Alternatived Products of [ 66067-43-4 ]
Product Details of [ 66067-43-4 ]
| CAS No. : | 66067-43-4 |
MDL No. : | MFCD01662328 |
| Formula : |
C15H14O
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | FVSYHKJWZIKKDM-UHFFFAOYSA-N |
| M.W : |
210.27
|
Pubchem ID : | 583730 |
| Synonyms : |
|
Application In Synthesis of [ 66067-43-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 66067-43-4 ]
- Downstream synthetic route of [ 66067-43-4 ]
- 1
-
[ 17988-51-1 ]
-
[ 98-88-4 ]
-
[ 18220-90-1 ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 60%
2: 5% |
With chlorure d'aluminium In dichloromethane for 48h; Heating; |
|
- 2
-
[ 22071-15-4 ]
-
[ 66067-43-4 ]
-
[ 108125-13-9 ]
-
[ 67173-18-6 ]
-
2,2′-((1,2-dihydroxy-1,2-diphenylethane-1,2-diyl)bis(3,1-phenylene))dipropanoic acid
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 6.1%
2: 7.6%
3: 46%
4: 1% |
With phosphate-buffered saline for 1h; Irradiation; sunlight; Further byproducts given; |
|
- 3
-
[ 22071-15-4 ]
-
[ 66067-43-4 ]
-
[ 66067-44-5 ]
-
[ 67173-18-6 ]
-
2,3-bis-(3-benzoylphenyl)butane
[ No CAS ]
-
2-(3-benzoylphenyl)-1-(3-ethylphenyl)-1-phenylpropan-1-ol
[ No CAS ]
-
2,2′-((1,2-dihydroxy-1,2-diphenylethane-1,2-diyl)bis(3,1-phenylene))dipropanoic acid
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 46%
2: 6.1%
3: 3.5%
4: 2.8%
5: 5.6%
6: 7.6% |
With phosphate-buffered saline; deuterated methanol In water Irradiation; natural sunlight or pyrex-filtered light of a medium-pressure mercury lamp in oxygen or argon atmosphere at different concentrations; |
|
- 4
-
[ 22071-15-4 ]
-
[ 66067-43-4 ]
-
[ 66067-44-5 ]
-
[ 67173-18-6 ]
-
2,2′-((1,2-dihydroxy-1,2-diphenylethane-1,2-diyl)bis(3,1-phenylene))dipropanoic acid
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 6.1%
2: 7.6%
3: 46%
4: 3.5% |
With phosphate-buffered saline for 1h; Irradiation; sunlight; Further byproducts given; |
|
- 5
-
[ 22071-15-4 ]
-
[ 66067-43-4 ]
-
[ 67173-18-6 ]
-
3-(1-hydroperoxyethyl)benzophenone
[ No CAS ]
-
2,2′-((1,2-dihydroxy-1,2-diphenylethane-1,2-diyl)bis(3,1-phenylene))dipropanoic acid
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 6.1%
2: 7.6%
3: 46%
4: 1.2% |
With phosphate-buffered saline for 1h; Irradiation; sunlight; Further byproducts given; |
|
- 6
-
[ 22071-15-4 ]
-
[ 66067-43-4 ]
-
[ 67173-18-6 ]
-
2,3-bis-(3-benzoylphenyl)butane
[ No CAS ]
-
2,2′-((1,2-dihydroxy-1,2-diphenylethane-1,2-diyl)bis(3,1-phenylene))dipropanoic acid
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 3.1%
2: 8.3%
3: 29%
4: 3.2% |
With phosphate-buffered saline for 1h; Irradiation; Further byproducts given; |
|
- 7
-
[ 22071-15-4 ]
-
[ 66067-43-4 ]
-
[ 67173-18-6 ]
-
2-(3-benzoylphenyl)-1-(3-ethylphenyl)-1-phenylpropan-1-ol
[ No CAS ]
-
2,2′-((1,2-dihydroxy-1,2-diphenylethane-1,2-diyl)bis(3,1-phenylene))dipropanoic acid
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 6.1%
2: 7.6%
3: 5.6%
4: 46% |
With phosphate-buffered saline for 1h; Irradiation; sunlight; Further byproducts given; |
|
| 1: 46%
2: 7.6%
3: 5.6%
4: 6.1% |
With phosphste-buffered saline for 1h; Irradiation; sunlight; Further byproducts given; |
|
| 1: 3.1%
2: 8.3%
3: 29%
4: 6.3% |
With phosphate-buffered saline for 1h; Irradiation; Further byproducts given; |
|
Reference：
[1]Bosca; Miranda; Carganico; Mauleon
