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CAS No. : | 626-72-2 | MDL No. : | MFCD00020391 |
Formula : | C8H16N2O4S2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 268.35 | Pubchem ID : | - |
Synonyms : |
|
Chemical Name : | (H-HoCys-OH)2 |
Num. heavy atoms : | 16 |
Num. arom. heavy atoms : | 0 |
Fraction Csp3 : | 0.75 |
Num. rotatable bonds : | 9 |
Num. H-bond acceptors : | 6.0 |
Num. H-bond donors : | 4.0 |
Molar Refractivity : | 64.71 |
TPSA : | 177.24 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -11.88 cm/s |
Log Po/w (iLOGP) : | 0.91 |
Log Po/w (XLOGP3) : | -5.56 |
Log Po/w (WLOGP) : | -0.03 |
Log Po/w (MLOGP) : | -5.14 |
Log Po/w (SILICOS-IT) : | -0.62 |
Consensus Log Po/w : | -2.09 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 1.0 |
Egan : | 1.0 |
Muegge : | 2.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | 2.59 |
Solubility : | 105000.0 mg/ml ; 392.0 mol/l |
Class : | Highly soluble |
Log S (Ali) : | 2.5 |
Solubility : | 84200.0 mg/ml ; 314.0 mol/l |
Class : | Highly soluble |
Log S (SILICOS-IT) : | 0.15 |
Solubility : | 380.0 mg/ml ; 1.42 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 3.42 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | Stage #1: at -78 - 35℃; Inert atmosphere Stage #2: at -78℃; for 0.333333 h; |
FIRST EMBODIMENTIn a 500-ml three-necked flask equipped with a liquid-ammonia cooling device, a glass stirring bar, a thermometer, and a septum rubber cap was placed 10.0 g (37.3 mmol) of L-homocystine, followed by thorough purging of the flask with nitrogen. After cooling the flask to -78° C., ammonia which had been dried by passing through a KOH tube was liquefied in the liquid-ammonia cooling device cooled on a dry ice-acetone bath, and the liquid ammonia was added in a volume of about 100 ml to L-homocystine, followed by stirring. Next, 3.58 g (156 mmol) of metallic sodium was gradually added while avoiding rise of the temperature of the mixture above -35° C. The solution (mixture) became dark blue in this step. Next, 18.2 g (93.3 mmol) of trifluoromethyl iodide weighed using a balloon was added, the mixture was stirred on a bath at -78° C. for 20 minutes, from which ammonia was gradually evaporated, the residue was dissolved in ultrapure water, and the solution was placed on an ion exchange resin DOWEX-50X8 which had been treated with hydrochloric acid. After passing a sufficient amount of ultrapure water, elution with a 2percent aqueous ammonia solution was performed, and thereby yielded 14.1 g of target L-trifluoromethionine in a yield of 93percent.1H-NMR (D2O, 200 MHz) δ: 2.07-2.37 (m, 2H) , 3.01 (t, 2H, J=7.6 Hz), 4.03 (t, 1H, J=6.6 Hz)19F-NMR (D2O, 188 MHz) δ: -41.3 (s) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With thionyl chloride;Inert atmosphere; | To a suspension of <strong>[626-72-2]l-homocystine</strong> (2.0g, 7.50mmol) in methanol (95mL) was carefully added thionyl chloride (1.1mL, 30.1mmol) drop wise over 30min. The reaction was stirred under nitrogen overnight, and then it was concentrated under reduced pressure to provide a yellow solid (2.78g, quantitative yield). 1H NMR (500MHz, CD3OD) delta 4.21 (s, 2H), 3.86 (s, 3H), 3.33 (m, 1H), 2.90 (m, 2H), 2.36 (d, J=27.4Hz, 2H). 13C NMR (125MHz, CD3OD) delta 169.3, 53.1, 51.7, 51.7, 32.8, 29.9. HRMS: (ESI) calcd for C10H20N2O4S2 [M+ H]+ 297.0943; found 297.0949. |
