Home Cart 0 Sign in  
X

[ CAS No. 65873-72-5 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 65873-72-5
Chemical Structure| 65873-72-5
Chemical Structure| 65873-72-5
Structure of 65873-72-5 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 65873-72-5 ]

Related Doc. of [ 65873-72-5 ]

Alternatived Products of [ 65873-72-5 ]
Product Citations

Product Details of [ 65873-72-5 ]

CAS No. :65873-72-5 MDL No. :MFCD02683446
Formula : C7H7NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :CTAIEPPAOULMFY-UHFFFAOYSA-N
M.W : 137.14 Pubchem ID :3364576
Synonyms :
6-Methoxy-3-pyridinecarboxaldehyde
Chemical Name :6-Methoxynicotinaldehyde

Calculated chemistry of [ 65873-72-5 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.14
Num. rotatable bonds : 2
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 36.12
TPSA : 39.19 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.3 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.12
Log Po/w (XLOGP3) : 1.18
Log Po/w (WLOGP) : 0.9
Log Po/w (MLOGP) : -0.08
Log Po/w (SILICOS-IT) : 1.48
Consensus Log Po/w : 0.92

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.75
Solubility : 2.46 mg/ml ; 0.018 mol/l
Class : Very soluble
Log S (Ali) : -1.6
Solubility : 3.46 mg/ml ; 0.0252 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -2.07
Solubility : 1.16 mg/ml ; 0.00849 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.51

Safety of [ 65873-72-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 65873-72-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 65873-72-5 ]
  • Downstream synthetic route of [ 65873-72-5 ]

