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Chemical Structure| 648421-91-4 Chemical Structure| 648421-91-4

Structure of 648421-91-4

Chemical Structure| 648421-91-4

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Product Details of [ 648421-91-4 ]

CAS No. :648421-91-4
Formula : C12H17N3O2
M.W : 235.28
SMILES Code : O=C1C(C(N2CCN(C)CC2)=O)=CC=C(C)N1
MDL No. :N/A

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Application In Synthesis of [ 648421-91-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 648421-91-4 ]

[ 648421-91-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-01-3 ]
  • [ 38116-61-9 ]
  • [ 648421-91-4 ]
YieldReaction ConditionsOperation in experiment
With trifluoroacetic acid; In water; acetonitrile; EXAMPLE 137 6-methyl-3-[(4-methyl-1-piperazinyl)carbonyl]-2-pyridinol The desired product was prepared by substituting <strong>[38116-61-9]2-hydroxy-6-methylnicotinic acid</strong> for 6-methylnicotinic and 1-methylpiperazine for 2-methylpyrrolidine in Example 1. After workup the crude compound was purified by HPLC on a C-18 column with a solvent system increasing in gradient over 50 minutes from 5% to 100% acetonitrile/water containing 0.01% TFA to provide the desired product as the trifluoroacetate salt. MS m/e 236 (M+H)+; 1H NMR (DMSO-d6) delta 2.19 (s, 3H), 2.20 (s, 3H), 2.31 (br d, 4H), 3.21 (br t, 2H), 3.54 (br t, 2H), 6.04 (dd, 1H), 7.36 (d, 1H).
 

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