Home Cart 0 Sign in  

[ CAS No. 673-22-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 673-22-3
Chemical Structure| 673-22-3
Structure of 673-22-3 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 673-22-3 ]

Related Doc. of [ 673-22-3 ]

Alternatived Products of [ 673-22-3 ]
Product Citations

Product Details of [ 673-22-3 ]

CAS No. :673-22-3 MDL No. :MFCD00003327
Formula : C8H8O3 Boiling Point : -
Linear Structure Formula :(OH)C6H3(CHO)OCH3 InChI Key :WZUODJNEIXSNEU-UHFFFAOYSA-N
M.W : 152.15 Pubchem ID :69600
Synonyms :
4-Methoxysalicylaldehyde;NSC 155334

Calculated chemistry of [ 673-22-3 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.12
Num. rotatable bonds : 2
Num. H-bond acceptors : 3.0
Num. H-bond donors : 1.0
Molar Refractivity : 40.34
TPSA : 46.53 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.61 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.4
Log Po/w (XLOGP3) : 0.87
Log Po/w (WLOGP) : 1.21
Log Po/w (MLOGP) : 0.51
Log Po/w (SILICOS-IT) : 1.49
Consensus Log Po/w : 1.1

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.6
Solubility : 3.8 mg/ml ; 0.0249 mol/l
Class : Very soluble
Log S (Ali) : -1.43
Solubility : 5.64 mg/ml ; 0.0371 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.88
Solubility : 2.0 mg/ml ; 0.0132 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.14

Safety of [ 673-22-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 673-22-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 673-22-3 ]

