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[ CAS No. 639520-70-0 ]

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Chemical Structure| 639520-70-0
Chemical Structure| 639520-70-0
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Product Details of [ 639520-70-0 ]

CAS No. :639520-70-0 MDL No. :MFCD12913712
Formula : C12H16BrNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :286.16 g/mol Pubchem ID :-
Synonyms :

Safety of [ 639520-70-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 639520-70-0 ]

  • Downstream synthetic route of [ 639520-70-0 ]

[ 639520-70-0 ] Synthesis Path-Downstream   1~14

  • 1
  • [ 201230-82-2 ]
  • [ 6638-79-5 ]
  • [ 639520-70-0 ]
  • tert-butyl N-methyl-N-(4-N-methoxy-N-methylbenzamide)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% With sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 80℃; for 13h;
95% With palladium diacetate; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 80℃; for 13h;
  • 2
  • [ 131818-17-2 ]
  • [ 74-88-4 ]
  • [ 639520-70-0 ]
YieldReaction ConditionsOperation in experiment
5.0 mmol of 4-bromoaniline (0.86 g) is dissolved in 10 mL [OF THF ;] 1.09 g (5.0 mmol) of di-tert-butyl dicarbonate is added, and the resultant solution is warmed to [50 C FOR] 5 hours. The reaction is partitioned between water and ethyl acetate; the organic layer is washed with brine, dried over [NA2S04,] and and concentrated to give a white solid. This crude material is dissolved in 20 mL of dry THF and cooled in an ice [BATH ;] and 250 mg (1.25 eq) of NaH (60% oil dispersion) is added portionwise. Gas evolves, leaving a foamy semisolid after 15 min. Additional THF (10 mL) is added to break up the foam, followed by 0. [50] mL (1.6 eq) of [IODOMETHANE.] The resultant mixture is stirred overnight, warming slowly to ambient temperature. The reaction mixture is added carefully to aqueous IN [H3P04] (some gas evolves.), the resulting mixture is extracted with ethyl acetate. The organic layer is washed with brine and dried over [NA2S04.] The crude product is purified by silica gel chromatography, eluting with a gradient [OF 0->10%] ethyl [ACETATE/HEXANES,] providing 1.08 g (76% overall) of the title compound as a slightly yellowish oil.
With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20℃; for 18h; 0.263 mL (1.1 eq. ) iodomethane are added dropwise at room temperature to a stirred suspension of 1.1 g (4 mmol) (4-bromo-phenyl)-carbamic acid tert-butyl ester and 2 g (1.6 eq. ) cesium carbonate in 15 mL DMF. After stirring for an additional18 hours, the reaction mixture is extracted with WATER/ETHYL acetate and the combined organic phases are washed with brine, dried over magnesium sulfate and evaporated to yield the desired product as a colorless oil, which is used without further purification.
  • 3
  • [ 84371-57-3 ]
  • [ 639520-70-0 ]
  • [ 639520-75-5 ]
YieldReaction ConditionsOperation in experiment
90% Stage #1: 4-(N-tert-butyloxycarbonyl-N-methylamino)phenyl bromide With iodine; magnesium In tetrahydrofuran at 20℃; for 0.416667h; Heating / reflux; Stage #2: With copper(l) iodide In tetrahydrofuran at 0℃; for 0.0333333h; Stage #3: (5'R,8'S,10'R,13'S,14'S,17'S)-13'-methyl-17'-(prop-1-yn-1-yl)-1',2',7',8',12',13',14',15',16',17'-decahydro-4'H,6'H-spiro[[1,3]dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-ol With ammonium chloride more than 3 stages; 1G Example [1G]l; tert-butyl 4-((5R,11R,13S,17S)-5,17-dihydroxy-13-methy1-17-prop-1-yny1- [1, 2, 4, 5, 6, 7, 8, 11,] 12,13, 14,15, 16,17-tetradecahydrospiro [[CYCLOPENTALALPHENANTHRENE-3,] 