[ 65873-72-5 ] Synthesis Path-Upstream   1~25

  • 1
  • [ 1628-89-3 ]
  • [ 13472-85-0 ]
  • [ 65873-72-5 ]
YieldReaction ConditionsOperation in experiment
51% With bromine; sodium acetate In hexane; acetic acid a)
The 5-(2-methoxypyridine)carboxaldehyde was prepared as follows:
Bromine (0.99 ml) was added dropwise to a stirred suspension of sodium acetate (1.59 g) and 2-methoxypyridine (1.93 ml) in acetic acid (10 ml).
The reaction mixture was stirred at room temperature for 25 minutes, then at 80° C. for 2.5 h.
The mixture was then allowed to cool and poured into ice-water, neutralised with 2M sodium hydroxide and extracted with ether.
The combined extracts were dried (MgSO4), filtered and evaporated.
The crude product was purified by column chromatography on silica gel eluding with 5percent ethyl acetate in hexane to give 5-bromo-2-methoxypyridine as a colourless oil (1.75 g, 51percent).
MS (ES) 190, 188 (M+H)+.
1H NMR (CDCl3) 8.20 (1H, d), 7.63 (1H, dd), 6.65 (1H, d), 3.90 (3H, s).
Reference: [1] Patent: US2002/107252, 2002, A1,
  • 2
  • [ 65873-72-5 ]
  • [ 15871-85-9 ]
Reference: [1] Organic Letters, 2015, vol. 17, # 20, p. 5064 - 5067
  • 3
  • [ 65873-72-5 ]
  • [ 7757-83-7 ]
  • [ 66572-55-2 ]
Reference: [1] Patent: US6218393, 2001, B1,
  • 4
  • [ 13472-85-0 ]
  • [ 68-12-2 ]
  • [ 65873-72-5 ]
YieldReaction ConditionsOperation in experiment
94%
Stage #1: With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.5 h;
Stage #2: at -78 - 20℃; for 1.5 h;
N-Butyl lithium (50 mL, 2.5M in hexane) was added drop wise to a solution of 5-Bromo-2-methoxy-pyridine (22.4 g, 119.1 mMol) in dry tetrahydrofuran (240 mL) at -78 degrees.
After complete addition the solution was stirred at -78 for an additional ninety minutes at which time dimethylformamide (18.5 mL, 238.3 mMol) was added drop wise and the solution stirred for ninety more minutes at -78 and then allowed to warm to room temperature.
The mixture was then poured into saturated sodium bicarbonate solution (1000 mL) and extracted with diethyl ether (3*250mL).
The combined organics were dried with magnesium sulfate, filtered, and concentrated to dryness to yield 15.4 g (94percent yield) of 6-Methoxy-pyridine-3-carbaldehyde as a pale yellow solid. 1H NMR (DMSO-d6): δ=9.97 (s,1H), 8.77 (m, 1H), 8.12 (dd, 1H, J=8.6, 2.3 Hz), 6.99 (d, 1H, J=8.7 Hz), 3.97 (s, 3H). LC/MS (Method A), rt=0.25 mins., purity=92.8percent, calculated mass=137, [M+H]+=138. HPLC (Method C): rt=4.9 mins., purity=95.9percent at; 210-370 nm and 98.7percent at; 256 nm.
20%
Stage #1: With n-butyllithium In tetrahydrofuran at -78℃; for 0.5 h; Inert atmosphere
Stage #2: at -78℃; for 2 h;
A solution of 5-bromo-2-methoxypyridine SM 1(1.04 g, 5.5 mmol) in THF (20 mL) was added n-BuLi (5.5 mL, 5.5 mmol) at -78 °C under N2, stirred at -78 °C for 0.5 h. Then DMF (1.5mL) was added and stirred at -78 °C for 2 h. The reaction was quenched with water and extracted with EtOAc, dried and evaporated, purified by combiflash (petroleum ether: ethyl acetate = 1:1) to give compound 1 (150 mg, 20percent).
66.7 g
Stage #1: With n-butyllithium In tetrahydrofuran at -78℃; for 0.5 h;
Stage #2: at -78℃; for 1 h;
To a solution of 5-bromo-2-methoxy-pyridine (95.0 g, 0.51 mol) in THF (2.0 L) was addedn-BuLi (212 ml, 0.53 mol) at -78 °C slowly. After the mixture was stuffed at -78 °C for 0.5 hr, tothe reaction mixture was added anhydrous DMF (44.3 g, 0.61 mmol) slowly. The reaction mixture was stirred at -78 °C for another lhr and then the reaction was quenched with sat. aqueous solution of NH4C1. The resulting mixture was extracted with EA. The organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue waspurified by flash column to give 6-methoxypyridine-3-carbaldehyde (66.7 g) as a light yellow solid.
Reference: [1] Synthesis, 2012, vol. 44, # 5, p. 735 - 746
[2] Journal of medicinal chemistry, 2004, vol. 47, # 20, p. 4829 - 4837
