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Chemical Structure| 673477-11-7 Chemical Structure| 673477-11-7

Structure of 673477-11-7

Chemical Structure| 673477-11-7

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Product Details of [ 673477-11-7 ]

CAS No. :673477-11-7
Formula : C9H8BrClN2S
M.W : 291.60
SMILES Code : NC1=NC(C2=CC=CC=C2Cl)=CS1.[H]Br
MDL No. :MFCD00278689

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Application In Synthesis of [ 673477-11-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 673477-11-7 ]

[ 673477-11-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 673477-11-7 ]
  • [ 21344-90-1 ]
YieldReaction ConditionsOperation in experiment
93% With sodium carbonate; In water; ethyl acetate; Thiourea (2.1 g, 27.45 mmol) was added to a solution 2-bromo-l-(2- chlorophenyl)ethanone (7 g, 27.45 mmol) in ethanol (10 mL) and reaction mixture was stirred at RT for 18h. The solvent was evaporated and refluxed for 5 minutes in DCM. Suspension was filtered to yield 7.84 g of 4-(2-chlorophenyl)thiazol-2- amine hydrobromide as a white powder. This powder was stirred in a mixture of aq. sat. Na2CO3 and AcOEt. Phases are separated and organic layer dried overMgSO4, concentrated in vacuo to yield title compound as a yellow oil which solidifies spontaneously. Y: 5.37 g (93percent), P=100percent, rt=2.84 mn (gradient A),(M+H)+ = 211.
 

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