2'- [RL,] [33LDIOXOLAN]-YL)] phenyl (methyl) carbamate A 50 mL flask charged with Mg powder (44 mg, 1.8 mmol) was dried with heat-gun under N2. After the apparatus was cooled to room temperature, THF (2 mL) and a small [CRYSTE] of iodine were added. To the efficiently stirred mixture was added 0.6 mL of a solution of the compound of Example 1D (500 mg, 1.75 mmol) in THF (2 mL). After the mixture was heated to reflux for about 5 minutes, the iodine color quickly faded to colorless and then the mixture was cooled to room temperature. The remainder of the bromide solution was added dropwise over 20 minutes. The mixture was cooled in an ice-water bath for 30 minutes and then CuI (132 mg, 0.69 mmol, powder) was added in one portion. After the mixture was stirred for 2 minutes, a solution of the compound of Example 1F (256 mg, 0.69 mmol) in THF (2 [ML)] was added, causing the formation of a voluminous light yellow precipitate. After 30 minutes, [NH4C1] (5 mL, sat) solution was slowly added, followed by EtOAc (10 mL). After the mixture was stirred for 10 minutes, the aqueous layer was separated and extracted with EtOAc. The combined organic layer was washed with brine (3x), dried over [NA2S04] and concentrated. The crude product was purified by HPLC (normal phase) to provide the title compound (352 mg, 90% yield).
  • 4
  • [ 639520-95-9 ]
  • [ 639520-70-0 ]
  • [ 639520-97-1 ]
YieldReaction ConditionsOperation in experiment
34% Stage #1: 4-(N-tert-butyloxycarbonyl-N-methylamino)phenyl bromide With magnesium In tetrahydrofuran Heating / reflux; Stage #2: With copper(l) iodide In tetrahydrofuran at 0℃; for 0.0333333h; Stage #3: (5'R,10'R,13'S,16'R,17'S)-13',16'-dimethyl-17'-prop-1-ynyl-1',2',7',8',12',13',14',15',17'-nonahydro-6'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-ol With sodium hydrogencarbonate; ammonium chloride; toluene-4-sulfonic acid more than 3 stages; 4C [(11] ß, 16a, [17A)-17-HYDROXY-16-METHYL-11- (4- (METHYLAMINO)] phenyl) -17-prop-1-ynylestra-4,9- dien-3-one Rieke Mg (1.0 M in THF, 13 mL) was added to a flame-dried three-necked round- bottom flask (fitted with a reflux condenser, glass stopper and rubber septum) along with 20 mL THF. The compound described in Example 1D (1.86 g, 6.50 mmol) was then added dropwise. After the addition of a small portion of the bromide, the flask was heated with a heat gun until the reaction initiated. The remaining bromide was added in portions, allowing for the reaction mixture to come to reflux and then cool. Upon completion of addition, the reaction solution cooled to room temperature and then was cooled in an ice bath. CuI (1.23, 6.50 mmol) was added in one portion. After 2 minutes, a solution of the compound described in Example 4B (1.0 g, 2.6 mmol) in 6 mL THF was added rapidly. After stirring at [0 °C] for 1 hour, the reaction was quenched with aqueous [NH4C1] and extracted with ethyl acetate. The organic extracts were washed with brine, dried [(MGS04)] and concentrated. The crude residue was dissolved in 7.6 mL THF and 6 [ML] [CH2C12.] To that solution was added TsOH (3.8 g, 19.9 mmol) and the resulting solution was stirred at room temperature for 3 h. Sat. aq. [NAHCO3] was added to neutralize the reaction and the resulting solution was extracted with ethyl acetate. The organic extracts were washed with brine, dried [(MGS04)] concentrated and purified by column chromatography (70: 30 hexanes: ethyl acetate). The title compound was isolated in 34% yield (250 mg).
  • 5
  • [ 67-56-1 ]
  • [ 201230-82-2 ]
  • [ 639520-70-0 ]
  • [ 741275-29-6 ]
YieldReaction ConditionsOperation in experiment
