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[ CAS No. 64495-55-2 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 64495-55-2
Chemical Structure| 64495-55-2
Structure of 64495-55-2 *Storage: {[proInfo.prStorage]}

Quality Control of [ 64495-55-2 ]

Related Doc. of [ 64495-55-2 ]

SDS

Product Details of [ 64495-55-2 ]

CAS No. :64495-55-2MDL No. :MFCD11501896
Formula : C9H6N2O3 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :190.16Pubchem ID :-
Synonyms :

Computed Properties of [ 64495-55-2 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 64495-55-2 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 64495-55-2 ]

  • Downstream synthetic route of [ 64495-55-2 ]

[ 64495-55-2 ] Synthesis Path-Downstream   1~10

YieldReaction ConditionsOperation in experiment
99% With hydrogenchloride; In 1,4-dioxane; water; at 100℃; for 3h; General procedure: Over a solution of ethyl (E)-3-(2-amino-5-(trifluoromethyl)phenyl)acrylate (37 g, 142.73 mmol, 1.00 equiv) in dioxane (92.7 mL), HCl (12N, 28 mL) was added. The resulting solution was stirred for 3 h at 100 C and quenched by the addition of 200 mL of water. The solids were collected by filtration to afford the desired final product as a yellow solid in 89% yield.
99% With hydrogenchloride; In 1,4-dioxane; at 100℃; for 3h; General procedure: Over a solution of ethyl (E)-3-(2-amino-5-(trifluoromethyl)phenyl)acrylate (37 g, 142.73 mmol, 1.00 equiv) in dioxane (92.7 mL), HC1 (12N, 28 mL) was added. The resulting solution was stirred for 3 h at 100 C and quenched by the addition of 200 mL of water. The solids were collected by filtration to afford the desired final product as a yellow solid in 89% yield.
94% 46B. 6-Nitro-2-quinolone Compound 46A (210 mg, 0.90 mmol) was dissolved in MeOH (10 mL), K2CO3 was added, and the reaction was stirred at rt for 30 min. The reaction was then concentrated under reduced pressure and subsequently purified by silica gel flash chromatography eluding with 5-10% MeOH/CH2Cl2 (gradient) to give the title compound (162 mg, 94%) as a pink solid. LC/MS m/z 191 [M+H]+.
  • 2
  • [ 64495-55-2 ]
  • [ 917835-00-8 ]
  • 3
  • [ 64495-55-2 ]
  • tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(6-nitro-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate [ No CAS ]
  • 4
  • [ 64495-55-2 ]
  • tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(6-amino-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate [ No CAS ]
  • 5
  • [ 64495-55-2 ]
  • ethyl (2E)-3-(6-amino-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)prop-2-enoate [ No CAS ]
  • 6
  • [ 64495-55-2 ]
  • methyl 2-[(1-methyl-6-nitro-2-oxo-1,2-dihydroquinolin-3-yl)sulfanyl]acetate [ No CAS ]
  • 7
  • [ 64495-55-2 ]
  • ethyl (2E)-3-(1-methyl-6-nitro-2-oxo-1,2- dihydroquinolin-3-yl)prop-2-enoate [ No CAS ]
  • 8
  • [ 64495-55-2 ]
  • 3-bromo-1-methyl-6-nitro-1,2-dihydroquinolin-2-one [ No CAS ]
  • 9
  • [ 64495-55-2 ]
  • 2-{[6-({5-chloro-2-[cis-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl}amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl]sulfanyl}acetic acid [ No CAS ]
  • 10
  • [ 64495-55-2 ]
  • methyl 2-[(6-amino-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)sulfanyl]acetate [ No CAS ]
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