[ 673-22-3 ] Synthesis Path-Downstream   1~17

  • 1
  • [ 673-22-3 ]
  • [ 57543-36-9 ]
YieldReaction ConditionsOperation in experiment
90% With bromine; acetic acid; at 0 - 20℃; for 2h; In a 250 mL flask, 2-hydroxy-4-methoxybenzaldehyde (5 g, 32.9 mmol) was dissolved in acetic acid (65.7 mL), and cooled to 0 C, then Br2 (1 .862 ml, 36.1 mmol) in 10 mL acetic acid was added slowly. Upon complete addition, the reaction mixture was allowed to warm to room temperature, and stirred for 2 h. 100 mL of water was added to reaction flask, and the resulting white precipitate was filtered and washed with water. Drying under vacuum afforded the title compound (6.8 g, 29.4 mmol, 90 % yield). MS (M+1 ) = 233.3. 1H NMR (400 MHz, CHLOROFORM-d) delta 1 1.45 (s, 1 H), 9.70 (s, 1 H), 7.69 (s, 1 H), 6.49 (s, 1 H), 3.96 (s, 3H).
87% With bromine; acetic acid; at 0 - 20℃; for 1h; To a solution of a commercially available 2-hydroxy-4-methoxybenzaldehyde (1.18 g, 7.76 mmol) in glacial acetic acid (15 mL) was added a solution of Br2 (0.44 mL, 8.62 mmol) in glacial acetic acid (5 mL) at 0 C and the reaction mixture was warmed up and stirred at room temperature for 1 h. Water (30 mL) was added and the precipitate was collected by filtration. Water (30 mL) and CH2Cl2 (30 mL) were added to the white solid and the two phases were separated. The aqueous layer was extracted with CH2Cl2 (3 x 25 mL) and the combined organic layers were washed with brine (30 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure to give the crude product 5-bromo-2-hydroxy-4-methoxybenzaldehyde which was further recrystallized from CH2Cl2 to furnish the desired product as a white solid (1.56 g, 6.75 mmol, 87 %).
80% With bromine; In dichloromethane; at 0 - 20℃; for 3h; 2-HYDROXY-4-METHOXYBENZALDEHYDE (6.0 g, 39 mmol) was dissolved in dichloromethane (50 ML) and cooled to 0 C using an ice-water bath. Bromine (6.8 g, 43 mmol) in dichloromethane (2 mL) was added dropwise to the cooled solution and stirred for 2 h at 0 C. The mixture was warmed to room temperature and stirred for an additional 1 h and the resulting yellow precipitate was collected. Recrystallization (ethyl acetate/hexanes) yielded 7.1 g (80%) of 5-bromo-2-hydroxy-4- methoxybenzaldehyde as white needles, m. p. 63-64'C.'H-NMR (300 MHz, CDC13) 6 11.43 (s, 1 H), 9.69 (s, 1 H), 7.68 (s, 1 H), 6.48 (s, 1 H), 3.95 (s, 3 H). Anal. Calcd. for C8H7BRO3 : C, 41.59 ; H, 3.05. Found: C, 41.86 ; H, 3.05.
76% With tetra-n-butylammonium tribromide; sodium hydrogencarbonate; sodium chloride; In dichloromethane; water; a. 3-Bromo-6-hydroxy-4-methoxy-benzaldehyde. A mixture of 2-hydroxy-4-methoxy-benzaldehyde (3.04 g, 20 mmol) and tetrabutylammonium tribromide (6.40 g, 20 mmol) in anhydrous dichloromethane (200 mL) was stirred at room temperature for 24 hours. The solution was washed successively with a saturated aqueous solution of NaHCO3 (150 mL), water (150 mL), a saturated aqueous solution of NaCl (150 mL), dried over MgSO4 and filtered. Removal of the solvent under reduced pressure gave a solid which was purified by column chromatography, using a Biotage 40M cartridge, eluding with 5% ethyl acetate/95% hexane to give 3-bromo-6-hydroxy-4-methoxy-benzaldehyde as a white solid (3.50 g, 76%). 1H NMR (500 MHz; CDCl3): delta3.94 (s, 3 H), 6.47 (s, 1 H), 7.67 (s, 1 H), 9.68 (s, 1 H), 11.43 (s, 1 H).
76% With tetra-n-butylammonium tribromide; sodium hydrogencarbonate; sodium chloride; In dichloromethane; water; a. 3-Bromo-6-hydroxy-4-methoxy-benzaldehyde A mixture of 2-hydroxy-4-methoxy-benzaldehyde (3.04 g, 20 mmol) and tetrabutylammonium tribromide (6.40 g, 20 mmol) in anhydrous dichloromethane (200 mL) was stirred at room temperature for 24 hours. The solution was washed successively with a saturated aqueous solution of NaHCO3 (150 mL), water (150 mL), a saturated aqueous solution of NaCl (150 mL), dried over MgSO4 and filtered. Removal of the solvent under reduced pressure gave a solid which was purified by column chromatography, using a Biotage 40M cartridge, eluding with 5% ethyl acetate/95% hexane to give 3-bromo-6-hydroxy-4-methoxy-benzaldehyde as a white solid (3.50 g, 76%). 1H NMR (500 MHz; CDCl3): delta3.94 (s, 3H), 6.47 (s, 1H), 7.67 (s, 1H), 9.68 (s, 1H), 11.43 (s, 1H).
With bromine; In dichloromethane; ethyl acetate; Example 62 3-[5-(Benzo[b]thien-2-yl)-2-carboxymethoxy-4-methoxyphenyl]-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one, Sodium Salt Ex-62A: A solution of 2-hydroxy-4-methoxybenzaldehyde (3.03 g, 20 mmol) in 25 mL of dichloromethane was cooled to 0 C. and treated dropwise with a solution of bromine (3.41 g, 21 mmol) in 10 mL of dichloromethane. The reaction mixture was stirred at 0 C. for 1.5 hours. The solvent was removed by rotary evaporation to give a residue. The residue was taken up in EtOAc and washed with 3 portions of water. The organic layer was dried over MgSO4. The drying agent was removed by filtration, and solvent was removed by rotary evaporation to give 3.9 g of the desired 5-bromo-2-hydroxy-4-methoxybenzaldehyde as a solid, m.p. 111-115 C.
With bromine; 2-Hydroxy-4-methoxybenzaldehyde (20 g, 131.4 mmol) was brominated to give 5-bromo-2-hydroxy-4-methoxybenzaldehyde as a light yellow solid, followed by coupling with 4-methoxyphenylboronic acid (750 mg, 4.94 mmol) using method A to give 800 mg (75%) of 4-hydroxy-6,4'-dimethoxybiphenyl-3-carbaldehyde as a light yellow solid.

