[ CAS No. 6628-28-0 ] {[proInfo.proName]}

Name: 6628-28-0|2-Methyl-6-ethoxyquinoline|97%
Brand: Ambeed
SKU: A787200
Price: 12.0 USD
Availability: InStock
Rating: 98 (35 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 6628-28-0

Structure of 6628-28-0 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

For Research Only 120K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 6628-28-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 6628-28-0 ]

SDS Specification

Alternatived Products of [ 6628-28-0 ]

Product Details of [ 6628-28-0 ]

CAS No. :	6628-28-0	MDL No. :	MFCD00023987
Formula :	C₁₂H₁₃NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	VTGXHCUQALWXCR-UHFFFAOYSA-N
M.W :	187.24	Pubchem ID :	81118
Synonyms :

Calculated chemistry of [ 6628-28-0 ] Expand+

Physicochemical Properties

Num. heavy atoms :	14
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.25
Num. rotatable bonds :	2
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	58.01
TPSA :	22.12 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.36 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.62
Log Po/w (XLOGP3) :	2.93
Log Po/w (WLOGP) :	2.94
Log Po/w (MLOGP) :	2.06
Log Po/w (SILICOS-IT) :	3.25
Consensus Log Po/w :	2.76

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.24
Solubility :	0.107 mg/ml ; 0.000571 mol/l
Class :	Soluble
Log S (Ali) :	-3.06
Solubility :	0.165 mg/ml ; 0.000879 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.62
Solubility :	0.00448 mg/ml ; 0.0000239 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.35

Safety of [ 6628-28-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 6628-28-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 6628-28-0 ]

[ 6628-28-0 ] Synthesis Path-Downstream 1~50

1
[ 6628-28-0 ]
[ 120-57-0 ]
[ 109647-41-8 ]

Yield	Reaction Conditions	Operation in experiment
	With acetic anhydride

Reference： [1]Horwitz [Journal of the American Chemical Society, 1955, vol. 77, p. 1687,1690]

2
[ 6628-28-0 ]
[ 99-61-6 ]
6-ethoxy-2-(3-nitro-trans-styryl)-quinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With acetic anhydride

Reference： [1]Horwitz [Journal of the American Chemical Society, 1955, vol. 77, p. 1687,1690]

3
[ 6628-28-0 ]
[ 555-16-8 ]
6-ethoxy-2-(4-nitro-trans-styryl)-quinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With acetic anhydride

Reference： [1]Horwitz [Journal of the American Chemical Society, 1955, vol. 77, p. 1687,1690]

4
[ 6628-28-0 ]
[ 591-51-5 ]
2-(6-ethoxy-[2]quinolyl)-1-(4-dimethylamino-phenyl)-ethanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With diethyl ether Erwaermen des Reaktionsgemisches mit 4-Dimethylamino-benzaldehyd;

Reference： [1]Bergstrom; Furst [Journal of the American Chemical Society, 1953, vol. 75, p. 5415]

5
[ 6628-28-0 ]
[ 105-07-7 ]
4-[trans-2-(6-ethoxy-[2]quinolyl)-vinyl]-benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With zinc(II) chloride

Reference： [1]Fields [Journal of the American Chemical Society, 1949, vol. 71, p. 1495]

6
[ 6628-28-0 ]
[ 77-78-1 ]
[ 68516-69-8 ]

Yield	Reaction Conditions	Operation in experiment
	With acetone

Reference： [1]Sawicki et al. [Analytica Chimica Acta, 1959, vol. 21, p. 392,393]

7
[ 156-43-4 ]
[ 123-63-7 ]
[ 6628-28-0 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; water
	With hydrogenchloride; aluminium trichloride

Reference： [1]Bergstrom; Furst [Journal of the American Chemical Society, 1953, vol. 75, p. 5415]
[2]Current Patent Assignee: Chem. Fabr. Schering - DE24317, 1800, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 188][Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 188]

8
[ 110-86-1 ]
[ 6628-28-0 ]
[ 117622-58-9 ]

Yield	Reaction Conditions	Operation in experiment
40%	With iodine

Reference： [1]Kuehmstedt, H.; Heinisch, L.; Wunderlich, Ines; Hagen, Angela [Pharmazie, 1987, vol. 42, # 12, p. 816 - 820]

9
[ 6628-28-0 ]
[ 74-88-4 ]
[ 63151-41-7 ]

Yield	Reaction Conditions	Operation in experiment
	at 100 - 105℃; for 12h;

Reference： [1]Jyothish, Kuthanapillil; Arun, Kalliat T.; Ramaiah, Danaboyina [Organic Letters, 2004, vol. 6, # 22, p. 3965 - 3968]

10
[ 156-43-4 ]
[ 123-73-9 ]
[ 6628-28-0 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride for 6h; Heating;

