Home Cart Sign in  
Chemical Structure| 634605-30-4 Chemical Structure| 634605-30-4

Structure of 634605-30-4

Chemical Structure| 634605-30-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 634605-30-4 ]

CAS No. :634605-30-4
Formula : C7H13NO
M.W : 127.18
SMILES Code : CN(CCC#C)CCO

Safety of [ 634605-30-4 ]

Application In Synthesis of [ 634605-30-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 634605-30-4 ]

[ 634605-30-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 634605-30-4 ]
  • [ 18372-22-0 ]
  • [ 634605-31-5 ]
YieldReaction ConditionsOperation in experiment
56% With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20℃; for 1h; 3-BUTYNYL P-TOSYLATE Compound 2a (0.90 g, 4.0 MMOL) and 2-METHYLAMINOETHANOL (0.30 g, 4.0 mmol) were dissolved in DMF (2 mL) and sodium bicarbonate (0.34 g, 4.0 MMOL) was added. The mixture was heated to 75 C under argon for 2 h then cooled to rt and partitioned between DCM (30 mL) and saturated sodium bicarbonate (15 mL). The organic layer was washed once with sodium bicarbonate (15 mL), once with brine (10 mL), then dried (NA2SO4) and evaporated in vacuo to give Compound 2b as a colorless oil (0.98 g). Compound 2b was added to Compound 1b (0.43 g, 2.1 MMOL) followed by triphenyl phosphine (0.73 g, 2.8 MMOL) in THF (15 mL) and DIETHYLAZODICARBOXYLATE (0.49 g, 2.8 MMOL) and the mixture was stirred at ambient temperature for 1 h. The product was evaporated in vacuo to an oil, which was purified via flash column chromatography (ethyl acetate) to give Compound 2c (0.37 g, 56%) as a tan solid. ES-MS m/z 313 (MH+). A portion of the indole Compound 2c (34 mg, 0.11 MMOL) and 1-naphthalene acetamide (Compound 2d, 18 mg, 0.11 MMOL) in THF (1 mL) were treated with 1 M potassium t-butoxide in THF (0.33 mL, 0.33 MMOL) while being cooled in an ice bath. The mixture was stirred at ambient temperature for 3 h, then treated with 12 N HCI (0.15 mL), stirred for 10 min and evaporated in vacuo to give an oil. The oil was partitioned between chloroform and saturated sodium bicarbonate. The organic layer was washed again with saturated sodium bicarbonate, once with brine, then dried (NA2SO4) and evaporated in vacuo to give a mixture of Compound 17 and Compound 18 (50 mg) as an orange oil. The material was purified by preparative TLC to separate Compound 17 and Compound 18. Compound 17 : H NMR (CDCI3) 5 1.81 (s, 3 H), 2.31 (s, 3H), 2.81 (m, 2H), 3.30 (BD S, 2H), 4.22 (m, 2H), 6.18 (d, J=8. 0HZ, 1H), 6.52 (m, 1 H), 7.0 (m, 1 H), 7.15-8. 0 (m, 8H), 8.07 (s, 1 H) ; ES-MS M/Z 448 (MH+). Compound 18: 1H NMR (CDCI3) 61. 97 (m, 1 H), 2.24 (m, 2H), 2.29 (s, 3H), 2.61 (t, J = 7.3 Hz, 2H), 2.77 (m, 2H), 4.19 (m, 2H), 6.18 (d, J = 8.2 Hz, 1H), 6.51 (m, 1 H), 7.0 (m, 1 H), 7.20-7. 93 (m, 8H), 8.04 (s, 1 H) ; ES-MS M/Z 448 (MH+).
 

Historical Records