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[ CAS No. 64398-84-1 ] {[proInfo.proName]}

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Chemical Structure| 64398-84-1
Chemical Structure| 64398-84-1
Structure of 64398-84-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 64398-84-1 ]

CAS No. :64398-84-1 MDL No. :MFCD00085575
Formula : C10H7N3O3S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 249.25 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 64398-84-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 64398-84-1 ]

[ 64398-84-1 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 121-66-4 ]
  • [ 98-88-4 ]
  • [ 64398-84-1 ]
YieldReaction ConditionsOperation in experiment
87% With triethylamine In dichloromethane at 20℃; 2 General method of synthesis of amides (9-12) General procedure: To a solution of 2-amino-5-nitrothiazole (0.3 g, 0.0020 mol) in dichloromethane was added 1.2 molar equiv of triethylamine (TEA). After the reaction mixture was stirred at 5 °C for 15 min, acetic anhydride (0.0100 mol, 5 equiv), or respectively acyl chlorides (0.0022 mol, 1.1 equiv) were added drop-wise. The reaction mixture was stirred at room temperature for 4-24 h. After complete conversion, the solvent was removed in vacuo and the residue was neutralized with saturated NaHCO3 solution. The precipitated solids were recrystallized from a mixture of solvents.
81% With triethylamine In tetrahydrofuran at -15 - 20℃; Reflux; 2.b General procedure: (b) 2-Amino-5-nitrothiazole (1.5 mmol, 1.0 equiv) was dissolved in dry tetrahydrofuran (5 mL/mmol), and triethylamine (1.8 mmol, 1.2 equiv) was added to the reaction solution. At -15°C, the benzoyl chloride solution prepared in step (a) was added dropwise to the above precooled reaction solution. The reaction solution was returned to room temperature, heated to reflux overnight, reacted until the starting material was completely consumed, and the reaction was quenched by adding water. The reaction solution was extracted with ethyl acetate, the combined organic phases were washed with dilute hydrochloric acid and saturated brine, dried over anhydrous sodium sulfate, filtered, and distilled under reduced pressure to obtain the crude product. The crude product was purified by column chromatography (dichloromethane/methanol gradient elution) to give the title compound.
42% With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -78 - 20℃; for 24h; Inert atmosphere;
4.6% With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h;
With triethylamine In tetrahydrofuran at -15℃; Reflux;

  • 2
  • [ 5468-77-9 ]
  • [ 64398-84-1 ]
  • [ 38922-45-1 ]
  • [ 38922-31-5 ]
YieldReaction ConditionsOperation in experiment
With sodium hydride; N,N-dimethyl-formamide
  • 3
  • [ 59721-11-8 ]
  • [ 64398-84-1 ]
  • [ 38922-45-1 ]
  • [ 38922-49-5 ]
YieldReaction ConditionsOperation in experiment
With sodium hydride; N,N-dimethyl-formamide
YieldReaction ConditionsOperation in experiment
/BRN= 188280/;
  • 5
  • [ 65-85-0 ]
  • [ 64398-84-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: thionyl chloride; pyridine / dichloromethane / Reflux 2: triethylamine / tetrahydrofuran / -15 °C / Reflux
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