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Chemical Structure| 63853-74-7 Chemical Structure| 63853-74-7

Structure of 63853-74-7

Chemical Structure| 63853-74-7

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Product Details of [ 63853-74-7 ]

CAS No. :63853-74-7
Formula : C5H9NO2
M.W : 115.13
SMILES Code : O=C1NC(OC)CC1
MDL No. :MFCD00192270

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Application In Synthesis of [ 63853-74-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 63853-74-7 ]

[ 63853-74-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 63853-74-7 ]
  • [ 3032-81-3 ]
  • N-(3,5-dichlorophenyl)-5-methoxypyrrolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
68% With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 60℃; for 24h;Inert atmosphere; General procedure: A suspension of DL-5-methoxypyrrolidin-2-one (3a) or arylaminopyrrolidinones 3b,c (1 equiv), CuI (0.5 equiv), cesium carbonate (2 equiv), and corresponding aryl iodide (1 equiv) in dioxane was placed under a nitrogen atmosphere. The coupling ligand DMEDA (1 equiv) was added dropwise by using a syringe and the mixture was then stirred at 60 °C for various periods of time (14?88 h). At the end ofthe reaction, the insoluble salts deposited after cooling at r.t. were collected by filtration then washed with dichloromethane. The resulting filtrate was concentrated in vacuo and the residue was partitioned between water and dichloromethane. The organic layer was dried on MgSO4 and evaporated to dryness. The residue was finally purified by chromatography on silica gel column (EtOAc/n-heptane) to afford pure N-arylated compound 40?44.
  • 2
  • [ 63853-74-7 ]
  • [ 1065181-58-9 ]
  • ethyl 5-bromo-3-(5-oxopyrrolidin-2-yl)-1H-indole-7-carboxylate [ No CAS ]
 

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