Reference： [1]Jyothish, Kuthanapillil; Arun, Kalliat T.; Ramaiah, Danaboyina [Organic Letters, 2004, vol. 6, # 22, p. 3965 - 3968]

11
[ 6628-28-0 ]
3-butoxy-4-(6-ethoxy-1-methyl-1H-quinolin-2-ylidenemethyl)-cyclobut-3-ene-1,2-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 12 h / 100 - 105 °C 2: 90 percent / quinoline / benzene / 24 h / 100 - 105 °C

Reference： [1]Jyothish, Kuthanapillil; Arun, Kalliat T.; Ramaiah, Danaboyina [Organic Letters, 2004, vol. 6, # 22, p. 3965 - 3968]

12
2-(4-ethoxyphenylazo)-5-methyl-1-vinylpyrrole [ No CAS ]
[ 6628-28-0 ]

Yield	Reaction Conditions	Operation in experiment
26%	With trifluoroacetic acid In isopropyl alcohol for 6h; Heating;

Reference： [1]Shmidt; Senotrusova; Ushakov; Protsuk; Mikhaleva; Trofimov [Russian Journal of Organic Chemistry, 2007, vol. 43, # 10, p. 1495 - 1501]

13
[ 64-17-5 ]
[ 156-43-4 ]
[ 6628-28-0 ]

Yield	Reaction Conditions	Operation in experiment
91%	With platinum-loaded TiO₂ nanoparticles at 30℃; for 4h; Irradiation; Inert atmosphere;
88%	With gold on titanium oxide at 30℃; for 4h; UV-irradiation; Inert atmosphere;
	at 30℃; for 4h; UV-irradiation; Inert atmosphere;

Reference： [1]Location in patent: experimental part Selvam, Kaliyamoorthy; Sreedhar, Bojja; Swaminathan, Meenakshisundaram [Research on Chemical Intermediates, 2012, vol. 38, # 3-5, p. 761 - 773]
[2]Location in patent: scheme or table Selvam; Swaminathan [Tetrahedron Letters, 2010, vol. 51, # 37, p. 4911 - 4914]
[3]Selvam; Swaminathan [Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 2013, vol. 43, # 4, p. 500 - 508]

14
[ 6628-28-0 ]
[ 193140-69-1 ]
ethyl-2-amino-3,3,3-trifluoro-2-(5-ethoxyquinolin-2-ylmethyl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With trifluorormethanesulfonic acid In 1,4-dioxane at 20 - 100℃; for 12h; Inert atmosphere;	General procedure triflic acid-catalyzed the Csp3-H functionalization of 2-methylazaarenes with a-trifluoromethyl imino este General procedure: Ethyl trifluoro imino ester 2(50 mg, 0.18 mmol) and 2-methyl quinoline 1a (49 lL, 0.36 mol) were placedin a screw-cap pressure tube along with 2 mL 1,4-dioxane. The mixture wasflushed with argon and stirred for 2 min at room temperature. Triflic acid (4 lL,20 mol %) was added with constant stirring. The closed tube was stirred at100 C for 12 h. After the reaction was completed, as indicated by TLC and 19FNMR, the resulting reaction mixture was directly subjected to columnchromatography (hexane/ethyl acetate 90:10 to 50:50) to obtain a whitesolid in 81% isolated yield.

Reference： [1]Blocker, Mark; Immaneni, Supriya; Shaikh, Abid [Tetrahedron Letters, 2014, vol. 55, # 40, p. 5572 - 5575]

15
[ 6628-28-0 ]
[ 100-46-9 ]
7-ethoxy-1-phenylimidazo[1,5-a]quinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
52%	With ammonium iodide In N,N-dimethyl-formamide at 100℃; for 24h; Electrochemical reaction;
42%	With copper(l) iodide; di-tert-butyl peroxide; copper(II) acetate monohydrate In dimethyl sulfoxide at 110℃; for 24h;

Reference： [1]Qian, Peng; Yan, Zicong; Zhou, Zhenghong; Hu, Kangfei; Wang, Jiawei; Li, Zhibin; Zha, Zhenggen; Wang, Zhiyong [Organic Letters, 2018, vol. 20, # 20, p. 6359 - 6363]
[2]Li, Zhong; Wu, Song-Song; Luo, Zai-Gang; Liu, Wei-Kang; Feng, Cheng-Tao; Ma, Shi-Tang [Journal of Organic Chemistry, 2016, vol. 81, # 10, p. 4386 - 4392]

16
[ 6628-28-0 ]
[ 100063-12-5 ]

