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Chemical Structure| 6336-42-1 Chemical Structure| 6336-42-1

Structure of 6336-42-1

Chemical Structure| 6336-42-1

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Product Details of [ 6336-42-1 ]

CAS No. :6336-42-1
Formula : C12H10ClN5
M.W : 259.69
SMILES Code : ClC1=C2N=CN(CC3=CC=CC=C3)C2=NC(N)=N1

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Application In Synthesis of [ 6336-42-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6336-42-1 ]

[ 6336-42-1 ] Synthesis Path-Downstream   1~1

  • 1
  • C19H26B2O4S2 [ No CAS ]
  • C17H20BClO2S2 [ No CAS ]
  • [ 6336-42-1 ]
  • [ 56844-40-7 ]
  • 9-benzyl-6-(4-(2-(5-chloro-2-methylthiophen-3-yl)cyclopent-1-enyl)-5-methylthiophen-2-yl)-9H-purin-2-amine [ No CAS ]
  • 6-(4-(2-(5-chloro-2-methylthiophen-3-yl)cyclopent-1-en-1-yl)-5-methylthiophen-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one [ No CAS ]
  • 6-(4-(2-(5-(2-amino-9-benzyl-9H-purin-6-yl)-2-methylthiophen-3-yl)cyclopent-1-en-1-yl)-5-methylthiophen-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one [ No CAS ]
  • 6,6'-(4,4'-(cyclopentene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))bis(9-benzyl-9H-purin-2-amine) [ No CAS ]
  • 6,6'-(4,4'-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))bis(thieno[2,3-d]pyrimidin-4(3H)-one) [ No CAS ]
YieldReaction ConditionsOperation in experiment
18.3%; 15.9%; 11%; 12.2%; 12.2% Compound IV (1.00 m mol, 0.23 g) mixing with compound V (1.00 mmol, 0.26 g) was dissolved in 1,4-dioxane (15 mL), then Pd(PPh3)4 (0.05 mmol, 58 mg) and aqueous Na2CO3 (5 mL, 2 M) were added. This two-phase system was heated in an oil bath at a temperature of 60 C and the solution of II and III was added dropwise via a syringe in a short time. The reaction was then stirredat 110 C for 24 h and cooled to room temperature, after which H2O (50 mL) were added and extracted with EtOAc (3 x 50 mL). The combined organic fractions were dried over Na2SO4 and the solvent was removed by evaporation under vacuum. The residue was purified with column chromatography on silica gel. The product was separated by means of gradient elution (DCM/EtOH, v/v) to give five pure products with moderate overall yields.
 

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