86% With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene at 70℃; for 24h;
  • 7
  • 4-((1-(N,N-dimethylsulfamoyl)-1H-imidazol-4-yl)methyl)-piperidine [ No CAS ]
  • [ 639520-70-0 ]
  • N,N-dimethyl-4-((1-(4-(N-Boc,N-methylamino)phenyl)-piperidin-4-yl)methyl)-1H-imidazole-1-sulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% Stage #1: 4-((1-(N,N-dimethylsulfamoyl)-1H-imidazol-4-yl)methyl)-piperidine; 4-(N-tert-butyloxycarbonyl-N-methylamino)phenyl bromide With di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I) In toluene for 2h; Reflux; Stage #2: With water In toluene
  • 8
  • [ 111-42-2 ]
  • [ 639520-70-0 ]
  • [ 1280078-67-2 ]
YieldReaction ConditionsOperation in experiment
62% Stage #1: 4-(N-tert-butyloxycarbonyl-N-methylamino)phenyl bromide With n-butyllithium In tetrahydrofuran at -78℃; for 0.166667h; Inert atmosphere; Stage #2: With Triisopropyl borate In tetrahydrofuran at -78 - 20℃; for 1h; Stage #3: 2,2'-iminobis[ethanol] In diethyl ether; isopropyl alcohol Typical experimental procedure for the synthesis of aryl dioxazaborocane General procedure: To 1 equiv of bromoaryl in THF (1 mmol/mL) under Argon at -78 °C is added dropwisely 1 equiv of n-BuLi. After 10 min at -78 °C neat B(O-iPr)3 is dropwisely added. The resulting mixture is stirred for 1 h while allowed to warm to room temperature. Diethyl ether and a saturated solution of ammonium chloride are then added, and the resulting mixture is stirred for 30 min. The organic and aqueous phases are separated, the aqueous phase is then extracted with ether, and the organic phases are washed with brine. The organic phase is dried over MgSO4 and filtered. The diethanolamine solution (i-PrOH, 3 M, 1 equiv) is added under stirring. A solid precipitates instantly. The mixture is filtered, and the solid is washed with ether and dried under vacuum.
  • 9
  • [ 639520-70-0 ]
  • [ 1280078-95-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 - 20 °C 2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; triphenylphosphine / water; N,N-dimethyl-formamide / 100 °C / Inert atmosphere
  • 10
  • [ 639520-70-0 ]
  • [ 1280078-97-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 - 20 °C 2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; triphenylphosphine / water; N,N-dimethyl-formamide / 100 °C / Inert atmosphere
  • 11
  • [ 639520-70-0 ]
  • [ 1280079-00-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 - 20 °C 2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; triphenylphosphine / water; N,N-dimethyl-formamide / 100 °C / Inert atmosphere
  • 12
  • [ 24424-99-5 ]
  • [ 6911-87-1 ]
  • [ 639520-70-0 ]
YieldReaction ConditionsOperation in experiment
95% In ethanol at 20℃; for 70h;
38% With dmap; triethanolamine In dichloromethane at 20℃; for 16h;
In tetrahydrofuran at 80℃; for 12h; 4 Compound 16 (1 g, 5.43 mmol) was dissolved in THF and Boc anhydride (2.36 g, 10.86 mmol) was added. The mixture was refluxed at 80° C. for 12 hours and then concentrated under reduced pressure. The mixture was chromatographed (Hexane:Ethyl acetate = 9:1) to synthesize compound 17.
  • 13
  • [ 32857-49-1 ]
  • [ 639520-70-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: potassium diphenylphosphine / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: sodium hydroxide / tetrahydrofuran; water / 12 h / Inert atmosphere
  • 14
  • [ 24424-99-5 ]
  • [ 84250-73-7 ]
  • [ 639520-70-0 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide In tetrahydrofuran; water for 12h; Inert atmosphere;
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