  • 2
  • [ 673-22-3 ]
  • [ 64175-51-5 ]
  • [ 129354-86-5 ]
  • 3
  • [ 673-22-3 ]
  • [ 64-18-6 ]
  • [ 7726-95-6 ]
  • [ 127-09-3 ]
  • [ 57543-36-9 ]
  • 4
  • [ 673-22-3 ]
  • [ 7726-95-6 ]
  • [ 64-19-7 ]
  • [ 57543-36-9 ]
  • 5
  • [ 673-22-3 ]
  • [ 60-29-7 ]
  • [ 7726-95-6 ]
  • [ 24967-79-1 ]
  • [ 57543-36-9 ]
  • [ 117238-61-6 ]
  • 6
  • [ 673-22-3 ]
  • [ 7726-95-6 ]
  • [ 64-19-7 ]
  • [ 24967-79-1 ]
  • [ 57543-36-9 ]
  • [ 117238-61-6 ]
  • 7
  • [ 673-22-3 ]
  • [ 2632-14-6 ]
  • [ 878196-25-9 ]
  • 8
  • [ 673-22-3 ]
  • [ 5683-31-8 ]
  • 2-formyl-5-methoxyphenyl 3-trimethylsilylpropiolate [ No CAS ]
  • 9
  • [ 673-22-3 ]
  • [ 57543-36-9 ]
  • [ 63638-85-7 ]
  • [ 117238-61-6 ]
  • 10
  • [ 673-22-3 ]
  • [ 1885-13-8 ]
  • 11
  • [ 673-22-3 ]
  • [ 57497-39-9 ]
  • [ 255052-05-2 ]
  • 12
  • [ 673-22-3 ]
  • [ 6964-21-2 ]
  • C14H12O4S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 110℃; General procedure: A solution of ortho-hydroxybenzaldehyde (1-4, 8 mmol), substituted acetic acid (a-c, 10 mmol) and DCC (12 mmol) in dimethylsulfoxide (DMSO, 10 mL), was heated (oil bath) at 110 C for 24-48 h. On completion of the reaction, cold water (100 mL) and acetic acid (15 mL) were added. The reaction mixture was stirred at room temperature for 4 h and extracted with diethyl ether (4 × 100 mL). The precipitated dicyclohexylurea was filtered off. The filtrate was extracted with 5% aqueous NaHCO3 (200 mL). The organic phase was stirred for 1 h with 5% aqueous sodium metabisulfite in order to remove the unreacted hydroxybenzaldehyde. The organic phase was washed with water, dried (Na2SO4) and the solvent removed under reduced pressure. The residue was purified by column chromatography (Hexane/EtOAc, 9:1).
  • 14
  • [ 673-22-3 ]
  • [ 2905-56-8 ]
  • 1-benzyl-3-(2-hydroxy-4-methoxybenzyl)piperidin-2-one [ No CAS ]
  • C20H25NO2 [ No CAS ]
  • C20H23NO2 [ No CAS ]
  • 15
  • [ 673-22-3 ]
  • [ 98-32-8 ]
  • [ 105-56-6 ]
  • 3-(5'-sulfonylamine-2'-benzoxazole)-7-methoxy-2H-1-benzopyran-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% In butan-1-ol; for 7h;Reflux; General procedure: Salicylaldehyde (2 mmol), ethyl cyanoacetate (2 mmol), and o-aminophenol(2 mmol) were mixed in n-BuOH (20 mL), and the solution was refluxed for 7 h.The solvent was removed, and the residue was suspended in EtOH (10 mL) and stirred with 1 percent NaOH (10 mL) for 30 min. After filtration and washing with water,the product was obtained as yellow solid.
  • 16
  • [ 673-22-3 ]
  • [ 7474-78-4 ]
  • 2-(2-hydroxy-4-methoxyphenyl)-1H-benzo[d]imidazole-5-sulfonic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
59% With sodium metabisulfite; In ethanol; water; for 24h;Reflux; General procedure: To a solution of the appropriate 3,4-diaminobenzene derivative (1ad)(2 mmol) in ethanol (15 mL) 2.85 N aqueous solution of sodium metabisulphite (1.6 mL) and the appropriate substituted arylaldehyde(2 mmol) were added. The reaction mixture was heated at reflux for 24 h. The solvent was then evaporated under reduced pressure. The residue was added with HCl 1 N (10 mL), the formed precipitate was filtered off, washed with water (3×10 mL) and purified by crystallization from the adequate solvent to give the title compounds.Following the general procedure benzimidazoles 3 [19], 4 [20], 5 [21],7 [24], 6, 32 and 33 [15] were prepared and their analytical and spectral data are in agreement with those reported in literature.
  • 17
  • [ 673-22-3 ]
  • [ 36997-31-6 ]
  • C33H30N6O9 [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% In methanol; for 24.0h;Reflux; General procedure: The ligands H6L1-7 were prepared by similar methods. A representativemethod for I is presented here. A solution of salicylaldehyde(1.46 g, 12 mmol) in MeOH (30 mL) was added to amethanolic suspension of <strong>[36997-31-6]benzene-1,3,5-tricarbohydrazide</strong>(0.504 g, 2 mmol). The reaction mixture was refluxed on an oilbath. During this period, the <strong>[36997-31-6]benzene-1,3,5-tricarbohydrazide</strong>slowly dissolved and simultaneously a white solid precipitated.After 24 h of reflux, the reaction mixture was cooled at room temperaturefor an hour, the precipitated solid was filtered, washedwith MeOH (2 5 mL) and dried in a desiccator over silica gel.Data for H6L1 (I): Yield 0.954 g (85%). Anal. Calc. for C30H24N6O6(5 6 4): C, 63.83; H, 4.29; N, 14.89. Found: C, 65.31; H, 4.82; N,13.83%. IR data (cm1): 3440 (OAH), 3018 (NAH), 1659 (CO),1563 (CN).
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;