[Photochemistry and photobiology, 1994, vol. 60, # 2, p. 96 - 101]
[2]Bosca; Miranda; Carganico; Mauleon
[Photochemistry and photobiology, 1994, vol. 60, # 2, p. 96 - 101]
[3]Bosca; Miranda; Carganico; Mauleon
[Photochemistry and photobiology, 1994, vol. 60, # 2, p. 96 - 101]
- 8
-
[ 22071-15-4 ]
-
[ 66067-43-4 ]
-
1,2-bis-(3-ethylphenyl)-1,2-diphenyl-1,2-ethanediol
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 4%
2: 83% |
With sodium hydroxide In methanol for 1h; Irradiation; |
|
- 9
-
[ 22071-15-4 ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
at 22℃; laser flash photolysis; |
|
|
In acetonitrile Irradiation; other solvents methanol, cyclohexane; |
|
|
With phosphate buffer; sodium chloride Irradiation; |
|
|
With sodium hydroxide In methanol UV-irradiation; |
|
|
With sodium hydroxide at 9.5 - 29℃; Irradiation; |
|
|
With sodium hydride In tetrahydrofuran Flash photolysis; |
|
|
In water; acetonitrile Photolysis; |
|
|
With sulfuric acid In water; acetonitrile UV-irradiation; |
|
|
With L-histidine In aq. phosphate buffer UV-irradiation; |
|
|
Multi-step reaction with 2 steps
1: 20 °C
2: methanol / UV-irradiation |
|
|
Multi-step reaction with 2 steps
1: 20 °C
2: methanol / UV-irradiation |
|
|
Multi-step reaction with 2 steps
1: 20 °C
2: methanol / UV-irradiation |
|
|
Multi-step reaction with 2 steps
1: 20 °C
2: methanol / UV-irradiation |
|
|
Multi-step reaction with 2 steps
1: 20 °C
2: methanol / UV-irradiation |
|
|
With sodium hydroxide In water; acetonitrile for 0.0833333h; Photolysis; |
|
Reference：
[1]Monti, Sandra; Sortino, Salvatore; De Guidi, Guido; Marconi, Giancarlo
[Journal of the Chemical Society - Faraday Transactions, 1997, vol. 93, # 13, p. 2269 - 2275]
[2]Martínez; Scaiano
[Journal of the American Chemical Society, 1997, vol. 119, # 45, p. 11066 - 11070]
[3]Encinas, Susana; Miranda, Miguel A.; Marconi, Giancarlo; Monti, Sandra
[Photochemistry and Photobiology, 1998, vol. 67, # 4, p. 420 - 425]
[4]Cosa, Gonzalo; Martinez, Lydia J.; Scaiano
[Physical Chemistry Chemical Physics, 1999, vol. 1, # 15, p. 3533 - 3537]
[5]Borsarelli, Claudio D.; Braslavsky, Silvia E.; Sortino, Salvatore; Marconi, Giancarlo; Monti, Sandra
[Photochemistry and Photobiology, 2000, vol. 72, # 2, p. 163 - 171]
[6]Laferriere, Marie; Sanrame, Carlos N.; Scaiano
[Organic Letters, 2004, vol. 6, # 6, p. 873 - 875]
[7]Mitchell, Devin; Lukeman, Matthew; Lehnherr, Dan; Wan, Peter
[Organic Letters, 2005, vol. 7, # 15, p. 3387 - 3389]
[8]Location in patent: experimental part
Li, Ming-De; Yeung, Chi Shun; Guan, Xiangguo; Ma, Jiani; Li, Wen; Ma, Chensheng; Phillips, David Lee
[Chemistry - A European Journal, 2011, vol. 17, # 39, p. 10935 - 10950]
[9]Suzuki, Tadashi; Shinoda, Mio; Osanai, Yohei; Isozaki, Tasuku
[Journal of Physical Chemistry B, 2013, vol. 117, # 33, p. 9662 - 9668]
[10]Arimitsu, Koji; Endo, Ryosuke
[Chemistry of Materials, 2013, vol. 25, # 22, p. 4461 - 4463]
[11]Arimitsu, Koji; Endo, Ryosuke
[Chemistry of Materials, 2013, vol. 25, # 22, p. 4461 - 4463]
[12]Arimitsu, Koji; Endo, Ryosuke
[Chemistry of Materials, 2013, vol. 25, # 22, p. 4461 - 4463]
[13]Arimitsu, Koji; Endo, Ryosuke
[Chemistry of Materials, 2013, vol. 25, # 22, p. 4461 - 4463]
[14]Arimitsu, Koji; Endo, Ryosuke
[Chemistry of Materials, 2013, vol. 25, # 22, p. 4461 - 4463]
