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Chemical Structure| 62626-61-3 Chemical Structure| 62626-61-3

Structure of 62626-61-3

Chemical Structure| 62626-61-3

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Product Details of [ 62626-61-3 ]

CAS No. :62626-61-3
Formula : C6H6N2O
M.W : 122.12
SMILES Code : N#CC(N)C1=CC=CO1

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Application In Synthesis of [ 62626-61-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 62626-61-3 ]

[ 62626-61-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 62626-61-3 ]
  • [ 53137-27-2 ]
  • [ 3157-34-4 ]
  • CDI [ No CAS ]
  • [ 119778-28-8 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; 1,1'-carbonyldiimidazole; In dichloromethane; di-isopropyl ether; ethyl acetate; SYNTHESIS EXAMPLE 5 Synthesis of N-(alpha-cyanofurfuryl)-<strong>[53137-27-2]2,4-dimethylthiazole-5-carboxylic acid</strong> amide (compound No. 2) by the CDI method 4.0 g of alpha-(2-furyl)-alpha-aminoacetonitrile hydrochloride and a mixture of 3.70 g of a 50% aqueous soution of NaOH and 50 ml of isopropyl ether were stirred at 40 C. for 1 hour under a nitrogen gas. The isopropyl ether layer was separated. Separately, while 4.71 g of <strong>[53137-27-2]2,4-dimethylthiazole-5-carboxylic acid</strong> and 4.88 g of carbonyldiimidazole (CDI) were stirred in 50 ml of methylene chloride, the alpha-(2-furyl)-alpha-aminoacetonitrile in isopropyl ether was added dropwise under ice cooling. The mixture was left to stand overnight at room temperature, and distilled under reduced pressure to remove the solvent. The residue was dissolved in ethyl acetate, separated, washed with water, and dried over sodium sulfate. The ethyl acetate layer was distilled under reduced pressure to remove the solvent. The residue was recrystallized from isopropyl ether to give 5.51 g (yield 70.4%) of the desired N-(alpha-cyanofurfuryl)-<strong>[53137-27-2]2,4-dimethylthiazole-5-carboxylic acid</strong> amide.
 

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