Yield	Reaction Conditions	Operation in experiment
93%	With [bis(acetoxy)iodo]benzene In dimethyl sulfoxide at 120℃; for 0.5h; Microwave irradiation; Sealed tube; Green chemistry; regioselective reaction;	Experimental Procedures Typical experimental procedure for oxidation of 2-methylquinolines General procedure: Unless otherwise noted, reactions were carried out as following: 2-methylquinolines 1 (2 mmol), PIDA (4 mmol), DMSO(10 mL) were mixed in a sealed microwave tube. The reaction mixture was stirred at 120 °C for 30 min under microwave irradiation using a CEM Discover microwave reactor (the highest power: 85 W; run time: 10 min; hold time: 30 min; temperature: 120 °C). The resulting reaction mixture was neutralized with saturated aqueous NaHCO3 solution and extracted with Et2O. The combined organic layers were washed with H2O and dried over Na2SO4, then concentrated under reduced pressure. The crude residue was purified by flash chromatographyon silica gel using hexane/EtOAc as eluent.
	With iodine; dimethyl sulfoxide at 110℃; Sealed tube;
	With iodine; dimethyl sulfoxide; trifluoroacetic acid at 130℃; for 3h; Sealed tube;

Reference： [1]Jiang, Long; Huang, Yingyi; Yan, Yiyan; Xie, Yuanyuan [Tetrahedron Letters, 2016, vol. 57, # 37, p. 4149 - 4151]
[2]Hu, Qi-Qi; Gao, Yan-Ting; Sun, Jia-Chen; Gao, Jing-Jing; Mu, Hong-Xiao; Li, Yi-Ming; Zheng, Ya-Nan; Yang, Kai-Rui; Zhu, Yan-Ping [Organic Letters, 2021, vol. 23, # 22, p. 9000 - 9005]
[3]Zhang, Xin-Ke; Miao, Xiao-Yu; Zhou, Yu; Wang, Yu-Mei; Song, Ying-Chun; Liu, Hang; Xiong, Yi-Lu; Li, Ling-Yu; Wu, An-Xin; Zhu, Yan-Ping [Organic and Biomolecular Chemistry, 2022, vol. 20, # 6, p. 1236 - 1242]

17
[ 6628-28-0 ]
[ 24964-64-5 ]
[ 762-21-0 ]
diethyl 3-(3-cyanobenzyl)-7-ethoxypyrrolo[1,2-a]quinoline-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	Stage #1: 6-ethoxy-2-methyl-quinoline; 3-Cyanobenzaldehyde In chlorobenzene at 140℃; Sealed tube; Green chemistry; Stage #2: acetylenedicarboxylic acid diethyl ester In chlorobenzene at 120℃; for 8h; Sealed tube; Green chemistry;

Reference： [1]Wu, Fu-Song; Zhao, Hai-Yuan; Xu, Yan-Li; Hu, Kun; Pan, Ying-Ming; Ma, Xian-Li [Journal of Organic Chemistry, 2017, vol. 82, # 8, p. 4289 - 4296]

18
[ 6628-28-0 ]
[ 387-45-1 ]
[ 762-21-0 ]
diethyl 3-(2-chloro-6-fluorobenzyl)-7-ethoxypyrrolo[1,2-a]-quinoline-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	Stage #1: 6-ethoxy-2-methyl-quinoline; 2-chloro-6-fluorobenzaldehyde In chlorobenzene at 140℃; Sealed tube; Green chemistry; Stage #2: acetylenedicarboxylic acid diethyl ester In chlorobenzene at 120℃; for 8h; Sealed tube; Green chemistry;

Reference： [1]Wu, Fu-Song; Zhao, Hai-Yuan; Xu, Yan-Li; Hu, Kun; Pan, Ying-Ming; Ma, Xian-Li [Journal of Organic Chemistry, 2017, vol. 82, # 8, p. 4289 - 4296]

19
[ 6628-28-0 ]
[ 769-92-6 ]
6-(tert-butyl)-2-(6-ethoxyquinolin-2-yl)benzo[d]thiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87%	With ammonium iodide; sulfur In 1-methyl-pyrrolidin-2-one at 160℃; Sealed tube;

Reference： [1]Li, Guozheng; Xie, Hao; Chen, Jinjin; Guo, Yanjun; Deng, Guo-Jun [Green Chemistry, 2017, vol. 19, # 17, p. 4043 - 4047]

20
[ 6628-28-0 ]
[ 15814-30-9 ]
C₂₉H₂₃NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	In N,N-dimethyl-formamide at 100℃; for 10h; Sealed tube;	2 Example 2 2-(4'-hydroxy-2',6'-diphenyl)phenyl-6-ethoxyquinoline According to the general formula, 6-ethoxy-2-methylquinoline was added successively to 25 mL of the sealed tube(1b, 0.6 mmol), diacetylene (2b, 0.5 mmol), DMF (1 mL) and 100 oC for 10 h. The reaction was quenched with TLC. After completion of the reaction, the mixture was cooled to room temperature and the solvent was distilled off under reduced pressure And purified by flash silica gel column chromatography (eluent: petroleum ether: ethyl acetate = 10: 1) to give pale yellow solid 163 mg in 78% yield. The structural formula was:
58%	In neat (no solvent) at 100℃; for 6h; Sealed tube;