[15]Wang, Yu-Hsuan; Wan, Peter
[Photochemical and Photobiological Sciences, 2015, vol. 14, # 6, p. 1120 - 1126]
- 10
-
[ 119-61-9 ]
-
[ 64-17-5 ]
-
[ 18220-90-1 ]
-
[ 22679-42-1 ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With sulfuric acid for 24h; other benzenes with meta-directing groups, other alcohols; |
|
- 11
-
[ 100-41-4 ]
-
[ 98-88-4 ]
-
[ 18220-90-1 ]
-
[ 22679-42-1 ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With perfluorobutanesulfonic acid at 136℃; for 15h; Title compound not separated from byproducts; |
|
|
With bismuth(lll) trifluoromethanesulfonate; 1-(n-butyl)-3-methylimidazolium triflate at 140℃; for 0.5h; Microwave irradiation; Green chemistry; Overall yield = 84 %; |
Typical procedure for the benzoylation reaction in ionic liquids:
General procedure: a glass tube was filled with Bi(OTf)3 (0.0328 g, 0.05 mmol), [BMIM]OTf (0.1 g), anisole (0.108 g, 1 mmol), and benzoyl chloride (0.281 g, 2 mmol) and reacted at 120 °C for 30 min under microwave activation. After cooling, the mixture was extracted with Et2O (3 × 20 mL). The organic layer was decanted, washed with water (10 mL), aqueous NaHCO3 (2 × 20mL), brine (10 mL), and dried over MgSO4. The solvent was removed using a rotary evaporator. Conversion was determined by GC analysis using n-hexadecane as the internal standard. The isolated yield was determined after purification by flash chromatography (n-hexane, then 10 % EtOAc in n-hexane) to give 4-methoxybenzophenone (0.1993 g, 94 % yield). The purity and authenticity of the product were confirmed by GC-MS and 1H NMR spectroscopy. The same procedure was carried out under conventional heating method. |
|
With bismuth(lll) trifluoromethanesulfonate In neat (no solvent) at 140℃; for 0.666667h; Sealed tube; Microwave irradiation; Overall yield = 92 %; |
EXPERIMENTAL
General procedure: A 10-mL pressurized glass tube with Teflon-coated septum equipped with amagnetic stirrer was charged with substrate (1 mmol), benzoyl chloride (1 mmol),and metal triflate (0.1 equiv). The tube was sealed and placed into a CEM microwaveat the temperature for the appropriate time. The reaction mixture was allowed tocool to the room temperature in the MW oven. After cooling, water (15 mL) wasadded to the mixture and the product was extracted by ethyl acetate or dichloromethane,which gave similar results (315mL). The organic layer was decanted;washed with water, aqueous NaHCO3, and brine; and dried with MgSO4. Thesolvent was then removed on a rotary evaporator and subjected to flash chromatographyon silica gel (mixture of hexane and ethyl acetate solvent to elute theproduct). The fractions containing product were concentrated and dried undervacuum to yield pure product. All products are known compounds; the purity and identityof all products were confirmed by GC-MS and 1H and 13C NMR spectroscopy. |
Reference：
[1]Effenberger; Buckel; Maier; Schmider
[Synthesis, 2000, # 10, p. 1427 - 1430]
[2]Hoangtran, Phuong; Bichle Do, Ngoc; Ngocle, Thach
[Tetrahedron Letters, 2014, vol. 55, # 1, p. 205 - 208]
[3]Tran, Phuong Hoang; Hansen, Poul Erik; Pham, Thuy Thanh; Huynh, Vy Thanh; Huynh, Vy Hieu; Thi Tran, Thao Du; Huynh, Thanh Van; Le, Thach Ngoc
[Synthetic Communications, 2014, vol. 44, # 20, p. 2921 - 2929]