[3] Patent: US2006/19965, 2006, A1, . Location in patent: Page/Page column 27
[4] Synthesis, 1994, # 1, p. 87 - 92
[5] Synlett, 2009, # 15, p. 2508 - 2512
[6] Chemistry - A European Journal, 2017, vol. 23, # 35, p. 8450 - 8456
[7] Patent: WO2016/44770, 2016, A1, . Location in patent: Page/Page column 741
[8] Journal of Organic Chemistry, 1990, vol. 55, # 1, p. 69 - 73
[9] Journal of the American Chemical Society, 1997, vol. 119, # 33, p. 7694 - 7701
[10] Journal of the American Chemical Society, 1999, vol. 121, # 19, p. 4722 - 4723
[11] Patent: WO2016/107832, 2016, A1, . Location in patent: Page/Page column 157
  • 5
  • [ 58584-63-7 ]
  • [ 65873-72-5 ]
YieldReaction ConditionsOperation in experiment
61% With Dess-Martin periodane In dichloromethane at 0 - 23℃; for 12 h; (B) To a stirred solution of (6-methoxypyridin-3-yl)methanol (9.3 g, 66.906 mmol, 1.0 eq) in DCM (300ml), DMP (42.55 g, 100.35 mmol, 1.5 eq) was added at 0°C. The mixture was allowed to warm to RT andstir for 12 h. Reaction progress was monitored by TLC. The RM was quenched with ice water (150 ml) and extracted with DCM (2x 200 ml). The organic layer was washed with brine solution (100 ml), dried (Na2SO4), filtered and concentrated to afford the crude product, which was purified by CC (silica gel, 25percent EtOAc in PE) to afford 6-methoxynicotinaldehyde (6 g, 61percent).
Reference: [1] Tetrahedron, 1992, vol. 48, # 8, p. 1457 - 1464
[2] Patent: WO2015/158427, 2015, A1, . Location in patent: Page/Page column 132
[3] Patent: EP1621537, 2006, A1, . Location in patent: Page/Page column 35
  • 6
  • [ 15871-85-9 ]
  • [ 563-41-7 ]
  • [ 65873-72-5 ]
YieldReaction ConditionsOperation in experiment
50% With formaldehyd; sodium acetate In hydrogenchloride; ethanol; water (a)
A mixture of 2-methoxy-5-cyanopyridine (61.26 g), semi-carbazide hydrochloride (76.4 g), sodium acetate (74.92 g), ethanol (1,300 ml) and water (400 ml) was hydrogenated at 344 kPa using Raney nickel catalyst (1.0 g).
The mixture was evaporated to a volume of 500 ml, water (1,000 ml) was added and the mixture was allowed to stand at 0° overnight.
The mixture was filtered and the solid was washed with water and dissolved in 10percent hydrochloric acid (1,000 ml).
Formaldehyde solution (36percent w/v, 450 ml) was added and the mixture was warmed for 15 minutes, allowed to cool and was added to a solution of sodium acetate (298.5 g) in water (900 ml).
This mixture was extracted with ether and the combined extracts were successively washed with aqueous potassium carbonate and water and were dried and evaporated to give 6-methoxypyridine-3-carboxaldehyde (31.5 g, 50percent), m.p. 48-49°.
50% With formaldehyd; sodium acetate In hydrogenchloride; ethanol; water (i)
A mixture of 2-methoxy-5-cyanopyridine (61.26 g), semicarbazide hydrochloride (76.4 g), sodium acetate (74.92 g), ethanol (1300 ml) and water (400 ml) was hydrogenated at 344 kPa using Raney nickel catalyst (1.0 g).
The mixture was evaporated to a volume of 500 ml, water (1000 ml) was added and the mixture was allowed to stand at 0° overnight.
The mixture was filtered and the solid was washed with water and dissolved in 10percent hydrochloric acid (1000 ml).
Formaldehyde solution (36percent w/v, 450 ml) was added and the mixture was warmed for 15 minutes, allowed to cool and was added to a solution of sodium acetate (298.5 g) in water (900 ml).
This mixture was extracted with ether (3*500 ml) and the combined extracts were successively washed with aqueous potassium carbonate and water and were dried and evaporated to give 6-methoxypyridine-3-carboxaldehyde (31.5 g, 50percent) m.p. 48°-49°.
Reference: [1] Patent: US4255428, 1981, A,
[2] Patent: US4234588, 1980, A,
  • 7
  • [ 13472-85-0 ]
  • [ 65873-72-5 ]
YieldReaction ConditionsOperation in experiment
81% With n-butyllithium In tetrahydrofuran; <i>N</i>-methyl-acetamide b)
