Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 644-08-6 | MDL No. : | MFCD00008544 |
Formula : | C13H12 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ZZLCFHIKESPLTH-UHFFFAOYSA-N |
M.W : | 168.23 | Pubchem ID : | 12566 |
Synonyms : |
4-Phenyltoluene
|
Num. heavy atoms : | 13 |
Num. arom. heavy atoms : | 12 |
Fraction Csp3 : | 0.08 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 0.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 56.84 |
TPSA : | 0.0 Ų |
GI absorption : | Low |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | Yes |
CYP2C9 inhibitor : | Yes |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -4.04 cm/s |
Log Po/w (iLOGP) : | 2.51 |
Log Po/w (XLOGP3) : | 4.63 |
Log Po/w (WLOGP) : | 3.66 |
Log Po/w (MLOGP) : | 5.06 |
Log Po/w (SILICOS-IT) : | 4.08 |
Consensus Log Po/w : | 3.99 |
Lipinski : | 1.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 2.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -4.42 |
Solubility : | 0.00644 mg/ml ; 0.0000383 mol/l |
Class : | Moderately soluble |
Log S (Ali) : | -4.36 |
Solubility : | 0.00742 mg/ml ; 0.0000441 mol/l |
Class : | Moderately soluble |
Log S (SILICOS-IT) : | -5.29 |
Solubility : | 0.000855 mg/ml ; 0.00000508 mol/l |
Class : | Moderately soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 2.0 |
Synthetic accessibility : | 1.21 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; toluene; at 80℃;Inert atmosphere; | General procedure: To a stirred solution of the appropriately substituted toluene in CCl4 (10 mL per mmol) were added 0.95 eq. of NBS and AIBN (5 mg per mmol). The reaction mixture was refluxed at 80 C and then cooled to room temperature. The product was diluted with water and extracted with EtOAc. The organic layers were dried with MgSO4, filtered, and concentrated. Purification was performed by column chromatography using a mixture of CH/EtOAc (6:1). The compounds were used, without structure determination, directly for the next step. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; | a 4-(Bromomethyl)biphenyl A mixture of 4-phenyltoluene (4.83 g, 28.7 mmol), N-bromosuccinimide (5.64 g, 31.7 mmol), benzoyl peroxide (catalytic), and anhydrous carbon tetrachloride (35 mL) was refluxed for 24 hours. The mixture was cooled to room temperature and filtered to give a mixture (7.32 g) of 4-(dibromomethyl)biphenyl, 4-(bromomethyl)biphenyl, and 4-phenyltoluene (14:82:4 molar ratio by 1H-NMR). The product was used without further purification in the next step. 1H-NMR of the title compound (300 MHz, CDCl3) delta7.56-7.60 (m, 4H), 7.33-7.48 (m, 5H), 4.55 (s, 2H). Partial 1H-NMR of 4-(dibromomethyl)biphenyl (300 MHz, CDCl3) delta6.71 (s, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
25%Spectr.; 10%Spectr. | With sodium hydroxide; In water; at 80℃; for 3h; | To a screw-capped vial with a stirring bar were added 4-bromotoluene(86.4 mg, 0.5 mmol), phenyltrimethoxysilane (152 mg,0.75 mmol), PS-PdONPs (2.9 mg, 1.5 mol% of Pd), TBAC (142 mg,0.5 mmol), and aq NaOH solution (1.5 M, 1 mL). After stirring at80 C for 3 h, the reaction mixture was cooled to r.t. by immediatelyimmersing the vial in H2O (ca. 20 C) for about 10 min.After separating the catalyst and the aqueous phase by centrifugation,the aqueous phase was decanted. The recovered catalystwas washed with H2O (5 × 3.0 mL) and Et2O (5 × 3.0 mL), whichwere then added to the aqueous phase. The aqueous phase wasextracted eight times with Et2O. The combined organic extractswere dried over MgSO4 and concentrated under reduced pressure.The product was analyzed by 1H NMR. The recovered catalystwas dried in vacuo and reused. Furthermore, the amount ofPd metal in the aqueous phase determined by ICP-AES analysiswas <0.1 ppm.4-Methylbiphenyl: 1H NMR (CDCl3): delta = 7.55-7.60 (m, 2 H),7.47-7.50 (m, 2 H), 7.39-7.43 (m, 2 H), 7.29-7.33 (m, 1 H),7.20-7.25 (m, 2 H), 2.38 (s, 3 H). 13C NMR (CDCl3): delta = 141.1,138.3, 136.9, 129.4, 128.7, 128.7, 126.9, 21.1. CAS registrynumber: 644-08-6. |