- 12
-
[ 57495-14-4 ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With zeolite NaY In various solvent(s) UV-irradiation; |
|
- 13
-
[ 66067-43-4 ]
-
[ 60695-82-1 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane |
|
|
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane |
1.1 (1)
(1) Synthesis of 3-(1-bromoethyl)benzophenone Into a 200 ml reactor equipped with a reflux condenser and a stirrer, 60 ml of carbon tetrachloride and 10 g of the above mentioned fraction containing 3-ethylbenzophenone were introduced. While stirring the resultant mixture at room temperature, 8.6 g of N-bromosuccinimide and 0.14 g of benzoyl peroxide were added thereto, and reflux was perfomed for 8 hours while stirring the reaction solution. After the reaction solution had been cooled to room temperature, the succinimide was filtered out, and carbon tetrachloride was distilled off from a filtrate under a reduced pressure. The spectrum data of the obtained product were in accord with those of 3-(1-bromoethyl)benzophenone. |
|
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane |
4 (4)
(4) Synthesis of 3-(1-bromoethyl)benzophenone (III) Into a 200 ml reactor equipped with a reflux condenser and a stirrer, 60 ml of carbon tetrachloride and 10 g of 3-ethylbenzophenone were introduced. While stirring the resultant mixture at room temperature, 8.6 g of N-bromosuccinimide and 0.14 g of benzoyl peroxide were added thereto, and reflux was performed for 8 hours while stirring the reaction solution. After the reaction solution had been cooled to room temperature, the succinimide was filtered out, and carbon tetrachloride was distilled off from a filtrate under a reduced pressure. The spectrum data of the obtained product were in accord with those of 3-(1-bromoethylbenzophenone. |
Reference：
[1]Mitchell, Devin; Lukeman, Matthew; Lehnherr, Dan; Wan, Peter
[Organic Letters, 2005, vol. 7, # 15, p. 3387 - 3389]
[2]Current Patent Assignee: ENEOS (in: ENEOS Holdings); ENEOS HOLDINGS INC - US4734528, 1988, A
[3]Current Patent Assignee: ENEOS (in: ENEOS Holdings); ENEOS HOLDINGS INC - US4761508, 1988, A
- 14
-
[ 22161-81-5 ]
-
[ 66067-43-4 ]
- 15
-
[ 56105-81-8 ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
In phosphate buffer at 25℃; Photolysis; |
|
Reference：
[1]Monti, Sandra; Manet, Ilse; Manoli, Francesco; Morrone, Raffaele; Nicolosi, Giovanni; Sortino, Salvatore
[Photochemistry and Photobiology, 2006, vol. 82, # 1, p. 13 - 19]
- 16
-
[ 66067-43-4 ]
-
[ 67173-18-6 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: NBS; benzoyl peroxide / CCl4
2: CaCO3 / H2O; dioxane / Heating |
|
- 17
-
[ 66067-43-4 ]
-
4-acetylbenzhydrol
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: NBS; benzoyl peroxide / CCl4
2: CaCO3 / H2O; dioxane / Heating
3: H2SO4 / acetonitrile; H2O / 0.08 h / pH 2 / Photolysis |
|
- 18
-
[ 128254-32-0 ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 100 percent / acide trifluoroacetique / CCl4 / 15 h / Heating
2: 60 percent / chlorure d'aluminium / CH2Cl2 / 48 h / Heating |
|
| Yield | Reaction Conditions | Operation in experiment |
| 97% |
|
2 (2)
