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Chemical Structure| 632344-06-0 Chemical Structure| 632344-06-0

Structure of 632344-06-0

Chemical Structure| 632344-06-0

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Product Details of [ 632344-06-0 ]

CAS No. :632344-06-0
Formula : C4H8F3N
M.W : 127.11
SMILES Code : CC(NC)C(F)(F)F
MDL No. :MFCD18736307

Safety of [ 632344-06-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 632344-06-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 632344-06-0 ]

[ 632344-06-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 908240-50-6 ]
  • [ 632344-06-0 ]
  • 2-chloro-N-methyl-N-(1,1,1-trifluoropropan-2-yl)pyrido[3,4-d]pyrimidin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
74% In a 20ml_ vial <strong>[908240-50-6]2,4-dichloropyrido[3,4-d]pyrimidine</strong> (600 mg, 3.0 mmol) was stirred in DMSO (0.7ml_) at room temperature and degassed with N2. DIEA (1 mL, 6 mmol) was added and stirred for 5 minutes then KF (174 mg, 3 mmol). This mixture was stirred at room temperature for 15 minutes then racemic 1 , 1 , 1 -trifluoro-N-methylpropan-2-amine (419 mg, 3.3 mmol) was added and degassed then stirred at 60°C for 4 hours. The reaction was then concentrated and purified by flash chromatography on a CO MB I FLASH® system (ISCO) using 0-10percent MeOH/DCM to afford 2-chloro-N-methyl-N-(1 , 1 ,1 -trifluoropropan-2- yl)pyrido[3,4-d]pyrimidin-4-amine (680 mg, 74percent). 1 H NMR (500 MHz, Acetone-d6) delta 9.09 (d, J = 0.9 Hz, 1 H), 8.59 (d, J = 5.9 Hz, 1 H), 8.22 (dd, J = 5.9, 0.9 Hz, 1 H), 5.93 (dddd, J = 15.3, 8.3, 7.0, 1 .2 Hz, 1 H), 3.61 (q, J = 1 .0 Hz, 3H), 1 .63 (d, J = 7.0 Hz, 3H). LCMS (m/z [M+H]+): 291 .7.
 

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