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Chemical Structure| 642443-45-6 Chemical Structure| 642443-45-6

Structure of 642443-45-6

Chemical Structure| 642443-45-6

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Product Details of [ 642443-45-6 ]

CAS No. :642443-45-6
Formula : C13H23ClN2O3
M.W : 290.79
SMILES Code : O=C(N1CC(CNC(CCl)=O)CCC1)OC(C)(C)C
MDL No. :MFCD21093038

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Application In Synthesis of [ 642443-45-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 642443-45-6 ]

[ 642443-45-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 79-04-9 ]
  • [ 162167-97-7 ]
  • [ 642443-45-6 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -10 - 0℃; 3-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester 1c (5.0 g, 23.4 mmol) in 20 mL CH2Cl2 was added dropwise to a cold (-10-->0° C.) solution of chloroacetylchloride (2.8 mL, 35 mmol, 1.5 equiv) and diisopropylethylamine (6.1 mL, 35 mmol, 1.5 equiv) in 60 mL CH2Cl2 under N2. After being left overnight (-10° C.-->rt), the mixture was diluted with ethyl acetate and washed briefly with water and brine, dried (Na2SO4), and concentrated to give 3-[(2-chloroacetylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 1d as a dark brown oil. The crude product was used without further purification.
 

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