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[ CAS No. 66003-78-9 ] {[proInfo.proName]}

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Chemical Structure| 66003-78-9
Chemical Structure| 66003-78-9
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Product Details of [ 66003-78-9 ]

CAS No. :66003-78-9 MDL No. :MFCD01940916
Formula : C19H15F3O3S2 Boiling Point : -
Linear Structure Formula :- InChI Key :FAYMLNNRGCYLSR-UHFFFAOYSA-M
M.W : 412.45 Pubchem ID :11729320
Synonyms :

Safety of [ 66003-78-9 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P403+P233-P405-P501 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 66003-78-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 66003-78-9 ]

[ 66003-78-9 ] Synthesis Path-Downstream   1~85

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YieldReaction ConditionsOperation in experiment
52% With hydrogen bromide; In n-heptane; dichloromethane; benzene; After the removal of ether, a mixture of 50 mL benzene and 100 mL heptane was added to a reactor and then, the reaction temperature was increased up to 80 C. 12.1 g of diphenyl sulfoxide was dissolved in 75 mL benzene and then, this solution was slowly added to a solution containing phenyl magnesium bromide. Hence, the temperature of reacting solution was kept at 8 C. and after the addition was completed, the reacting mixture was stirred at the same temperature for 3 hours and cooled to room temperature. With a slow addition of 200 mL of 25% HBr aqueous solution, the aqueous solution layer was separated, while an organic layer was extracted two times using 30 mL of 5% HBr aqueous solution. After the collection of the aqueous solution, so extracted, the solution was further extracted with 250 mL dichloromethane. The dichloromethane layer, so extracted, was dried over anhydrous magnesium sulfate and then, the solvent was evaporated under vacuum drying. The remaining compound in oil phase was recrystallized using dichloromethane and ether, and dried to obtain 10.8 g of triphenyl sulfonium triflate (yield: 52%).
52% With hydrogen bromide; In n-heptane; dichloromethane; benzene; After the removal of ether, a mixture of 50mL benzene and 100mL heptane was added to a reactor and then, the reaction temperature was increased up to 80C. 12.1 g of diphenyl sulfoxide was dissolved in 75mL benzene and then, this solution was slowly added to a solution containing phenyl magnesium bromide. Hence, the temperature of reacting solution was kept at 8C and after the addition was completed, the reacting mixture was stirred at the same temperature for 3 hours and cooled to room temperature. With a slow addition of 200mL of 25% HBr aqueous solution, the aqueous solution layer was separated, while an organic layer was extracted two times using 30mL of 5% HBr aqueous solution. After the collection of the aqueous solution, so extracted, the solution was further extracted with 250mL dichloromethane. The dichloromethane layer, so extracted, was dried over anhydrous magnesium sulfate and then, the solvent was evaporated under vacuum drying. The remaining compound in oil phase was recrystallized using dichloromethane and ether, and dried to obtain 10.8g of triphenyl sulfonium triflate (yield: 52%).
  • 4
  • (H<SUB>2</SUB>IMes)(Cl)<SUB>2</SUB>(PCy<SUB>3</SUB>)RuC [ No CAS ]
  • [ 67191-35-9 ]
  • [ 66003-78-9 ]
  • [ 301224-40-8 ]
  • C20H36P(1+)*CF3O3S(1-) [ No CAS ]
  • 5
  • C20H14F2O5S2*CF3O3S(1-)*Na(1+) [ No CAS ]
  • [ 66003-78-9 ]
  • [ 1421591-16-3 ]
YieldReaction ConditionsOperation in experiment
90% In dichloromethane; water; at 25℃; for 5h; A mixed solution prepared by dissolving 50 g of the compound represented by [A] in the following reaction scheme (1-5) and 27 g of <strong>[66003-78-9]triphenylsulfonium trifluoromethanesulfonate</strong> represented by [B] in the following formula (1-5) in 200 ml of dichloromethane (MC) and 200 ml of distilled water was vigorously stirred for 5 hours at room temperature (about 25 C.), and thus a reaction solution was prepared. The completion point of the reaction of the reaction solution was confirmed by 19F-NMR, and after completion of the reaction, the reaction solution was washed with an aqueous solution of K2CO3 and distilled water. The organic layer was concentrated, and thus a reaction liquid was prepared. The crude reaction liquid was purified using dichloromethane and hexane, and thus 50.2 g (yield 90%) of a compound represented by [C] in the following reaction scheme (1-5) was obtained.