With stirring the suspension, 2 liter of an 1.6% aqueous solution of potassium permanganate was dropped. After the dropping, the stirring was continued for about 10 hours at room temperature. After this mixture was acidified with concentrated sulfuric acid, sodium hydrogensulfite powder was added until the reaction mixture became transparent from brown and it was extracted with benzene. After drying the benzene layer with anhydrous magnesium sulfate, 3-ethylbenzophenone was obtained in a yield of 97% by reduced pressure distillation. |
|
|
3 (3)
(3) Synthesis of 3-ethylbenzophenone (II) In a 50 ml reactor equipped with a stirrer, 20 g of 1,1-(3-ethylphenyl)phenylethylene and 40 mg of cobalt naphthenate were put, and pure oxygen was blown thereinto at a reaction temperature of 110° C. at 50 ml/min for 10 hours. According to the results of gas chromatography and MASS analysis, the conversion of 1,1-(3-ethylphenyl)phenylethylene and the selectivity of 3-ethylbenzophenone were 98.1% and 89%, respectively. |
|
|
3 (2)
3) Friedel-Crafts alkylation is carried out with benzophenone and diethyl sulfate in the presence of aluminum chloride to form 3-ethylbenzophenone. |
- 20
-
[ 22161-81-5 ]
-
(2S)-2-[3-(hydroxy(4-hydroxycyclohexa-2,5-dienylidene)methyl)phenyl]propanoic acid
[ No CAS ]
-
[ 66067-43-4 ]
- 21
-
[ 24589-78-4 ]
-
[ 66067-43-4 ]
-
C12H16O3Si
[ No CAS ]
-
C17H20O2Si
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Stage #1: 3-ethylbenzophenone With water UV-irradiation;
Stage #2: N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide In ethyl acetate at 60℃; for 1h; |
|
- 22
-
[ 22071-15-4 ]
-
3-(1,2-dihydroxyethyl)benzophenone
[ No CAS ]
-
[ 66067-43-4 ]
-
[ 28286-79-5 ]
-
[ 66067-44-5 ]
-
[ 67173-18-6 ]
-
4-acetylbenzhydrol
[ No CAS ]
- 23
-
[ 66067-43-4 ]
-
[ 56338-25-1 ]
-
[ 137474-24-9 ]
-
3-(1,2-dihydroxyethyl)benzophenone
[ No CAS ]
-
[ 586-42-5 ]
-
[ 579-18-0 ]
-
[ 28286-79-5 ]
-
[ 67173-18-6 ]
- 24
-
[ 66067-43-4 ]
-
[ 67173-18-6 ]
-
[ 319482-67-2 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With dihydrogen peroxide In water UV-irradiation; |
|
- 25
-
[ 66067-43-4 ]
-
[ 77377-52-7 ]
-
C14H22O3Si
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Stage #1: 3-ethylbenzophenone With water UV-irradiation;
Stage #2: N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide In ethyl acetate at 60℃; for 1h; |
|
- 26
-
[ 1198425-21-6 ]
-
[ 66067-43-4 ]
-
[ 6674-22-2 ]
| Yield | Reaction Conditions | Operation in experiment |
|
In methanol UV-irradiation; |
|
|
In chloroform-d1 for 0.166667h; Irradiation; |
|
Reference：
[1]Arimitsu, Koji; Endo, Ryosuke
[Chemistry of Materials, 2013, vol. 25, # 22, p. 4461 - 4463]
[2]Khan, Anzar; Yeo, Hyunki
[Journal of the American Chemical Society, 2020, vol. 142, # 7, p. 3479 - 3488]
- 27
-
[ 1284221-92-6 ]
-
[ 66067-43-4 ]
-
[ 3001-72-7 ]
| Yield | Reaction Conditions | Operation in experiment |
|
In methanol UV-irradiation; |
|
- 28
-
[ 1333123-47-9 ]
-
[ 66067-43-4 ]
-
[ 5807-14-7 ]
| Yield | Reaction Conditions | Operation in experiment |
|
In methanol UV-irradiation; |
|
- 29
-
C6H19N4P*C16H14O3
[ No CAS ]
-
[ 49778-01-0 ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
In methanol UV-irradiation; |
|
- 30
-
[ 81928-83-8 ]
-
[ 66067-43-4 ]
-
[ 108-91-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|
In methanol UV-irradiation; |
|
- 31
-
[ 100-41-4 ]
-
[ 65-85-0 ]
-
[ 18220-90-1 ]
-
