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Chemical Structure| 63529-30-6 Chemical Structure| 63529-30-6

Structure of 63529-30-6

Chemical Structure| 63529-30-6

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Product Details of [ 63529-30-6 ]

CAS No. :63529-30-6
Formula : C8H5BrClFO
M.W : 251.48
SMILES Code : FC1=CC=C(C(CBr)=O)C=C1Cl
MDL No. :MFCD05154991
InChI Key :JOCPGHGWUUBURW-UHFFFAOYSA-N
Pubchem ID :2782785

Safety of [ 63529-30-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P261-P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 63529-30-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 63529-30-6 ]

[ 63529-30-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2923-66-2 ]
  • [ 63529-30-6 ]
YieldReaction ConditionsOperation in experiment
With bromine; In 1,4-dioxane; diethyl ether; at 0℃; for 4h; Example 1A 2-Bromo-<strong>[2923-66-2]1-(3-chloro-4-fluorophenyl)ethanone</strong> At 0 C., 1.00 g (5.79 mmol) of <strong>[2923-66-2]3-chloro-4-fluoroacetophenone</strong> is provided in 20 ml of a 1:1 mixture of 1,4-dioxane and diethyl ether, a solution of 0.30 ml (5.79 mmol) of bromine in 10 ml of a 1:1 mixture of 1,4-dioxane and diethyl ether is added dropwise with exclusion of light and the mixture is stirred for 4 hours. Water and dichloromethane are subsequently added, the phases are separated, the aqueous phase is extracted with dichloromethane and, the combined organic phases are dried over sodium sulfate, filtered and concentrated. 1.35 g (63% of theory) of the title compound having a purity of 68% are obtained which are reacted without further purification. 1H-NMR (400 MHz, DMSO-d6): delta=8.23 (dd, 1H), 8.04 (ddd, 1H), 7.63 (t, 1H), 4.97 (s, 2H). GC-MS (Method 11): Rt=5.22 min; MS (EIpos): m/z=252 [M]+.
 

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