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CAS No. : | 671802-00-9 | MDL No. : | MFCD22056310 |
Formula : | C9H18O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ACWLDITVZGWIKA-UHFFFAOYSA-N |
M.W : | 190.24 | Pubchem ID : | 11263965 |
Synonyms : |
|
Chemical Name : | tert-Butyl 3-(2-hydroxyethoxy)propanoate |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
24% | With sodium In tetrahydrofuran at 20℃; for 24 h; | To a solution of ethylene glycol 16-1 (13.1 mL, 235 mmol) in 100 mL of tetrahedrofuran was added 47 mg of sodium. 12 mL of tert-butylacrylate was added after sodium was dissolved. The reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was concentrated in vacuo and quenched with 2 mL of 1 N HCl. The residue was suspended in brine and extracted with ethyl acetate (100 mLXl, 50 mL X2). The organic layer was combined and washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash column chromatography to give 5.2 g (24percent) of compound 16-3. |
24% | With sodium In tetrahydrofuran at 20℃; for 24 h; | Compound 16-3: To a solution of ethylene glycol 16-1 (13.1 mL, 235 mmol) in100 rn.L of tetrahedrofuran was added 47 mg of sodium. 12 mL of tert-butylacrylate wasadded after sodimn was dissolved. The reaction rnixtme was stirred at room temperature for5 24 hours. The reaction mixture was concentrated in vacuo and quenched with 2 mL of 1 NHCI. The residue was suspended in brine and extracted with ethyl acetate (100 mLX1, 50 mLX2). The organic layer was combined and washed with brine, dried over sodium sulfate andconcentrated in vacuo. The residue was purified by flash column chromatography to give 5.2g (24percent) of compound 16-3. |
24% | With sodium In tetrahydrofuran at 20℃; for 24 h; | To a solution of ethylene glycol16-1 (13. 1 mL, 235 mmol) in 100 mLoftetrahedrofuran was added 47 mg of sodium. 12 mL oftert-butylacrylate was added after sodiumwas dissolved. The reaction mixture was stirred at room temperature for 24 hours. The reaction5 mixture was concentrated in vacuo and quenched with 2 mL of 1 N HCl. The residue was suspendedin brine and extracted with ethyl acetate (1 00 mLXl, 50 mL X2). The organic layer was combinedand washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue waspurified by flash column chromatography to give 5.2 g (24percent) of compmmd 16-3. |
22% | at 20℃; for 96 h; | tert-Butyl acrylate (5.72 mL, 39.0 mmol) was added to a mixture of ethylene glycol (2.42 g, 39.0 mmol), tetrabutylammonium bromide (377 mg, 1.17 mmol) and potassium hydroxide (77 mg; purity, 85percent; 1.17 mmol), and the mixture was stirred at room temperature for 4 days. The reaction mixture was purified by silica gel column chromatography (hexane:ethyl acetate = 4:1 --> 2: 1, v/v) to give the title compound (1.66 g; yield, 22percent) as a colorless oily substance. 1H NMR (CDCl3, 400 MHz): δ 1.47 (9H, s), 2.44 (1H, brs), 2.52 (2H, t, J = 6.1 Hz), 3.59 (2H, t, J = 5.6 Hz), 3.73-3.76 (4H, m). |
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