96% | With thionyl chloride; at 80℃;Cooling with ice; | Synthetic Example 26; Methyl (L)-4,4'-disulfanediyl-bis(2-(benzoxazol-2-yl)amino)-buty rate; Step 1 : f2S.2'SVDimethyl 4.4'-disulfanediyl-bisf2-aminobutanoate); Thionyl chloride (SOCl2) (11.9 g, 100 mmol) was added slowly to MeOH (250 mL) in an ice-bath. <strong>[626-72-2]L-Homocystine</strong> (13.4 g, 50 mmol) was added to the solution. The resulting mixture was continuously stirred overnight at 8O0C. The reaction mixture was concentrated in vacuum, and CHCl3 (250 mL) was added. This mixture was then concentrated and dried under high vacuum to afford the desired homocystine bis-ester as a solid (14.2 g, 96 %). ESI-MS: 297.1(M+H)+. HPLC purity: 100% (254 nm). |
With thionyl chloride; at 0℃; for 3h;Reflux;Product distribution / selectivity; | Step 1: (S)-2-Amino-4-((S)-3-amino-3-methoxycarbonyl-propyldisulfanyl)-butyric acid methyl ester. Thionyl chloride (0.5 mL, 8.20 mmol) was slowly added to a stirred solution of (S)-2-amino-4-((S)-3-amino-3-carboxy-propyldisulfanyl)-butyric acid (available from 3B Scientific Corporation, Libertyville, Ill. 60048, USA; 1.0 g, 3.73 mmol) in methanol (12.5 mL) at 0 C. The mixture was then subjected to reflux for 3 h, during which time the reaction went to completion (monitored by silica TLC). The reaction mixture was cooled to room temperature and solvent was distilled off under reduced pressure to give crude (S)-2-amino-4-((S)-3-amino-3-methoxycarbonyl-propyldisulfanyl)-butyric acid methyl ester (1.0 g, 90%) as white solid, which was carried on to the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With fluorone black; In methanol; water; at 20℃; for 0.0833333h;pH 7.3; | General procedure: Example 3 An alternative method for the selective detection of homocysteine employs fluorone black, Compound 4. (See FIG. 2.) Following the addition of a thiol (Hcy, Cys, or GSH) to a solution of Compound 4 (1.0×10-5 M) in 70% MeOH/H2O (phosphate buffer, H2O, pH=7.3), an increase in absorbance occurred at 510 nm at room temperature (analysis after 5 min). The absorbance increase was greatest for Hcy as compared to equimolar amounts of the other two biothiol analytes. Amino acids lacking thiol functionality, such as L-alanine, L-arginine, L-glutamine, glycine, L-lysine, L-methionine, L-serine, and L-threonine, did not produce substantial spectral changes at 510 nm as compared to solutions of Compound 4 without analyte. Note in particular that methionine, which contains a sulfur atom but not a thiol group, did not produce a substantial spectral change at 510 nm. We have discovered that potential interferences may be minimized, and outstanding selectivity achieved, by the addition of a reducing agent such as a phosphine derivative (5 equiv. to analyte in this example). Without wishing to be bound by this theory, our findings suggested a process in which Compound 4 was involved in the redox chemistry of the thiols. 1H NMR studies showed that conversion of homocysteine (the reduced, thiol form, RSH) to homocystine (the oxidized, disulfide form of homocysteine, RSSR) was enhanced in the presence of Compound 4. Additionally, the MALDI mass spectrum of products formed in a solution containing Compound 4 and Hcy exhibited prominent peaks for the sodium salt of glycine, and for the disodium and dipotassium salts of a glycine-derived dimer. Glycine and its dimerization products are known to be termination products of alpha-amino acid carbon-centered radicals. MALDI TOF MS (anthracene matrix), calculated for glycine sodium salt C2H4NNaO2 (M+Na)+ 97.01. found 96.89; calculated for glycine dimer (2,3-diaminosuccinic acid disodium salt) C4H6Na2N2O4 (M+2Na)+ 192.01. found 193.05; calculated for glycine dimer (2,3-diaminosuccinic acid dipotassium salt) C4H6K2N2O4 (M+2K)+ 223.96. found 223.86. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With sodium carbonate; In 1,4-dioxane; water; at 20℃;Inert atmosphere; | Modification of published procedure.13 To a solution of <strong>[626-72-2]l-homocystine</strong> (1.00 g, 3.73 mmol) in 1 M aqueous sodium carbonate (33.5 mL) was added dioxane (30 mL) under ambient conditions. Boc2O (1.72 g, 7.88 mmol) was added in one portion. The cloudy reaction mixture was stirred overnight at room temperature. A 10% w/v solution of aqueous citric acid was added to the milky reaction mixture dropwise at 0 C. During acidification, the reaction mixture first clarifies while visibly evolving gas (to pH ?5.5) and then becomes gelatinous (at pH ?4.5). The gelled product was extracted with four portions of EtOAc (40 mL). The organic layers were combined and washed with five portions of dH2O and one portion of brine (40 mL) and dried over MgSO4. After filtration, solvent was removed via rotary evaporation to give a dry, crusty white solid (1.52 g, 3.24 mmol, 87%). The product could be used without further purification but could also be recrystallized from ethyl acetate. The solid powder is stable indefinitely at room temperature. TLC (2:1 EtOAc/hexanes): Rf 0.48; 1H NMR (500 MHz, CD3OD): delta 4.22 (dd, J = 9.2 Hz, J = 4.6 Hz, 1H), 2.76 (m, 2H), 2.24 (m, 1H), 2.00 (m, 1H), 1.45 (s, 9H); 13C NMR (125 MHz, CD3OD): delta 175.9, 158.1, 80.6, 53.9, 35.7, 32.6, 28.7; IR (ATR): 3374 (amide), 2982, 2923 (acid), 2507, 1729 (acid), 1684 (amide), 1520, 1413 cm-1. NMR data are consistent with published reports.13 |
<strong>[626-72-2]L-homocystine</strong> (0.50 g) was dissolved in 20 mL 1,4-dioxane and treated with NaOH solution (0.313 g in 20 mL H2O). The mixture was stirred for 10 min. and then treated with di-tert-butyl carbonate (1.02 g). The reaction was stirred overnight and was allowed to warm to room temperature slowly. 10 mL HCl (1M) was then added into the mixture to adjust pH to 1, and the mixture was extracted using ethyl acetate. The organic layer was separated and the solvent was removed to give the crude homocystine-boc, as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20℃; for 2.3h;pH 9; | <strong>[626-72-2]L-homocystine</strong> (5 g) was dissolved in a mixture (80 ml) of dioxane/H2O. At 0 C. and under stirring, 1.52 g (2.1 eq) of NaOH and a solution of 7.8 g (2.4 eq) of benzylchloroformate in 40 ml dioxane were added. The pH was maintained at 9 by addition of a solution of NaOH 1M. After stirring for 2.30 h at room temperature, 100 ml H2O were added and the white precipitate was extracted by Et20 (2×50 ml). The aqueous phase was acidified to pH 1 and the precipitate was extracted by EtOAc (4×80 ml). The organic phase was washed, dried over Na2SO4, filtered and evaporated in vacuo. White solid 10.2 g (100%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | SECOND EMBODIMENTIn a 200-ml three-necked flask equipped with a liquid-ammonia cooling device, a glass stirring bar, a thermometer, and a septum rubber cap was placed 1.00 g (3.73 mmol) of <strong>[626-72-2]L-homocystine</strong>, followed by thorough purging of the flask with nitrogen. After cooling the flask to -78 C., ammonia which had been dried by passing through a KOH tube was liquefied in the liquid-ammonia cooling device cooled on a dry ice-acetone bath, and the liquid ammonia was added in a volume of about 50 ml to <strong>[626-72-2]L-homocystine</strong>, followed by stirring. Next, 358 mg (15.6 mmol) of metallic sodium was gradually added while avoiding rise of the temperature of the mixture above -35 C. The solution (mixture) became dark blue in this step. Next, 2.29 g (9.33 mmol) of pentafluoroethyl iodide weighed using a balloon was added, the mixture was stirred on a bath at -78 C. for 20 minutes, from which ammonia was gradually evaporated, the resulting residue was dissolved in ultrapure water to give a solution, the solution was placed on the ion exchange resin DOWEX-50X8 which had been treated with hydrochloric acid. After passing a sufficient amount of ultrapure water, elution with a 2% aqueous ammonia solution was performed, and thereby yielded 1.27 g of target L-pentafluoroethylhomocysteine (L-pentafluoroethionine) in a yield of 67%.1H-NMR (D2O, 200 MHz) delta: 2.03-2.34 (m, 2H) , 3.01 (t, 2H, J=7.6 Hz), 4.04 (t, 1H, J=6.6 Hz)19F-NMR (D2O, 188 MHz) delta: -93.8 (s), -85.3 (s) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | (FIG. 10, used for compounds 3, 4, 5, 8-19, 21-23, 25, 26 and 28-30). L,<strong>[626-72-2]L-homocystine</strong> (100 mg, 0.37 mmol) (from Bachem, Torrance, Calif., USA) was added to 20 mL liquid ammonia at -78 C. and stirred until fully dissolved. Small fragments of sodium metal (34 mg, 1.5 mmol) were added until a deep blue color persisted for at least 1 min. The corresponding alkyl bromide (2.0 eq) was then introduced, which caused the blue solution to quickly proceed to a mixture with a white precipitate. Ammonium chloride (20 mg, 0.37 mmol) was then added to the reaction and the reaction was immediately removed from the cooling bath. The reaction flask was left open to the atmosphere at ambient temperature to allow ammonia to evaporate. The resulting residue was dissolved in 5 mL deionized water and the pH was adjusted to pH 5-7 by the addition of 1 M HCl. The solvent was removed under reduced pressure and the residue was dried. A fraction (10 mg) of the dried residue was dissolved with 400 muL dH2O with 0.1% TFA, adjusted to pH 3 by the addition of 1 M HCl, centrifuged and subsequently purified by semi-preparative HPLC (Method B) to ultimately afford the desired S-alkylated L-methionine analogs in 22%-99% yield. (2S)-2-amino-4-(propylsulfanyl)butanoic acid (compound 8) . A protocol identical to that described for compound 3 using <strong>[626-72-2]L-homocystine</strong> (150 mg, 0.559 mmol) and 1-bromopropane (112 muL, 1.23 mmol) gave compound 8 (181 mg, 91% yield) as a white amorphous solid. 1H NMR (DMSO-d6/TFA-d1=20/1, 400 MHz) delta 4.05 (t, J=6.8 Hz, 1H), 2.61 (m, 2H), 2.50 (t, J=7.3 Hz, 2H), 2.03-2.09 (m, 2H), 1.56 (quin, J=7.3 Hz, 2H), 0.96 (t, J=7.2 Hz, 3H); 13C NMR (DMSO-d6/TFA-d1=20/1, 125 MHz) delta 171.2, 51.5, 33.3, 30.6, 26.9, 22.9, 13.6; HRESI calculated for C7H16NO2S ([M+H]+) m/z 178.0896; measured m/z 178.0900. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | With ammonia; sodium hydroxide; In water-d2; for 1h; | Some modifications of the strategy illustrated in were employed for the synthesis of compound 3. Specifically, the dried residue after completion of the <strong>[626-72-2]L-homocystine</strong> (250 mg, 0.932 mmol)/iodoethane (165 muL, 2.04 mmol) and subsequent evaporation of NH3 was dissolved in ddH2O (30 mL) and solid NaOH (1.20 g, 0.03 mol) was added, creating a 1 M sodium hydroxide solution. After stirring for 1 h, the basic solution was slowly loaded onto a Dowex 50W8X-200 2.5 cm*3 cm column prequilibrated with ddH2O. The column was washed with several column volumes of ddH2O and the product subsequently eluted with 2.5% aqueous NH4OH. The fractions, identified by TLC (15:1:84 MeOH/NH4OH/CHCl3, ninhydrin stain), were combined and lyophilized to a white amorphous solid (184 mg, 61% yield). 