  • 6
  • diphenyl(trifluoromethanesulfonato)-λ3-iodane [ No CAS ]
  • [ 139-66-2 ]
  • [ 66003-78-9 ]
  • 7
  • C12H17F2O7S2(1-)*Na(1+) [ No CAS ]
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  • C12H17F2O7S2(1-)*C18H15S(1+) [ No CAS ]
YieldReaction ConditionsOperation in experiment
In dichloromethane; water; at 20℃; for 1h; The reaction solution in the step 1 as the final result obtained, add the 10g of <strong>[66003-78-9]triphenylsulfonium triflate</strong> (iv) was dissolved in 100ml dichloromethane (DICHLOROMETHANE) was added, also adds to the amount of the methylene chloride similar amount of distilled water, stirred vigorously for 1 hour. By 19F NMR to confirm whether the reaction is carried out, removing the separated aqueous layer was substituted with the end, after the organic layer was collected and the solvent was distilled off under reduced pressure, washed with hexane several times, to give the title compound (v).
  • 8
  • Na(1+)*C4H7F2O5S(1-) [ No CAS ]
  • [ 66003-78-9 ]
  • C4H7F2O5S(1-)*C18H15S(1+) [ No CAS ]
YieldReaction ConditionsOperation in experiment
In dichloromethane; water; at 20℃; for 1h; The reaction solution in the step 1 as the final result obtained, add the 10g of <strong>[66003-78-9]triphenylsulfonium triflate</strong> (triphenyl sulfonium triflate) (iv) was dissolved in 100ml dichloromethane (DICHLOROMETHANE) was added, also adds to the amount of the methylene chloride similar amount of distilled water, stirred vigorously for 1 hour. By 19F NMR to confirm whether the reaction is carried out, removing the separated aqueous layer was substituted with the end, after the organic layer was collected and the solvent was distilled off under reduced pressure, washed with hexane several times, to give the title compound (v).
  • 9
  • C7H11F2O6S(1-)*Na(1+) [ No CAS ]
  • [ 66003-78-9 ]
  • C7H11F2O6S(1-)*C18H15S(1+) [ No CAS ]
YieldReaction ConditionsOperation in experiment
In dichloromethane; water; at 20℃; for 1h; The reaction solution in the step 1 as the final result obtained, add the 10g of <strong>[66003-78-9]triphenylsulfonium triflate</strong> (triphenyl sulfonium triflate) (iv) was dissolved in 100ml of methylene chloride (dichloromethane) was added, also adds to the amount of the methylene chloride similar amount of distilled water, stirred vigorously for 1 hour. By 19F NMR to confirm whether the reaction is carried out, removing the separated aqueous layer was substituted with the end, after the organic layer was collected and the solvent was distilled off under reduced pressure, washed with hexane several times, to give the title compound (viii).
  • 10
  • [ 5122-94-1 ]
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YieldReaction ConditionsOperation in experiment
92%Chromat. With bis(tri-t-butylphosphine)palladium(0); sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 60℃; for 6h;Inert atmosphere; General procedure: General procedure: a mixture of 1a (0.4 mmol), 2 (0.6 mmol), Pd[P(t-Bu)3]2 (0.02 mmol), NaHCO3 (0.8mmol), and DMF (10 mL) was reacted at 60 oC under an inert atmosphere in a Schlenk flask. A small aliquot (100 μL) from the reaction mixture was quenched and diluted with methanol (to 5.0 mL) and measured by HPLC at 0, 20, 40, 60, 80, 100, 120, 150, 180, and 360 min for each sulfonium salt. Yields of 3a were determined by HLPC using 1,1':4',1''-terphenyl as the external standard (tR = 6.145min, λmax = 278.3 nm, water /methanol = 10 : 90 (v / v)).
  • 11
  • [ 139-66-2 ]
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YieldReaction ConditionsOperation in experiment
90% With cesium fluoride; In acetonitrile; at 25℃;Inert atmosphere; At room temperature, evacuate in a 25 mL reaction tube and change nitrogen three times.136.7 mg (0.9 mmol) of cesium fluoride was added under nitrogen protection.(CsF is weighed in a glove box and added to the reaction system three times)Acetonitrile (3 mL) followed by 55.9 mg (0.3 mmol) of diphenyl sulfide.Finally, 2-(trimethylsilyl)phenyltrifluoromethanesulfonate (268.5 mg, 0.9 mmol) was added.The reaction was carried out at 25 C. Track the progress of the reaction by thin layer chromatography.The developing solvent was dichloromethane/methanol in a volume ratio of 15:1, and the reaction time was 36 h.After the reaction is completed, the reaction material is filtered through a short column of column chromatography to remove cesium fluoride.The organic layer was concentrated under reduced pressure and purified by column chromatography to give the desired product. yield is 90%.
