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Chemical Structure| 65321-43-9 Chemical Structure| 65321-43-9

Structure of 65321-43-9

Chemical Structure| 65321-43-9

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Product Details of [ 65321-43-9 ]

CAS No. :65321-43-9
Formula : C12H16O5
M.W : 240.25
SMILES Code : O=CC1=CC(OC)=C(OCCOC)C(OC)=C1

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65321-43-9 ]

[ 65321-43-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 58929-72-9 ]
  • [ 134-96-3 ]
  • [ 65321-43-9 ]
YieldReaction ConditionsOperation in experiment
72% With caesium carbonate; In N,N-dimethyl-formamide; at 150℃; for 0.166667h;Microwave irradiation; Preparation of 4-(4-(2-methoxyethoxy)-3,5-dimethoxybenzyl)-7-ethoxyisoquinolin-8-ol hydrochloride 223,5-Dimethoxy-4-(2-methoxyethoxy)benzaldehvde ECO 331624-Hydroxy-3,5-dimethoxybenzaldehyde (500 mg, 2.75 mmol) was dissolved in DMF (8 mL) and Cs2CO3 (900 mg, 2.75 mmol, 1 eq) was added at 20C. 2-Bromoethyl- methyl ether (550 μΙ_, 5.8 mmol, 2.1 eq) was added and the reaction mixture was stirred at 150C for 10 min under microwave irradiation (150 W). After cooling, the reaction mixture was poured into water (150 mL) and extracted by Et2O (200 mL). The organic layer was washed with water (2x50 mL), brine (50 mL), dried over MgSO4, filtered and concentrated to dryness under reduced pressure to give an orange solid (595 mg). Purification by column chromatography (SiO2, eluent cyclohexane:EtOAc = 7:3) gave, after evaporation and drying, 3,5-dimethoxy-4-(2- methoxyethoxy)benzaldehyde ECO 33162 as an off-white solid (477 mg, 72% yield). ECO 33162MW: 240.25; Yield: 72%; Off-white solid; Mp (C): 66.2Rf. 0.7 (cyclohexane:EtOAc = 5:5).1H-NMR (CDCIs, δ): 3.43 (s, 3H, OCH3), 3.72 (t, 2H, J = 3.5 Hz, CH2), 3.93 (s, 6H, 2xOCH3), 4.23 (t, 2H, J = 4.77 Hz, CH2), 7.13 (s, 2H, 2xArH), 9.87 (s, 1 H, CHO). MS-ESI m/z (% rel. Int.): 241 .1 ([MH]+, 72), 183.0 (100).HPLC: Method A, detection UV 254 nm, RT = 4.21 min, peak area 98.0%. Preparation of 4-(4-(2-methoxyethoxy)-3,5-dimethoxybenzyl)-7-ethoxyisoquinolin-8-ol hydrochloride 22
 

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