5-Bromo-2-methoxypyridine (1.53 g) was stirred in dry tetrahydrofuran (35 ml) under argon at -78° C. Butyl lithium (6.6 ml, 1.6M solution) was added dropwise to the solution and stirring continued at -78° C. for 1.5 h.
Dimethylformamide (1.3 ml) was then added dropwise and stirring continued at -78° C. for a further 30 minutes before allowing to warm to room temperature.
The reaction mixture was poured into saturated aqueous sodium hydrogen carbonate and the aqueous phase was extracted with ether.
The combined extracts were dried (MgSO4), filtered and evaporated.
The residue was purified by column chromatography on silica gel to give 5-(2-methoxypyridine)carboxaldehyde as a white solid (0.91 g, 81percent).
1H NMR (CDCl3) 9.95 (1H, s), 8.63 (1H, d), 8.06 (1H, dd), 6.85 (1H, d), 4.04 (3H, s).
Reference: [1] Patent: US2002/107252, 2002, A1,
  • 8
  • [ 13472-85-0 ]
  • [ 65873-72-5 ]
Reference: [1] Patent: US2003/144329, 2003, A1,
[2] Patent: US2003/83357, 2003, A1,
[3] Patent: US6515003, 2003, B1,
[4] Patent: US5618821, 1997, A,
  • 9
  • [ 1628-89-3 ]
  • [ 13472-85-0 ]
  • [ 65873-72-5 ]
YieldReaction ConditionsOperation in experiment
51% With bromine; sodium acetate In hexane; acetic acid a)
The 5-(2-methoxypyridine)carboxaldehyde was prepared as follows:
Bromine (0.99 ml) was added dropwise to a stirred suspension of sodium acetate (1.59 g) and 2-methoxypyridine (1.93 ml) in acetic acid (10 ml).
The reaction mixture was stirred at room temperature for 25 minutes, then at 80° C. for 2.5 h.
The mixture was then allowed to cool and poured into ice-water, neutralised with 2M sodium hydroxide and extracted with ether.
The combined extracts were dried (MgSO4), filtered and evaporated.
The crude product was purified by column chromatography on silica gel eluding with 5percent ethyl acetate in hexane to give 5-bromo-2-methoxypyridine as a colourless oil (1.75 g, 51percent).
MS (ES) 190, 188 (M+H)+.
1H NMR (CDCl3) 8.20 (1H, d), 7.63 (1H, dd), 6.65 (1H, d), 3.90 (3H, s).
Reference: [1] Patent: US2002/107252, 2002, A1,
  • 10
  • [ 95652-83-8 ]
  • [ 65873-72-5 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 1, 1989, # 2, p. 283 - 287
[2] Patent: US4990622, 1991, A,
  • 11
  • [ 3099-50-1 ]
  • [ 7757-82-6 ]
  • [ 65873-72-5 ]
Reference: [1] Patent: US4990622, 1991, A,
  • 12
  • [ 624-28-2 ]
  • [ 65873-72-5 ]
Reference: [1] Journal of the American Chemical Society, 1997, vol. 119, # 33, p. 7694 - 7701
[2] Journal of Organic Chemistry, 1990, vol. 55, # 1, p. 69 - 73
  • 13
  • [ 13472-85-0 ]
  • [ 107-31-3 ]
  • [ 65873-72-5 ]
Reference: [1] Organic Letters, 2014, vol. 16, # 19, p. 4972 - 4975
  • 14
  • [ 13472-85-0 ]
  • [ 20461-86-3 ]
  • [ 65873-72-5 ]
Reference: [1] Angewandte Chemie - International Edition, 2017, vol. 56, # 6, p. 1500 - 1505[2] Angew. Chem., 2017, vol. 129, # 6, p. 1522 - 1527,6
  • 15
  • [ 15871-85-9 ]
  • [ 65873-72-5 ]
Reference: [1] European Journal of Medicinal Chemistry, 1993, vol. 28, # 7-8, p. 601 - 608
  • 16
  • [ 26218-80-4 ]
  • [ 65873-72-5 ]
Reference: [1] Tetrahedron, 1992, vol. 48, # 8, p. 1457 - 1464
[2] Patent: WO2015/158427, 2015, A1,
  • 17
  • [ 1628-89-3 ]
  • [ 65873-72-5 ]
Reference: [1] Synthesis, 2012, vol. 44, # 5, p. 735 - 746
[2] Chemistry - A European Journal, 2017, vol. 23, # 35, p. 8450 - 8456
  • 18
  • [ 59-67-6 ]
  • [ 65873-72-5 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 1, 1989, # 2, p. 283 - 287
[2] Journal of the Chemical Society, Perkin Transactions 1, 1989, # 2, p. 283 - 287
  • 19
  • [ 3099-50-1 ]
  • [ 65873-72-5 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 1, 1989, # 2, p. 283 - 287
[2] Journal of the Chemical Society, Perkin Transactions 1, 1989, # 2, p. 283 - 287
  • 20
  • [ 121643-49-0 ]
  • [ 65873-72-5 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 1, 1989, # 2, p. 283 - 287
  • 21
  • [ 65873-72-5 ]
  • [ 58584-63-7 ]