Reference： [1]Current Patent Assignee: GUANGXI NORMAL UNIVERSITY - CN107033073, 2017, A Location in patent: Paragraph 0010
[2]Zhao, Hai-Yuan; Wu, Fu-Song; Yang, Li; Liang, Ying; Cao, Xiao-Lin; Wang, Heng-Shan; Pan, Ying-Ming [RSC Advances, 2018, vol. 8, # 9, p. 4584 - 4587]

21
[ 6628-28-0 ]
C₂₁H₁₂O [ No CAS ]
C₃₃H₂₅NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%	In neat (no solvent) at 100℃; for 8h; Sealed tube;

Reference： [1]Zhao, Hai-Yuan; Wu, Fu-Song; Yang, Li; Liang, Ying; Cao, Xiao-Lin; Wang, Heng-Shan; Pan, Ying-Ming [RSC Advances, 2018, vol. 8, # 9, p. 4584 - 4587]

22
[ 4930-98-7 ]
[ 6628-28-0 ]
2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-ethoxyquinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	Stage #1: 6-ethoxy-2-methyl-quinoline With iodine; dimethyl sulfoxide at 110℃; Sealed tube; Stage #2: pyrid-2-ylhydrazine at 110℃; Sealed tube;

Reference： [1]Weng, Wei-Zhao; Gao, Yin-He; Zhang, Xue; Liu, Yan-Hua; Shen, Ying-Jie; Zhu, Yan-Ping; Sun, Yuan-Yuan; Meng, Qing-Guo; Wu, An-Xin [Organic and Biomolecular Chemistry, 2019, vol. 17, # 8, p. 2087 - 2091]

23
[ 109-99-9 ]
[ 6628-28-0 ]
C₁₆H₂₁NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; lithium bromide In water; chlorobenzene for 60h; Irradiation; Inert atmosphere;	35 The method for synthesizing polysubstituted quinolines and derivatives includes the following steps: General procedure: Step 1: Put quinoline compounds (see Table 1 for specific substances), lithium bromide, water, acid (see Table 1 for specific substances) and add to the reaction vessel. The catalysts (see Table 1 for specific substances) and organic solvents (specific materials) See Table 1) Add to the reaction vessel and mix well;Step 2: The reaction vessel is subjected to inert gas extraction three times, an ether compound is added, and the reactor is uniformly irradiated with blue light (such as a blue LED lamp), and the quinoline compound and the ether compound are reacted in a solvent, and the reaction is continued. The time stated in 1;Step 3: Purification is carried out after completion of the reaction.

Reference： [1]Current Patent Assignee: XIANGTAN UNIVERSITY - CN109776406, 2019, A Location in patent: Paragraph 0056-0062; 0064; 0166

24
[ 6628-28-0 ]
[ 7677-24-9 ]
[ 100-46-9 ]
7-ethoxy-1-phenylimidazo[1,5-a]quinoline-3-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With ammonium iodide; ammonium tetrafluoroborate; diphenyl-phosphinic acid In N,N-dimethyl acetamide at 90℃; for 24h; Electrolysis; Green chemistry;

Reference： [1]Qian, Peng; Zhou, Zhenghong; Hu, Kangfei; Wang, Jiawei; Li, Zhibin; Zha, Zhenggen; Wang, Zhiyong [Organic Letters, 2019, vol. 21, # 16, p. 6403 - 6407]

25
[ 6628-28-0 ]
7-ethoxy-[1,2,3]triazolo[1,5-a]quinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%	Stage #1: 6-ethoxy-2-methyl-quinoline With iodine In dimethyl sulfoxide at 110℃; for 4h; Stage #2: With potassium phosphate tribasic trihydrate; toluene-4-sulfonic acid hydrazide In dimethyl sulfoxide at 110℃; for 6h;	10 Example 10: Preparation adding 0.3 mmol of 6-ethoxy-2-methylquinoline, 0.75 mmol of elemental iodine, and 2 mL of dimethyl sulfoxide to a 15 mL pressure-resistant tube, and magnetically stirring the reaction at 110 ° C for 4 hours. After cooling, 0.36 mmol of p-toluenesulfonylhydrazide and 0.9 mmol of potassium phosphate trihydrate were added, and magnetic stirring was carried out at 110 ° C for 6 hours. After the reaction was completed, the reaction solution was extracted, and the organic layer was washed, dried, and evaporated under reduced pressure. The solvent is the crude product, and the crude product is purified by column with petroleum ether/ethyl acetate=1.5:12:1 (V/V) as the eluent to obtain the desired product. The product is yellow solid, the yield is 74%
64%	Stage #1: 6-ethoxy-2-methyl-quinoline With iodine In dimethyl sulfoxide at 110℃; Sealed tube; Stage #2: With potassium phosphate tribasic trihydrate; toluene-4-sulfonic acid hydrazide In dimethyl sulfoxide at 110℃; for 5h; Sealed tube;

