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[ CAS No. 66411-17-4 ] {[proInfo.proName]}

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Chemical Structure| 66411-17-4
Chemical Structure| 66411-17-4
Structure of 66411-17-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 66411-17-4 ]

CAS No. :66411-17-4 MDL No. :MFCD09264171
Formula : C9H6Br2O4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 337.95 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 66411-17-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 66411-17-4 ]

[ 66411-17-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4442-53-9 ]
  • [ 66411-17-4 ]
YieldReaction ConditionsOperation in experiment
60% With bromine; acetic acid; at 120℃; for 2h; A 20-mL round bottom flask was charged with 2,3-dihydrobenzo[b][l,4]dioxine- 5-carboxy-lic acid (1.8 g, 1.0 mmol), bromine (3.16 g, 2.0 mmol), and acetic acid (2 mL). The reaction mixture was stirred at 120°C for 2 h and then cooled to 15°C. It was filtered and the solid was washed with acetic acid to afford the title compound as a white solid (3.0 g, 60percent). LCMS: ESI (3 minute run), m/z = 337 [M+l]+; Retention time: 1.21 minute.
With bromine; In acetic acid; 6,7-dibromo-1,4 -benzodioxane-5-carboxylic acid 1,440 ml of acetic acid and 360 g of 1,4-benzodioxane-5-carboxylic acid were introduced into a balloon flask provided with an agitator, an introduction funnel and a condenser. The mixture was heated to 55° C. and then a solution of 700 g of bromine in 360 ml of acetic acid was added in portions. The mixture was heated to 120° C. and then cooled to 15° C. The precipitate was dried off, washed with acetic acid and dried. 332 g of 6,7-dibromo-1,4-benzodioxane-5-carboxylic acid were obtained (M.P.: 212° C.). The structure was confirmed by nuclear magnetic resonance analysis.
  • 2
  • [ 66411-17-4 ]
  • [ 66411-22-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / acetic acid / 1 h / 37 - 50 °C 2: sodium carbonate; palladium on activated charcoal; hydrogen / water / 50 °C / 30003 Torr / Autoclave
Multi-step reaction with 2 steps 1: acetic acid; sulfuric acid; nitric acid / 12 h / 11 - 43 °C / Industrial scale 2: triethylamine; hydrogen; palladium on activated charcoal / methanol; water / 0.5 h / 50 - 75 °C / 3375.34 Torr / Industrial scale
Multi-step reaction with 2 steps 1: acetic acid; sulfuric acid; nitric acid / 2 h / 0 - 25 °C 2: hydrogen; sodium carbonate; palladium 10% on activated carbon / water / 16 h / 50 °C / 7500.75 Torr
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