YieldReaction ConditionsOperation in experiment
90%
Stage #1: With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;
Stage #2: With water; ethyl acetate In toluene
EXAMPLE 25 : 1-(3,4-Difluorobenzyl)-5-(phenoxymethyl)pyridin-2(1H)-one (Final Compound 16-03) ;Step 1 : (6-Methoxypyridin-3-yl)methanol According to Scheme 16 Method A: A solution of 6-methoxynicotinaldehyde (leq, 2.19mmol, 0.30g) and LiAlH4 (0.5eq, 1.05mmol, 0.04g) in THF (10mL) was stirred for 30 min. at 0°C and overnight at room temperature. After the addition of AcOEt, the reaction mixture was diluted with water. The organic layer was washed with saturated NH4Cl solution, dried over Na2SO4, filtered and evaporated. The resulting crude residue was purified by silica gel chromatography (AIT Flashsmart prepacked column 25g SiO2) using CH2Cl2/AcOEt 80/20 to afford (6-methoxypyridin-3-yl)methanol (1.80mmol, 0.26g, 90percent) as a pale oil. LC (XTerra RP18, 3.5μm, 3.0x50mm Column): RT = 1.86min; MS m/z (CI) [MH]+= 140.
Reference: [1] Patent: WO2006/30032, 2006, A1, . Location in patent: Page/Page column 104-105
[2] Patent: US4990622, 1991, A,
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4721 - 4734
  • 22
  • [ 65873-72-5 ]
  • [ 74-88-4 ]
  • [ 123506-66-1 ]
  • [ 123506-67-2 ]
Reference: [1] Journal of Organic Chemistry, 1990, vol. 55, # 1, p. 69 - 73
  • 23
  • [ 65873-72-5 ]
  • [ 101990-70-9 ]
YieldReaction ConditionsOperation in experiment
74%
Stage #1: With sodium tetrahydroborate In methanol at 0℃; for 1 h;
Stage #2: With ammonium chloride In methanol; water
Reference Example 28Step 15-chloromethyl-2-methoxypyridine (Compound A80)2-methoxy-5-pyridinecarbaldehyde (137 mg, 0.999 mmol) was dissolved in methanol (5.0mL). To this, sodium borohydride (37.8 mg, 0.999 mmol) was added at 0°C, and the mixture was stirred for 1 hour. To the reaction mixture, a saturated ammonium chloride aqueous solution was added, and extraction with ethyl acetate was performed twice. The organic layer was washed with a saturated sodium chloride aqueous solution and dried over anhydrous magnesium sulfate. After filtration and concentration under reduced pressure, the residue was dissolved in dichloromethane (5.0 mL). To this, triethylamine (278 μL, 2.00 mmol) and methanesulfonyl chloride (116 μL, 1.50 mmol) were added, and the mixture was stirred overnight. After a saturated aqueous solution of sodium hydrogen carbonate was added to the reaction mixture, extraction with chloroform was performed twice. The organic layer was dried over anhydrous magnesium sulfate. After filtration and concentration under reduced pressure, the residue was purified by silica gel column chromatography to give Compound A80 (116 mg, yield: 74percent). ESI-MS: m/z 158 [M + H]+; 1H NMR (CDCl3)δ(ppm): 3.94 (s, 3H), 4.55 (s, 2H), 6.76 (d, J = 8.4 Hz, 1H), 7.62 (dd, J = 2.4, 8.4 Hz, 1H), 8.15 (d, J = 2.4 Hz, 1H).
Reference: [1] Patent: EP2308880, 2011, A1, . Location in patent: Page/Page column 56
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4721 - 4734
  • 24
  • [ 65873-72-5 ]
  • [ 106984-91-2 ]
YieldReaction ConditionsOperation in experiment
37% at 100℃; for 12 h; Intermediate 150: 6-Hydroxypyridine-3-carbaldehydeTo A 100 mL RB was charged with 6-methoxypyridine-3-carbaldehyde (1 g, 7 mmol) was added 3N HCI (20 mL) and then refluxed it at 100 °C for 12h. RM was cooled slowly to RT. Solid was obtained up on cooling. It was filtered off on Buchner flask and dried under line vacuum to obtain the title compound as white crystals (0.3g, Yield: 37percent)
Reference: [1] Patent: WO2012/11125, 2012, A1, . Location in patent: Page/Page column 184-185
[2] Patent: WO2006/135627, 2006, A2, . Location in patent: Page/Page column 133
  • 25
  • [ 65873-72-5 ]
  • [ 132865-44-2 ]
Reference: [1] Patent: US5051513, 1991, A,
Recommend Products
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 65873-72-5 ]