Reference： [1]Current Patent Assignee: YANTAI UNIVERSITY - CN110105355, 2019, A Location in patent: Paragraph 0085-0089
[2]Shang, Zhi-Hao; Zhang, Zhen-Xiao; Weng, Wei-Zhao; Wang, Yu-Fei; Cheng, Tian-Wei; Zhang, Qiu-Yi; Song, Li-Qun; Shao, Tian-Qi; Liu, Kai-Xuan; Zhu, Yan-Ping [Advanced Synthesis and Catalysis, 2021, vol. 363, # 2, p. 490 - 496]

26
[ 6628-28-0 ]
[ 536-74-3 ]
3-(6-ethoxyquinolin-2-yl)-5-phenylisoxazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	With ammonium iodide; tert.-butylnitrite; 2,4-dinitrobenzoic acid In N,N-dimethyl acetamide at 110℃; for 1.5h;

Reference： [1]Wang, Dahan; Zhang, Feng; Xiao, Fuhong; Deng, Guo-Jun [Organic and Biomolecular Chemistry, 2019, vol. 17, # 41, p. 9163 - 9168]

27
[ 6628-28-0 ]
[ 19434-34-5 ]
2-(6-ethoxyquinolin-2-yl)-1-(2-phenoxyphenyl)ethan-1-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
47%	With acetic acid In water at 100℃; for 24h;

Reference： [1]Wu, Yinrong; Lu, Xianchen; Wang, Hang; Liang, En; Yuan, Yingying; Zhao, Qiaorun; Zhu, Zhongzhi; Huang, Jiaping; Tang, Xiaodong [European Journal of Organic Chemistry, 2019, vol. 2019, # 45, p. 7452 - 7462]

28
[ 6628-28-0 ]
8-bromo-6-ethoxy-2-methylquinoline N-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C / Schlenk technique; Sealed tube 2: N-Bromosuccinimide; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; sodium acetate / 2,2,2-trifluoroethanol / 12 h / 50 °C / Sealed tube

Reference： [1]Dhiman, Ankit Kumar; Gupta, Shiv Shankar; Sharma, Ritika; Kumar, Rakesh; Sharma, Upendra [Journal of Organic Chemistry, 2019, vol. 84, # 20, p. 12871 - 12880]

29
[ 6628-28-0 ]
6-ethoxy-2-methylquinoline N-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54%	With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 14h; Schlenk technique; Sealed tube;
	With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 12h; Schlenk technique;

Reference： [1]Dhiman, Ankit Kumar; Gupta, Shiv Shankar; Sharma, Ritika; Kumar, Rakesh; Sharma, Upendra [Journal of Organic Chemistry, 2019, vol. 84, # 20, p. 12871 - 12880]
[2]Dhiman, Ankit Kumar; Thakur, Ankita; Kumar, Inder; Kumar, Rakesh; Sharma, Upendra [Journal of Organic Chemistry, 2020, vol. 85, # 14, p. 9244 - 9254]

30
[ 6628-28-0 ]
[ 6642-31-5 ]
5-(6-ethoxyquinolin-2-yl)-1,3,7,9-tetramethylpyrido[2,3-d:6,5-d']dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetraone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With iodine In dimethyl sulfoxide at 110℃; for 10h;	8 To a 15 mL pressure-resistant tube, 0.3 mmol of 6-ethoxy-2-methylquinoline, 0.66 mmol of 6-amino-1,3-dimethylpyrimidine-2,4 (1H, 3H) -dione, 0.45 mmol I2, 2mL DMSO, the reaction mixture was stirred at 110 ° C for 10 hours under air environment, and then the reaction solution was extracted with ethyl acetate. The organic layer was washed with 10% sodium thiosulfate solution (w / w), and dried over anhydrous sodium sulfate. Then, the crude product was concentrated under reduced pressure and dried under vacuum to obtain a crude product. The crude product was purified by column separation using ethyl acetate / petroleum ether = 2: 1 (V / V) as the eluent to obtain the desired product. The product was a white solid. The yield was 76%.
76%	With iodine In dimethyl sulfoxide at 120℃; for 6h; Sealed tube;

Reference： [1]Current Patent Assignee: YANTAI UNIVERSITY - CN110790763, 2020, A Location in patent: Paragraph 0097; 0098; 0099; 0100; 0101; 0102
[2]Zhang, Xin-Ke; Miao, Xiao-Yu; Jiang, Hui-Ru; Ge, Fei; Sun, Jia-Chen; Zhang, Rui-Ying; Ouyang, Qin; Fan, Wei-Yu; Zhu, Yan-Ping; Sun, Yuan-Yuan [Advanced Synthesis and Catalysis, 2021, vol. 363, # 19, p. 4632 - 4638]

