinoline-5-carboxylate

Similarity: 1.00

Chemical Structure| 1094217-62-5

A321773 [1094217-62-5]

Methyl 2-chloro-6-methylquinoline-4-carboxylate

Similarity: 1.00

Chemical Structure| 1617517-85-7

A896718 [1617517-85-7]

Ethyl 2-chloro-5-methylquinoline-4-carboxylate

Similarity: 0.97

Chemical Structure| 5467-61-8

A244854 [5467-61-8]

Ethyl 2-chloroquinoline-4-carboxylate

Similarity: 0.97

Chemical Structure| 849807-09-6

A413112 [849807-09-6]

Methyl 2-chloroquinoline-6-carboxylate

Similarity: 0.96