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  • C4H5F2O6S(1-)*K(1+) [ No CAS ]
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YieldReaction ConditionsOperation in experiment
In chloroform; at 23℃; for 36.5h; 10.00 parts of a salt represented by the formula (I-10-1) and 30 parts of chloroform were added and stirred at 23 C. for 30 minutes, 3.12 parts of a salt represented by the formula (I-10-2) was added, and the mixture was stirred at 23 C. for 36 hours. The resulting reaction mass was filtered to obtain 1.71 parts of a salt represented by the formula (I-10-3).
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  • N-cyclopentyl-N,N-diphenylamine [ No CAS ]
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  • [ 5397-31-9 ]
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  • N-(3-((2-ethylhexyl)oxy)propyl)-N-phenylaniline [ No CAS ]
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  • N-(3-((2-ethylhexyl)oxy)propyl)aniline [ No CAS ]
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  • [ 768-94-5 ]
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  • (3s,5s,7s)-N,N-diphenyladamantan-1-amine [ No CAS ]
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  • N-(1,3-benzodioxol-5-yl)-N-phenylamine [ No CAS ]
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  • N-phenyl-2-allylaniline [ No CAS ]
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  • tert-butyl phenyl-L-prolinate [ No CAS ]
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  • ammonium tetrathiomonomolybdate [ No CAS ]
  • cobalt(II) chloride hexahydrate [ No CAS ]
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  • triphenylsulfonium cobalt thiomolybdate [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% In water; acetonitrile; A precursor sulfonium thiosalt was triphenylsulfoniumcobalt thiomolybdate [(Ph)3S]2Co(MoS4)2. Thesynthesis techniques [25, 26] were modified as follows:the solution of 0.12 g of Cl2 · 6H2O in 7 mL ofH2O-CH3CN mixture (volume ratio H2O : CH3CN =1 : 2.5) was added to the solution of 0.26 g of(NH4)2MoS4 (99.9%) in 13 mL of H2O-CH3CN mixture(volume ratio H2O : CH3CN = 1 : 1.4). To theresulting mixture, a solution containing 2.0 g of[(Ph)3S]CF3SO3 (98%) and 7.5 mL of CH3CN wasadded. The resulting black precipitate was filtered off,washed with water, isopropanol, and diethyl ether, anddried in air. The yield of the product was 90%.
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  • N-4-(phenoxymethyl)phenylacetamide [ No CAS ]
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  • [ 495-76-1 ]
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  • 5-(phenoxymethyl)benzo[d][1,3]dioxole [ No CAS ]
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  • N-(4-(4-fluorophenyl)-6-isopropyl-5-(phenoxymethyl)pyrimidin-2-yl)-N-methylmethanesulfonamide [ No CAS ]
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  • (3αS,5αR,8αR,8βS)-2,2,7,7-tetramethyl-3α-(phenoxymethyl)tetrahydro-5H-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran [ No CAS ]
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  • 1-methyl-3-phenylpropyl phenyl ether [ No CAS ]
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  • [ 66003-78-9 ]
  • 1,2:5,6-di-O-isopropylidene-α-L-glucofuranose [ No CAS ]
  • (3αS,5S,6R,6αS)-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-6-phenoxytetrahydrofuro[2,3-d][1,3]dioxole [ No CAS ]
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  • N-(2-phenoxyethyl)-N-phenylaniline [ No CAS ]
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  • 5-methoxybenzoxazole [ No CAS ]
  • [ 66003-78-9 ]
  • 5‐methoxy‐2‐phenylbenzo[d]oxazole [ No CAS ]
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  • [ 66003-78-9 ]
  • 6-fluorobenzo[d]oxazole [ No CAS ]
  • 6-fluoro-2-phenyl-1,3-benzoxazole [ No CAS ]
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