31
[ 6628-28-0 ]
[ 765-87-7 ]
2-ethoxy-6-methyl-5,6,8,9,10,11-hexahydro-4H-pyrido[3,2,1-jk]carbazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	With formic acid; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; trifluoroacetic acid In para-xylene at 120℃; for 16h; Inert atmosphere; Schlenk technique;

Reference： [1]Jiang, Huanfeng; Lu, Guangpeng; Xie, Feng; Xie, Rong; Zhang, Min [Organic Letters, 2020, vol. 22, # 6, p. 2308 - 2312]

32
[ 6628-28-0 ]
[ 89-25-8 ]
C₃₂H₂₅N₅O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59%	With iodine; trifluoroacetic acid In dimethyl sulfoxide at 130℃; for 6h;	10 Add 6-ethoxy-2-methylquinoline to 25mL pressure tube,0.6mmol 3-methyl-1-phenyl-2-pyrazoline-5-one, 0.03mmol I2, 2mL DMSO, the reaction mixture was stirred at 130°C for 6 hours in an air environment,The reaction solution was extracted with ethyl acetate, the organic layer was washed with 10% sodium thiosulfate solution (w/w), dried over anhydrous sodium sulfate, concentrated under reduced pressure and dried under vacuum to obtain a crude product.The crude product uses ethyl acetate/petroleum ether=1:8 (V/V) as the eluent for column separation and purification to obtain the desired product.The product was a white solid with a yield of 59%.

Reference： [1]Current Patent Assignee: YANTAI UNIVERSITY - CN111440181, 2020, A Location in patent: Paragraph 0091-0096

33
[ 6628-28-0 ]
8-benzamido-6-ethoxy-2-methylquinoline N-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C / Schlenk technique 2: acetic acid; Cp*Co(CO)I₂; silver hexafluoroantimonate / 12 h / 50 °C

Reference： [1]Dhiman, Ankit Kumar; Thakur, Ankita; Kumar, Inder; Kumar, Rakesh; Sharma, Upendra [Journal of Organic Chemistry, 2020, vol. 85, # 14, p. 9244 - 9254]

34
[ 6628-28-0 ]
[ 66-83-1 ]
C₂₃H₁₉N₃O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With iodine In dimethyl sulfoxide at 130℃; Sealed tube; Green chemistry;	12 Example 12: This example is used to illustrate the preparation of the compound of the structure represented by formula L.The reaction formula is:Add 0.3mmol 2-methyl-6-ethoxyquinoline, 0.36mmol 5-methoxytryptamine hydrochloride, 0.45mmol I2and 2mL dimethyl sulfoxide into a 15mL pressure tube, and then The pressure-resistant tube was sealed and placed in an oil bath at 130°C and stirred for 6-10 hours. After the reaction, it was extracted with dichloromethane and water. During the extraction, sodium thiosulfate and sodium hydroxide were added to treat the reaction solution. The layer was washed with saturated brine, dried over anhydrous sodium sulfate, and evaporated to remove the solvent under reduced pressure to obtain the crude product. The crude product was separated by column with ethyl acetate/petroleum ether=1:5 (V/V) as the eluent The desired product is obtained after purification, and the product is a white solid with a yield of 75%.

Reference： [1]Current Patent Assignee: YANTAI UNIVERSITY - CN110776510, 2020, A Location in patent: Paragraph 0121-0127; 0163

35
[ 6628-28-0 ]
[ 119-53-9 ]
2-(6-ethoxyquinolin-2-yl)-4,5-diphenyloxazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	Stage #1: 6-ethoxy-2-methyl-quinoline With iodine; dimethyl sulfoxide at 120℃; Sealed tube; Stage #2: 2-hydroxy-2-phenylacetophenone With ammonium acetate at 120℃; Molecular sieve; Sealed tube;

Reference： [1]Kong, Hong-Mei; Liang, Fei-Fei; Liu, Kai-Xuan; Shang, Zhi-Hao; Sun, Yuan-Yuan; Yao, Jian-Wen; Yin, Ya-Qing; Zhao, Cong; Zhu, Yan-Ping [European Journal of Organic Chemistry, 2021, vol. 2021, # 6, p. 998 - 1002]

36
[ 613-21-8 ]
[ 75-03-6 ]
[ 6628-28-0 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Cooling with ice;

Reference： [1]Hong, Xin; Shi, Shi-Liang; Wang, Zi-Chao; Xie, Pei-Pei; Xu, Youjun [Angewandte Chemie - International Edition, 2021, vol. 60, # 29, p. 16077 - 16084][Angew. Chem., 2021, vol. 133, # 29, p. 16213 - 16220]