With potassium tert-butylate; In glycerol; at 80℃;Schlenk technique; Inert atmosphere; | General procedure: In a Schlenk tube, substrate (0.5 mmol), silane (0.6 mmol), base (1.5 mmol) and decane (71 mg, 0.5 mmol) as internal standard were added to 1 mL of preformed palladium nanoparticles (total amount of palladium 0.01 mmol) under argon. The reaction mixture was heated at 80 C and stirred for the indicated time (3-24 h), and then cooled down to room temperature. The organic products were extracted from glycerol with dichloromethane (5 * 3 mL). The obtained products were previously described in the literature and their identification was carried out by comparison of their GC-MS data, 1H and 13C NMR spectra with the reported data (see Table S1 in the Supporting Information). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
25%; 73% | bis(1,5-cyclooctadiene)nickel (0); 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene; In tetrahydrofuran; tetradecyl(trihexyl)phosphonium decanoate; at -78 - 20℃; for 18h;Product distribution / selectivity; | 12. Kumada-Corriu cross-coupling reaction with Ni catalyst in phosphonium-based ionic liquid; [00064] A stock solution of 1.0 M PhMgBr in THF (5 mL, 5 mmol) was addedto cold IL 103 (5.0 mL) at -78 C. The reaction mixture warmed up to room temperature and the THF was removed in vacuo. To it toluene (0.5 mL) was added to reduce viscosity, followed by the addition of one equivalent (wrt PhMgBr) of 4-fluorotoluene, 4-chlorotoluene, 4-bromotoluene or 4-iodotoluene. To this solution, .05 mol percent of the complex bis[l,3-di(2',6'-diisopropylphenyl)imidazolin-2-ylidene]nickel (0), prepared in situ by the reaction of nickel dicyclooctadiene and the free Af-heterocyclic carbene in IL 103, was added. On addition of nickel dicyclooctadiene to JV-heterocyclic carbene a color change from pale yellow to dark green was observed. The reaction mixture was stirred for 18 hours at room temperature under nitrogen and then quenched with a few drops of methanol and extraction was carried out using dichloromethane and water. The dichloromethane layer was then dried using anhydrous magnesium sulphate and then analysed by GC-MS. Yields are tabulated in Chart 2 below. In all cases a small amount (< 2 %) of biphenyl was observed. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
22%; 74% | bis(1,5-cyclooctadiene)nickel (0); 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene; In tetrahydrofuran; tetradecyl(trihexyl)phosphonium decanoate; at -78 - 20℃; for 18h;Product distribution / selectivity; | 12. Kumada-Corriu cross-coupling reaction with Ni catalyst in phosphonium-based ionic liquid; [00064] A stock solution of 1.0 M PhMgBr in THF (5 mL, 5 mmol) was addedto cold IL 103 (5.0 mL) at -78 C. The reaction mixture warmed up to room temperature and the THF was removed in vacuo. To it toluene (0.5 mL) was added to reduce viscosity, followed by the addition of one equivalent (wrt PhMgBr) of 4-fluorotoluene, 4-chlorotoluene, 4-bromotoluene or 4-iodotoluene. To this solution, .05 mol percent of the complex bis[l,3-di(2',6'-diisopropylphenyl)imidazolin-2-ylidene]nickel (0), prepared in situ by the reaction of nickel dicyclooctadiene and the free Af-heterocyclic carbene in IL 103, was added. On addition of nickel dicyclooctadiene to JV-heterocyclic carbene a color change from pale yellow to dark green was observed. The reaction mixture was stirred for 18 hours at room temperature under nitrogen and then quenched with a few drops of methanol and extraction was carried out using dichloromethane and water. The dichloromethane layer was then dried using anhydrous magnesium sulphate and then analysed by GC-MS. Yields are tabulated in Chart 2 below. In all cases a small amount (< 2 %) of biphenyl was observed. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
palladium diacetate; In tetrahydrofuran; | EXAMPLE 26 General Procedure for Determining the Effect of Various Additives on the Preparation of 4-methylbiphenyl via Suzuki Coupling An oven dried resealable Schlenk tube was evacuated and backfilled with argon and charged with palladium acetate (2.2 mg, 0.01 mmol, 1.0 mol percent), 2-(di-tert-butylphosphino)biphenyl (4.5 mg, 0.015 mmol, 1.5 mol percent), phenylboron dihydroxide (183 mg, 1.5 mmol), additive (3.0 mmol), and 4-chlorotoluene (0.12 mL, 1.0 mmol). The tube was evacuated and backfilled with argon, and THF (2 mL) was added through a rubber septum. The reaction mixture was stirred at room temperature for 20 hours. The reaction mixture was then diluted with ethyl acetate (30 mL) and poured into a separatory funnel. The mixture was washed with 2.0M NaOH (20 mL), followed by brine (20 mL). The organic layer was submitted for GC analysis giving the results tabulated below. | |