[ 22679-42-1 ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With erbium(III) triflate In neat (no solvent) at 180℃; for 0.333333h; Microwave irradiation; Overall yield = 78 %; |
General procedure
General procedure: mixture of Er(OTf)3 (0.0614 g, 0.1 mmol), anisole(0.5407 g, 5 mmol) and benzoic acid (0.1221 g, 1 mmol) was heated undermicrowave irradiation at 220 C for 30 min in a CEM Discover apparatus. Afterbeing cooled, the mixture was extracted with CH2Cl2 (3 15 mL). The organiclayer was decanted, washed with H2O (10 mL), aqueous NaHCO3 (2 20 mL),and brine (10 mL), and dried over MgSO4. The solvent was removed on a rotaryevaporator. The crude product was purified by flash chromatography (nhexane,then 10% EtOAc in n-hexane) to give 4-methoxybenzophenone(0.153 g, 72% yield). The purity and identity of the product were confirmedby GC-FID, and from GC-MS spectra which were compared with the spectra inthe NIST library, and by 1H and 13C NMR spectroscopy. |
- 32
-
[ 22071-15-4 ]
-
[ 87-41-2 ]
-
[ 85-44-9 ]
-
[ 119-61-9 ]
-
[ 13020-57-0 ]
-
[ 63444-57-5 ]
-
[ 643-65-2 ]
-
[ 57872-48-7 ]
-
[ 66067-43-4 ]
-
[ 32388-73-1 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With dihydrogen peroxide; iron(II); In water; at 20℃;pH 2.0; |
General procedure: For the Fenton degradation experiment, 10 mL of a Milli Q water sample acidified at pH 2 with 100 muL H2SO4 0.5 mol/L containing 200 ng of each studied anti-inflammatory drug (diclofenac sodium, ibuprofen and ketoprofen) was placed into a 50 mL brown glass bottle. Immediately, 500 muL of Fe2+solution (1 mg/mL Fe2+) and 200 muL of H2O2 (30%) were added into the brown bottle which was kept under magnetic stirring and room temperature for different time intervals in order to perform the degradation process. Because the catalyst (Fe2+) and the oxidant (H2O2) are consumed very fast, these were refreshed at each 30 minutes in the same amounts as it was described previously. To study the Fenton oxidative process efficiency over the selected drugs, different experiments at 30, 60 and 120 minutes were performed. After each Fenton oxidative experiment, the degradation by-products of NAIDs were extracted with organic solvent and analyzed by GC×GC-qMS. |
- 33
-
[ 22071-15-4 ]
-
[ 292638-85-8 ]
-
[ 66067-43-4 ]
-
methyl 4-(3-benzoylphenyl)pentanoate
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 83 %Spectr.
2: 11 %Spectr. |
With sodium hydroxide In water; acetonitrile |
|
- 34
-
2-(3-benzoylphenyl)-propanol
[ No CAS ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With perchloric acid In water; acetonitrile Irradiation; |
|
- 35
-
C16H13O3(1-)*K(1+)
[ No CAS ]
-
[ 66067-43-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
In ethanol; water at 25℃; for 1h; UV-irradiation; |
|
Reference：
[1]Menichetti, Arianna; Mavridi-Printezi, Alexandra; Falini, Giuseppe; Besirske, Patricia; García-Ruiz, Juan Manuel; Cölfen, Helmut; Montalti, Marco
[Chemistry - A European Journal, 2021, vol. 27, # 49, p. 12521 - 12525]
- 36
-
[ 66067-43-4 ]
-
[ 66067-44-5 ]
| Yield | Reaction Conditions | Operation in experiment |
| 61% |
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; oxygen; tetra-n-butylammonium azide In acetonitrile at 25℃; for 36h; Irradiation; |
|
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