37
[ 6628-28-0 ]
C₁₂H₁₇NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium tetrahydroborate; nickel dichloride In methanol at 20℃; Inert atmosphere;

38
[ 6628-28-0 ]
(S)-6-ethoxy-2-methyl-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinoline [ No CAS ]
C₁₂H₁₇NO [ No CAS ]
C₁₂H₁₇NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: nickel dichloride; sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere 2: bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium <i>tert</i>-butylate; lithium tert-butoxide; 7,9-bis(4-methyl-2,6-bis((R)-1-phenylethyl)phenyl)-7H-acenaphtho[1,2-d]imidazol-9-ium chloride / Cyclopentane / 24 h / 0 °C / Inert atmosphere

39
[ 6628-28-0 ]
C₁₂H₁₇NO [ No CAS ]
C₁₉H₂₀N₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: nickel dichloride; sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere 2: bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium <i>tert</i>-butylate; lithium tert-butoxide; 7,9-bis(4-methyl-2,6-bis((R)-1-phenylethyl)phenyl)-7H-acenaphtho[1,2-d]imidazol-9-ium chloride / Cyclopentane / 36 h / -30 °C / Inert atmosphere

40
[ 6628-28-0 ]
[ 6630-33-7 ]
2-(6-ethoxyquinolin-2-yl)benzo[b]thiophen-3-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With sulfur; potassium carbonate In dimethyl sulfoxide at 130℃; for 24h;

Reference： [1]Wang, Dahan; Xiao, Fuhong; Zhang, Feng; Deng, Guo-Jun [Chinese Journal of Chemistry, 2021, vol. 39, # 9, p. 2483 - 2488]

41
[ 6628-28-0 ]
[ 90221-55-9 ]
2-(6-ethoxyquinolin-2-yl)-5-methylbenzo[b]thiophen-3-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With sulfur; potassium carbonate In dimethyl sulfoxide at 130℃; for 24h;

Reference： [1]Wang, Dahan; Xiao, Fuhong; Zhang, Feng; Deng, Guo-Jun [Chinese Journal of Chemistry, 2021, vol. 39, # 9, p. 2483 - 2488]

42
[ 6628-28-0 ]
[ 1192-21-8 ]
(5-amino-1-methyl-1H-pyrazol-4-yl)(6-ethoxyquinolin-2-yl)methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71%	With iodine In dimethyl sulfoxide at 130℃; for 6h; Sealed tube;

Reference： [1]Zhang, Xin-Ke; Miao, Xiao-Yu; Jiang, Hui-Ru; Ge, Fei; Sun, Jia-Chen; Zhang, Rui-Ying; Ouyang, Qin; Fan, Wei-Yu; Zhu, Yan-Ping; Sun, Yuan-Yuan [Advanced Synthesis and Catalysis, 2021, vol. 363, # 19, p. 4632 - 4638]

43
[ 3524-32-1 ]
[ 6628-28-0 ]
(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(6-ethoxyquinolin-2-yl)methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58%	With iodine In dimethyl sulfoxide at 120℃; for 6h; Sealed tube;

44
[ 3524-32-1 ]
[ 6628-28-0 ]
4-(6-ethoxyquinolin-2-yl)-1,3,5,7-tetramethyl-1,7-dihydrodipyrazolo[3,4-b:4',3'-e]pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
24%	With iodine In dimethyl sulfoxide at 120℃; for 6h; Sealed tube;

45
[ 6628-28-0 ]
[ 1131-18-6 ]
4-(6-ethoxyquinolin-2-yl)-3,5-dimethyl-1,7-diphenyl-1,7-dihydrodipyrazolo[3,4-b:4',3'-e]pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
55%	With iodine In dimethyl sulfoxide at 120℃; for 6h; Sealed tube;

46
[ 6628-28-0 ]
4-(6-ethoxyquinolin-2-yl)-5-methyl-2,7-diphenyl-2,9-dihydrooxepino[2,3-c:6,5-c']dipyrazol-3(7H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: trifluoroacetic acid; iodine; dimethyl sulfoxide / 3 h / 130 °C / Sealed tube 2.1: trifluoroacetic acid; iodine; dimethyl sulfoxide / 3 h / 130 °C / Inert atmosphere 2.2: Inert atmosphere

Reference： [1]Zhang, Xin-Ke; Miao, Xiao-Yu; Zhou, Yu; Wang, Yu-Mei; Song, Ying-Chun; Liu, Hang; Xiong, Yi-Lu; Li, Ling-Yu; Wu, An-Xin; Zhu, Yan-Ping [Organic and Biomolecular Chemistry, 2022, vol. 20, # 6, p. 1236 - 1242]