palladium diacetate; In tetrahydrofuran; | Example 26 General Procedure for Determining the Effect of Various Additives on the Preparation of 4-methylbiphenyl via Suzuki Coupling An oven dried resealable Schlenk tube was evacuated and backfilled with argon and charged with palladium acetate (2.2 mg, 0.01 mmol, 1.0 mol percent), 2-(di-tert-butylphosphino)biphenyl (4.5 mg, 0.015 mmol, 1.5 mol percent), phenylboron dihydroxide (183 mg, 1.5 mmol), additive (3.0 mmol), and 4-chlorotoluene (0.12 mL, 1.0 mmol). The tube was evacuated and backfilled with argon, and THF (2 mL) was added through a rubber septum. The reaction mixture was stirred at room temperature for 20 hours. The reaction mixture was then diluted with ethyl acetate (30 mL) and poured into a separatory funnel. The mixture was washed with 2.0M NaOH (20 mL), followed by brine (20 mL). The organic layer was submitted for GC analysis giving the results tabulated below. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
158 mg (94%) | With potassium fluoride;palladium diacetate; In tetrahydrofuran; | EXAMPLE 29 Optimized synthesis of 4-methylbiphenyl utilizing KF An oven dried resealable Schlenk tube was evacuated and backfilled with argon and charged with palladium acetate (2.2 mg, 0.01 mmol, 1.0 mol percent), 2-(di-tert-butylphosphino)biphenyl (6.0 mg, 0.020 mmol, 2.0 mol percent), phenylboron dihydroxide (183 mg, 1.5 mmol), and potassium fluoride (174 mg, 3.0 mmol). The tube was evacuated and backfilled with argon, and THF (1 mL) and 4-chlorotoluene (0.12 mL, 1.0 mmol) were added through a rubber septum. The tube was sealed with a teflon screwcap, and the reaction mixture was stirred at room temperature until the starting aryl chloride had been completely consumed as judged by GC analysis. The reaction mixture was then diluted with ether (30 mL) and poured into a separatory funnel. The mixture was washed with 1.0 M NaOH (20 mL), and the aqueous layer was extracted with ether (20 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated. The crude material was purified by flash chromatography on silica gel to afford 158 mg (94percent) of the title compound. |
158 mg (94%) | With potassium fluoride;palladium diacetate; In tetrahydrofuran; | Example 29 Optimized Synthesis of 4-methylbiphenyl Utilizing KF An oven dried resealable Schlenk tube was evacuated and backfilled with argon and charged with palladium acetate (2.2 mg, 0.01 mmol, 1.0 mol percent), 2-(di-tert-butylphosphino)biphenyl (6.0 mg, 0.020 mmol, 2.0 mol percent), phenylboron dihydroxide (183 mg, 1.5 mmol), and potassium fluoride (174 mg, 3.0 mmol). The tube was evacuated and backfilled with argon, and THF (1 mL) and 4-chlorotoluene (0.12 mL, 1.0 mmol) were added through a rubber septum. The tube was sealed with a teflon screwcap, and the reaction mixture was stirred at room temperature until the starting aryl chloride had been completely consumed as judged by GC analysis. The reaction mixture was then diluted with ether (30 mL) and poured into a separatory funnel. The mixture was washed with 1.0 M NaOH (20 mL), and the aqueous layer was extracted with ether (20 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated. The crude material was purified by flash chromatography on silica gel to afford 158 mg (94percent) of the title compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
7%Spectr.; 13%Spectr. | With bis(acetylacetonate)nickel(II); n-butyllithium; In tetrahydrofuran; at 0 - 20℃; for 72h;Inert atmosphere; Schlenk technique; | General procedure: A flame-dried Schlenk tube, under an argon atmosphere, was charged with metal salt (0.05 mmol) and ligand(0.05 mmol). Dried and degazed THF (0.5 mL) was then added followed by the addition of n-BuLi (0.055 mmol). Themixture was stirred 10 min at room temperature and chlorobenzene (0.5 mmol) was added. After cooling the reactionvessel to 0C, the Grignard reagent (0.6 mmol) was added dropwise and the mixture was stirred at 60C (for Fe(acac)3)or room temperature (for Ni(acac)2). Aqueous saturated NH4Cl solution was then added and the aqueous layer wasextracted three times with pentane. The combined organic extracts were dried over MgSO4 and the solvent was removedunder vacuum. 1,2-dichloroethane was then added as internal reference to determine the NMR yield |