1H NMR (DMSO-d6/TFA-d1=20/1, 500 MHz) delta 4.01 (t, J=6.2 Hz, 1H), 2.48-2.64 (m, 2H), 2.49 (q, J=7.3 Hz, 2H), 2.00 (m, 2H), 1.17 (t, J=7.3 Hz, 3H); 13C NMR (DMSO-d6/TFA-d1=20/1, 125 MHz) delta 175.9, 56.3, 35.4, 31.4, 30.0, 20.1; HRESI calculated for C6H14NO2S ([M+H]+) m/z 164.0740; measured m/z 164.0744. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75%; 6% | (FIG. 10, used for compounds 3, 4, 5, 8-19, 21-23, 25, 26 and 28-30). L,<strong>[626-72-2]L-homocystine</strong> (100 mg, 0.37 mmol) (from Bachem, Torrance, Calif., USA) was added to 20 mL liquid ammonia at -78 C. and stirred until fully dissolved. Small fragments of sodium metal (34 mg, 1.5 mmol) were added until a deep blue color persisted for at least 1 min. The corresponding alkyl bromide (2.0 eq) was then introduced, which caused the blue solution to quickly proceed to a mixture with a white precipitate. Ammonium chloride (20 mg, 0.37 mmol) was then added to the reaction and the reaction was immediately removed from the cooling bath. The reaction flask was left open to the atmosphere at ambient temperature to allow ammonia to evaporate. The resulting residue was dissolved in 5 mL deionized water and the pH was adjusted to pH 5-7 by the addition of 1 M HCl. The solvent was removed under reduced pressure and the residue was dried. A fraction (10 mg) of the dried residue was dissolved with 400 muL dH2O with 0.1% TFA, adjusted to pH 3 by the addition of 1 M HCl, centrifuged and subsequently purified by semi-preparative HPLC (Method B) to ultimately afford the desired S-alkylated L-methionine analogs in 22%-99% yield. FIG.10 with propargyl bromide yielded compound 4 (4.5 mg, 75% yield) as a white solid together with compound 5 (0.3 mg) as a white oil. 1H NMR (D2O/TFA=20/1, 400 MHz) delta 4.09 (t, J=6.4 Hz, 1H), 3.24 (d, J=2.8 Hz, 2H), 2.74 (t, J=6.8 Hz, 2H), 2.53 (t, J=2.4 Hz, 1H), 2.07-2.26 (m, 2H); 13C NMR (D2O/TFA=20/1, 100 MHz) delta 171.3, 80.0, 72.0, 51.4, 28.8, 26.0, 17.8; HRESI calculated for C7H12NO2S ([M+H]+) m/z 174.0583; measured m/z 174.0582. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With ammonia; In water; | A protocol similar to that described for compound 3 using <strong>[626-72-2]L-Homocystine</strong> (250 mg, 0.93 mmol) and benzyl bromide (0.13 mL, 1.12 mmol) was employed with slight modifications. Specifically, after the evaporation of NH3 the dried residue was dissolved in 15 mL ddH2O and the pH subsequently adjusted to 7 by adding 1 M HCl. A heavy precipitate formed, which was filtered and washed with cold ddH2O (3*10 mL). The filtrate was purified by recrystallization from ethanol to provide compound 22 (0.15 g, 72% yield). |
Tags: 626-72-2 synthesis path| 626-72-2 SDS| 626-72-2 COA| 626-72-2 purity| 626-72-2 application| 626-72-2 NMR| 626-72-2 COA| 626-72-2 structure
[ 59-51-8 ]
2-Amino-4-(methylthio)butanoic acid
Similarity: 0.78
[ 348-67-4 ]
(R)-2-Amino-4-(methylthio)butanoic acid
Similarity: 0.78
[ 63-68-3 ]
(S)-2-Amino-4-(methylthio)butanoic acid
Similarity: 0.78
[ 56-89-3 ]
(2R,2'R)-3,3'-Disulfanediylbis(2-aminopropanoic acid)
Similarity: 0.72
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P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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