47
[ 6628-28-0 ]
4-(6-ethoxyquinolin-2-yl)-5-methyl-2,7-di-p-tolyl-2,9-dihydrooxepino[2,3-c:6,5-c']dipyrazol-3(7H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: trifluoroacetic acid; iodine; dimethyl sulfoxide / 3 h / 130 °C / Sealed tube 2.1: trifluoroacetic acid; iodine; dimethyl sulfoxide / 3 h / 130 °C / Inert atmosphere 2.2: Inert atmosphere

48
[ 6628-28-0 ]
[ 28144-70-9 ]
2-(6-ethoxyquinolin-2-yl)quinazolin-4(3H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With oxalic acid; tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 100℃; Electrolysis;

Reference： [1]Hu, Kangfei; Li, Zhibin; Wang, Zhiyong; Zha, Zhenggen; Zhang, Yan; Zhou, Zhenghong [Chemical Communications, 2022, vol. 58, # 3, p. 411 - 414]

49
[ 6628-28-0 ]
[ 611-73-4 ]
(6-ethoxy-2-methylquinolin-4-yl)(phenyl)methanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With trifluorormethanesulfonic acid; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; water monomer; Zinc di(trifluoromethanesulphonate) In methanol at 50℃; for 48h; Inert atmosphere; Irradiation;

Reference： [1]Ji, Xiaochen; Yang, Zhonglin; Wu, Xinzhuang; Deng, Guo-Jun; Huang, Huawen [Journal of Organic Chemistry, 2022, vol. 87, # 6, p. 4168 - 4182]

50
[ 6628-28-0 ]
[ 29681-57-0 ]
4-(tert-butyldimethylsilyl)-6-ethoxy-2-methylquinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
52%	With 2-(benzyloxy)-7-(10H-phenothiazin-10-yl)-3a,3a1,7,8-tetrahydro-1H-benzo[de]isoquinoline-1,3(2H)-dione; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate); trifluoroacetic acid In propan-2-one; acetonitrile at 20℃; for 24h; Inert atmosphere; Irradiation; Schlenk technique;

Reference： [1]Zhang, Wenjuan; Lu, Qi; Wang, Mengshi; Zhang, Yongjin; Xia, Xiao-Feng; Wang, Dawei [Organic Letters, 2022, vol. 24, # 21, p. 3797 - 3801]

Recommend Products

Same Skeleton Products

Related Products

Isomers

Technical Information

• Acetal Formation • Esters Are Reduced by LiAlH4 to Give Alcohols • Esters Hydrolyze to Carboxylic Acids and Alcohols • Ether Synthesis by Oxymercuration-Demercuration • Ethers Synthesis from Alcohols with Strong Acids • Grignard Reagents Transform Esters into Alcohols • Nomenclature of Ethers • Preparation of Ethers • Primary Ether Cleavage with Strong Nucleophilic Acids • Reactions of Ethers • Ring Opening of Oxacyclopropane • Synthesis of Alcohols from Tertiary Ethers • The Nucleophilic Opening of Oxacyclopropanes

Historical Records

Related Functional Groups of
[ 6628-28-0 ]

Ethers

[ 1078-28-0 ]

6-Methoxy-2-methylquinoline

Similarity: 0.93

[ 19490-87-0 ]

7-Methoxy-2-methylquinoline

Similarity: 0.91

[ 1134334-84-1 ]

5-Isopropoxy-2-methyl-1H-indole

Similarity: 0.89

[ 79205-04-2 ]

5-Methoxy-2-methylquinoline

Similarity: 0.89

[ 1076-74-0 ]

5-Methoxy-2-methyl-1H-indole

Similarity: 0.89

Related Parent Nucleus of
[ 6628-28-0 ]

Quinolines

[ 1078-28-0 ]

6-Methoxy-2-methylquinoline

Similarity: 0.93

[ 19490-87-0 ]

7-Methoxy-2-methylquinoline

Similarity: 0.91

[ 79205-04-2 ]

5-Methoxy-2-methylquinoline

Similarity: 0.89

[ 100063-12-5 ]

6-Ethoxyquinoline-2-carbaldehyde

Similarity: 0.88

[ 103624-90-4 ]

7-Methoxy-2-methylquinolin-4-ol

Similarity: 0.87

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 6628-28-0 ] {[proInfo.proName]}

Quality Control of [ 6628-28-0 ]

Related Doc. of [ 6628-28-0 ]

Product Details of [ 6628-28-0 ]

Calculated chemistry of [ 6628-28-0 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 6628-28-0 ]

Application In Synthesis of [ 6628-28-0 ]

[ 6628-28-0 ] Synthesis Path-Downstream 1~50

Technical Information

Related Functional Groups of [ 6628-28-0 ]

Ethers

Related Parent Nucleus of [ 6628-28-0 ]

Quinolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 6628-28-0 ]

Related Parent Nucleus of
[ 6628-28-0 ]