Aldehydes

Chemical Structure| 97455-61-3

[ 97455-61-3 ]

6-Ethoxynicotinaldehyde

Similarity: 0.98

Chemical Structure| 884495-35-6

[ 884495-35-6 ]

6-Isopropoxynicotinaldehyde

Similarity: 0.94

Chemical Structure| 123506-66-1

[ 123506-66-1 ]

6-Methoxy-4-methylnicotinaldehyde

Similarity: 0.94

Chemical Structure| 635712-99-1

[ 635712-99-1 ]

6-(Benzyloxy)nicotinaldehyde

Similarity: 0.91

Chemical Structure| 1211577-99-9

[ 1211577-99-9 ]

6-(Difluoromethoxy)nicotinaldehyde

Similarity: 0.86

Ethers

Chemical Structure| 97455-61-3

[ 97455-61-3 ]

6-Ethoxynicotinaldehyde

Similarity: 0.98

Chemical Structure| 884495-35-6

[ 884495-35-6 ]

6-Isopropoxynicotinaldehyde

Similarity: 0.94

Chemical Structure| 123506-66-1

[ 123506-66-1 ]

6-Methoxy-4-methylnicotinaldehyde

Similarity: 0.94

Chemical Structure| 635712-99-1

[ 635712-99-1 ]

6-(Benzyloxy)nicotinaldehyde

Similarity: 0.91

Chemical Structure| 13472-56-5

[ 13472-56-5 ]

2-Methoxy-5-methylpyridine

Similarity: 0.90

Related Parent Nucleus of
[ 65873-72-5 ]

Pyridines

Chemical Structure| 97455-61-3

[ 97455-61-3 ]

6-Ethoxynicotinaldehyde

Similarity: 0.98

Chemical Structure| 884495-35-6

[ 884495-35-6 ]

6-Isopropoxynicotinaldehyde

Similarity: 0.94

Chemical Structure| 123506-66-1

[ 123506-66-1 ]

6-Methoxy-4-methylnicotinaldehyde

Similarity: 0.94

Chemical Structure| 635712-99-1

[ 635712-99-1 ]

6-(Benzyloxy)nicotinaldehyde

Similarity: 0.91

Chemical Structure| 13472-56-5

[ 13472-56-5 ]

2-Methoxy-5-methylpyridine

Similarity: 0.90