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Chemical Structure| 65680-20-8 Chemical Structure| 65680-20-8

Structure of 65680-20-8

Chemical Structure| 65680-20-8

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Product Details of [ 65680-20-8 ]

CAS No. :65680-20-8
Formula : C9H11NS
M.W : 165.26
SMILES Code : S=C(N)CCC1=CC=CC=C1
MDL No. :MFCD03150864

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Application In Synthesis of [ 65680-20-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65680-20-8 ]

[ 65680-20-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 65680-20-8 ]
  • [ 33142-21-1 ]
  • 2-phenethyl-thiazole-5-carboxylic acid methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.036 g In N,N-dimethyl-formamide; at 90℃; for 48h; A solution of 3-phenylpropanethioamide (1.049 g, 6.35 mmol) and ethyl 2-chloro-3- oxopropanoate (392 jiL, 3.175 mmol) in DMF (6.4 mL) was heated at 95C for 48 hours. Afterthis time, the reaction mixture was cooled to 0C and cold water (10 mL) was added. The reaction mixture was adjusted to pH 8 by slow addition of solid sodium bicarbonate and extracted with Et20, washed with water, saturated aqueous NaCI solution, dried (sodium sulfate), filtered and concentrated under reduced pressure. This material was purified by column chromatography, eluting with EtOAc/cyclohexane (0-25%). The desired fractions werecombined and dried under reduced pressure then repurified by column chromatography (DCM/cyclohexane; 25-100%) to afford the title compound (0.036 g). LCMS method: Method 1, RT: 5.36 mm, Ml: 248 [M+1] 1H NMR (500 MHz, CDCI3) O 8.29 (5, 1H), 7.30 (t, 2H), 7.24-7.19 (m, 3H), 3.88 (5, 3H), 3.34 (dd, 2H), 3.13 (dd, 2H)
 

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