22%Spectr.; 6%Spectr. | With n-butyllithium; iron(III)-acetylacetonate; In tetrahydrofuran; at 0 - 60℃;Inert atmosphere; Schlenk technique; | General procedure: A flame-dried Schlenk tube, under an argon atmosphere, was charged with metal salt (0.05 mmol) and ligand(0.05 mmol). Dried and degazed THF (0.5 mL) was then added followed by the addition of n-BuLi (0.055 mmol). Themixture was stirred 10 min at room temperature and chlorobenzene (0.5 mmol) was added. After cooling the reactionvessel to 0C, the Grignard reagent (0.6 mmol) was added dropwise and the mixture was stirred at 60C (for Fe(acac)3)or room temperature (for Ni(acac)2). Aqueous saturated NH4Cl solution was then added and the aqueous layer wasextracted three times with pentane. The combined organic extracts were dried over MgSO4 and the solvent was removedunder vacuum. 1,2-dichloroethane was then added as internal reference to determine the NMR yield |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
10%; 85% | With trans-1,2-Diaminocyclohexane; potassium tert-butylate; silver(I) acetate; In dimethyl sulfoxide; at 150℃; for 13h;Inert atmosphere; | General procedure: To a stirred solution of boronic acid (1.2 mmol) and AgOAc (16 mg, 10 mol %) in dry DMSO (3 ml) was added aryl iodides/bromides (1 mmol) followed by trans-1,2-diaminocyclohexane (0.006 ml, 10 mol %) and KOtBu (224 mg, 2 equiv) under a nitrogen atmosphere. The mixture was heated to 150 C and the progress was monitored by TLC. After completion, the reaction mixture was washed with EtOAc-H2O and the organic phase was separated and dried over Na2SO4. The EtOAc was evaporated followed by flash column purification on silica gel to obtain the pure products. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
23%; 5%; 23% | With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In tetrahydrofuran; at 20℃; for 24h;Inert atmosphere; Schlenk technique; | General procedure: The arylcalcium iodide (2mmol) was dissolved in THF (20mL). Afterward, the chlorosubstituted arene (2mmol), solid [(dppp)NiCl2] (0.1mmol) as catalyst and mesitylene (100muL) as internal standard were added to the solution in that order. The resulting reaction mixture was stirred for 24h at ambient temperature. Thereafter, a sample of the solution was hydrolyzed with 2M hydrochloric acid (2mL) and extracted with n-heptane (1mL). The organic phase was analyzed by gas chromatography. |
10%; 12% | With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In tetrahydrofuran; at 20℃; for 24h;Inert atmosphere; Schlenk technique; | General procedure: The arylcalcium iodide (2mmol) was dissolved in THF (20mL). Afterward, the chlorosubstituted arene (2mmol), solid [(dppp)NiCl2] (0.1mmol) as catalyst and mesitylene (100muL) as internal standard were added to the solution in that order. The resulting reaction mixture was stirred for 24h at ambient temperature. Thereafter, a sample of the solution was hydrolyzed with 2M hydrochloric acid (2mL) and extracted with n-heptane (1mL). The organic phase was analyzed by gas chromatography. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
7%; 21%; 32% | With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In tetrahydrofuran; at 20℃; for 24h;Inert atmosphere; Schlenk technique; | General procedure: The arylcalcium iodide (2mmol) was dissolved in THF (20mL). Afterward, the chlorosubstituted arene (2mmol), solid [(dppp)NiCl2] (0.1mmol) as catalyst and mesitylene (100muL) as internal standard were added to the solution in that order. The resulting reaction mixture was stirred for 24h at ambient temperature. Thereafter, a sample of the solution was hydrolyzed with 2M hydrochloric acid (2mL) and extracted with n-heptane (1mL). The organic phase was analyzed by gas chromatography. |
Tags: 644-08-6 synthesis path| 644-08-6 SDS| 644-08-6 COA| 644-08-6 purity| 644-08-6 application| 644-08-6 NMR| 644-08-6 COA| 644-08-6 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :