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Chemical Structure| 63333-25-5 Chemical Structure| 63333-25-5

Structure of 63333-25-5

Chemical Structure| 63333-25-5

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Product Details of [ 63333-25-5 ]

CAS No. :63333-25-5
Formula : C10H10F3NO
M.W : 217.19
SMILES Code : O=CC1=CC=C(N(C)C)C=C1C(F)(F)F
MDL No. :MFCD23130686

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Application In Synthesis of [ 63333-25-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 63333-25-5 ]

[ 63333-25-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 90176-80-0 ]
  • [ 124-40-3 ]
  • [ 63333-25-5 ]
YieldReaction ConditionsOperation in experiment
70% With potassium carbonate; In ethanol; N,N-dimethyl-formamide; at 110℃;sealed tube; A suspension of <strong>[90176-80-0]4-fluoro-2-trifluoromethylbenzaldehyde</strong> (500 mg, 2.60 mmol), dimethylamine (5.5 mol/L in ethanol, 0.95 mL, 5.2 mmol), potassium carbonate (360 mg, 2.6 mmol) in 5.2 mL of N,N-dimethylformamide was stirred at 110 C. overnight in a sealed tube. After the reaction mixture was diluted with water, the solution was extracted with ether. The extract was washed with brine, and dried over MgSO4. After filtration, the filtrate was concentrated in vacuo, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=85/15 to 75/25) to obtain the title compound as a pale yellow powder (393 mg, 70%).
 

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