Alternatived Products of [ 7116-95-2 ]
Product Details of [ 7116-95-2 ]
CAS No. : | 7116-95-2 |
MDL No. : | MFCD00221718 |
Formula : |
C15H16
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
196.29
|
Pubchem ID : | - |
Synonyms : |
|
Application In Synthesis of [ 7116-95-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 7116-95-2 ]
- 1
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[ 7116-95-2 ]
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[ 606-80-4 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: AlCl3 / chlorobenzene
2: (oxidation) |
|
- 2
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[ 108-86-1 ]
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[ 17356-09-1 ]
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[ 7116-95-2 ]
Yield | Reaction Conditions | Operation in experiment |
99 %Chromat. |
Stage #1: bromobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Inert atmosphere;
Stage #2: With zinc(II) chloride In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;
Stage #3: 4-iodocumene With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In tetrahydrofuran; hexane at 60℃; for 2h; Inert atmosphere; |
|
Reference:
[1]Liu, Qiang; Lan, Yu; Liu, Jing; Li, Gang; Wu, Yun-Dong; Lei, Aiwen
[Journal of the American Chemical Society, 2009, vol. 131, # 29, p. 10201 - 10210]
- 3
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[ 17356-09-1 ]
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[ 71-43-2 ]
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[ 7116-95-2 ]
Yield | Reaction Conditions | Operation in experiment |
92% |
With potassium <i>tert</i>-butylate; N,N`-dimethylethylenediamine at 80℃; sealed tube; Inert atmosphere; |
|
78% |
With N-methyl-o-aminobenzyl alcohol; potassium <i>tert</i>-butylate at 100℃; for 24h; Sealed tube; |
|
75% |
With potassium <i>tert</i>-butylate; N-methyl-N-(4-methoxyphenyl)amine at 80℃; for 20h; Schlenk technique; Inert atmosphere; |
|
73% |
With iron(III) chloride; potassium <i>tert</i>-butylate; N,N`-dimethylethylenediamine at 20 - 80℃; Inert atmosphere; |
|
71.7 %Chromat. |
With potassium <i>tert</i>-butylate at 120℃; for 24h; Green chemistry; |
|
Reference:
[1]Liu, Wei; Cao, Hao; Zhang, Hua; Zhang, Heng; Chung, Kin Ho; He, Chuan; Wang, Haibo; Kwong, Fuk Yee; Lei, Aiwen
[Journal of the American Chemical Society, 2010, vol. 132, # 47, p. 16737 - 16740]
[2]Chen, Suqing; Chen, Wenjun; Chen, Yu; Liu, Zhenghui; Mu, Tiancheng; Wang, Peng; Yan, Zhenzhong
[RSC Advances, 2020, vol. 10, # 25, p. 14500 - 14509]
[3]Yang, Huan; Zhang, Li; Jiao, Lei
[Chemistry - A European Journal, 2017, vol. 23, # 1, p. 65 - 69]
[4]Liu, Wei; Cao, Hao; Lei, Aiwen
[Angewandte Chemie - International Edition, 2010, vol. 49, # 11, p. 2004 - 2008]
[5]Gao, Yongjun; Tang, Pei; Zhou, Hu; Zhang, Wei; Yang, Hanjun; Yan, Ning; Hu, Gang; Mei, Donghai; Wang, Jianguo; Ma, Ding
[Angewandte Chemie - International Edition, 2016, vol. 55, # 9, p. 3124 - 3128][Angew. Chem., 2016, vol. 128, # 9, p. 3176 - 3180,5]
- 4
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[ 1625-92-9 ]
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[ 92-52-4 ]
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[ 7116-95-2 ]
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[ 644-08-6 ]
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[ 5707-44-8 ]
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[ 37909-95-8 ]
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[ 10289-45-9 ]
- 5
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[ 92-69-3 ]
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[ 7116-95-2 ]
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[ 10289-45-9 ]
- 6
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[ 76996-40-2 ]
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[ 1068-55-9 ]
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[ 7116-95-2 ]
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[ 10289-45-9 ]
- 7
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[ 405201-85-6 ]
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[ 1068-55-9 ]
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[ 7116-95-2 ]
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[ 10289-45-9 ]
- 8
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[ 1068-55-9 ]
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[ 2051-62-9 ]
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[ 7116-95-2 ]
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[ 10289-45-9 ]
Yield | Reaction Conditions | Operation in experiment |
|
|
General procedure: A 0.94 M soln of MeMgBr in THF (1.59 mL, 1.5 mmol) was added to a mixture of FeF3 (5.7 mg, 0.050 mmol) and 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride (64.4 mg, 0.15 mmol) in THF (2.0 mL) at 0C; 1-chloro-4-methoxybenzene (143 mg, 1.0 mmol) and undecane were then added at r.t. The mixture was stirred at 80 C for 24 h. The mixture was cooled to r.t. and an aliquot of the mixture was filtered through a Florisil pad. The product yield was determined by GC analysis (92% yield) using undecane as an internal standard. 1-Methoxy-4-methylbenzene is volatile, hence isolation was performed for the large-scale experiment using starting aryl chloride (5.6 mmol). The crude product was purified by column chromatography (silica gel, pentane, Rf = 0.06) and subsequent GPC to obtain the title compound (78.7 mg, 11%) as a colorless oil. |
- 9
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[ 586-61-8 ]
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[ 98-80-6 ]
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[ 7116-95-2 ]
Yield | Reaction Conditions | Operation in experiment |
|
With C25H29FeI2N3OPd; sodium carbonate; In N,N-dimethyl-formamide; at 100℃; for 19h;Schlenk technique; Sealed tube; |
General procedure: 1.0 mmol of halobenzene, 1.0 mmol of phenyl boronic acid, andthe prescribed amount of catalyst (0.5percent mol) in 5 mL of DMF wereintroduced into a Schlenk tube in the open air. The tube wascharged with a magnetic stir bar and an equimolar amount of base(Na2CO3, 2 mmol), and sealed, then fully immersed in a 100 °Csilicon oil bath. After the prescribed reaction time, the mixture wascooled to room temperature. Water was added (20 mL). Whitesuspension was extracted with dichloromethane (3 x 50 mL). Theorganic phase was washed once again with water, separated and treated with anhydrous MgSO4, filtered and analyzed by gas chromatography(GC-MS). The results presented are the average of tworuns. |
- 10
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[ 3562-73-0 ]
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[ 7116-95-2 ]
- 11
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[ 92-66-0 ]
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5-isopropyl-1-aza-5-germabicyclo[3.3.3]undecane
[ No CAS ]
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[ 7116-95-2 ]
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[ 10289-45-9 ]